| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Legend of the Guardians: The Owls of Ga'Hoole | $622,557 | - | 160 | - | $3,890 | $622,557 | 1 | Warner Bros. | true | false |
| 2 | 1 | Resident Evil: Afterlife | $224,900 | -44% | 89 | -41 | $2,526 | $2,728,644 | 4 | Sony Pictures Releasing | false | false |
| 3 | - | Eat Pray Love | $133,853 | - | 25 | - | $5,354 | $133,853 | 1 | Sony Pictures Releasing | true | false |
| 4 | 2 | The Last Airbender | $102,910 | -48.9% | 78 | -32 | $1,319 | $3,337,621 | 6 | United International Pictures | false | false |
| 5 | 3 | Wall Street: Money Never Sleeps | $87,949 | -24.6% | 37 | -10 | $2,377 | $248,552 | 2 | 20th Century Fox International | false | false |
| 6 | 4 | Inception | $56,102 | -21.5% | 30 | -5 | $1,870 | $3,041,088 | 9 | Warner Bros. | false | false |
| 7 | 5 | Going the Distance | $37,299 | -40.3% | 27 | -11 | $1,381 | $244,195 | 3 | Warner Bros. | false | false |
| 8 | 6 | Cats & Dogs: The Revenge of Kitty Galore | $24,546 | -37.7% | 34 | -12 | $721 | $2,050,065 | 8 | Warner Bros. | false | false |
| 9 | 10 | From Paris with Love | $20,726 | -3.5% | 21 | -5 | $986 | $100,409 | 3 | - | false | false |
| 10 | 9 | Grown Ups | $15,555 | -29.3% | 14 | -6 | $1,111 | $940,766 | 9 | Sony Pictures Releasing | false | false |
| 11 | - | Despicable Me | $13,357 | - | 33 | - | $404 | $2,754,459 | - | Universal Pictures International (UPI) | - | false |
| 12 | 8 | Vampires Suck | $12,885 | -50.9% | 9 | -12 | $1,431 | $160,802 | 5 | 20th Century Fox International | false | false |
| 13 | 11 | Oceans | $8,713 | -57.2% | 22 | -14 | $396 | $533,940 | 7 | Cine Colombia | false | false |
| 14 | 15 | Green Zone 2010 Re-release | $5,929 | -0.1% | 4 | -6 | $1,482 | $127,147 | 7 | United International Pictures | false | false |
| 15 | - | City of Life and Death | $3,841 | - | 3 | - | $1,280 | $3,841 | 1 | Cineplex | true | false |
| 16 | 13 | The Burning Plain | $3,756 | -67.7% | 4 | -4 | $939 | $51,692 | 3 | Cine Colombia | false | false |
| 17 | 16 | Daybreakers | $3,464 | -11.5% | 5 | -3 | $692 | $113,146 | 5 | Venus | false | false |
| 18 | 12 | The Box | $2,942 | -80.7% | 7 | -16 | $420 | $68,031 | 3 | Cine Colombia | false | false |
| 19 | 14 | Shrek Forever After | $2,268 | -71.8% | 11 | -2 | $206 | $6,838,342 | 13 | United International Pictures | false | false |
| 20 | 17 | Halloween II | $668 | -79.5% | 1 | -6 | $668 | $106,973 | 6 | Cine Colombia | false | false |
