| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Eat Pray Love | $2,076,427 | - | 236 | - | $8,798 | $2,076,427 | 1 | Sony Pictures Releasing | true | false |
| 2 | 1 | Resident Evil: Afterlife | $1,304,249 | -25% | 388 | -29 | $3,361 | $8,021,827 | 3 | Sony Pictures Releasing | false | false |
| 3 | 3 | Grown Ups | $1,204,665 | -5.4% | 178 | +3 | $6,767 | $2,980,374 | 2 | Sony Pictures Releasing | false | false |
| 4 | 2 | Astral City: A Spiritual Journey | $1,105,808 | -28.1% | 397 | -9 | $2,785 | $18,584,707 | 5 | 20th Century Fox International | false | false |
| 5 | - | Vampires Suck | $679,231 | - | 127 | - | $5,348 | $679,231 | 1 | 20th Century Fox International | true | false |
| 6 | 4 | Wall Street: Money Never Sleeps | $549,048 | -29.2% | 156 | +2 | $3,519 | $1,633,783 | 2 | 20th Century Fox International | false | false |
| 7 | 5 | The Last Exorcism | $471,883 | -28.2% | 180 | -2 | $2,621 | $1,424,501 | 2 | PlayArte Pictures | false | false |
| 8 | 6 | The Switch | $247,607 | -37.6% | 67 | -16 | $3,695 | $1,597,846 | 3 | N/A | false | false |
| 9 | 7 | The Karate Kid | $234,443 | -39.6% | 182 | -78 | $1,288 | $9,889,262 | 6 | Sony Pictures Releasing | false | false |
| 10 | 8 | Despicable Me | $111,827 | -31.7% | 194 | - | $576 | $13,424,823 | 9 | Universal Pictures International (UPI) | false | false |
| 11 | 9 | Nanny McPhee Returns | $109,052 | -23% | 47 | -3 | $2,320 | $585,554 | 3 | Universal Pictures International (UPI) | false | false |
| 12 | 11 | The Last Airbender | $69,970 | -37.6% | 101 | -14 | $692 | $9,365,375 | 7 | Paramount Pictures International | false | false |
| 13 | 10 | Going the Distance | $56,468 | -50.5% | 59 | -22 | $957 | $1,512,057 | 4 | Warner Bros. | false | false |
| 14 | 14 | Cats & Dogs: The Revenge of Kitty Galore | $30,327 | -43.9% | 52 | +1 | $583 | $3,549,286 | 5 | Warner Bros. | false | false |
| 15 | 12 | Inception | $28,284 | -71.2% | 30 | -61 | $942 | $10,282,633 | 9 | Warner Bros. | false | false |
| 16 | 17 | The Expendables | $27,934 | -16.9% | 40 | -20 | $698 | $5,638,578 | 8 | N/A | false | false |
| 17 | 15 | The Sorcerer's Apprentice | $24,903 | -34.6% | 57 | -14 | $436 | $4,964,147 | 8 | Walt Disney Pictures | false | false |
| 18 | 13 | Killers | $22,774 | -59.6% | 44 | -27 | $517 | $2,499,722 | 6 | N/A | false | false |
| 19 | 21 | 5x Favela: Now by Ourselves | $21,340 | +12.1% | 29 | +6 | $735 | $747,092 | 6 | Sony Pictures Releasing | false | false |
| 20 | 20 | Solomon Kane | $17,429 | -16.2% | 28 | -2 | $622 | $600,784 | 4 | Paris Filmes | false | false |
| 21 | 16 | Hot Tub Time Machine | $17,110 | -51.8% | 22 | -6 | $777 | $618,449 | 4 | N/A | false | false |
| 22 | 18 | The Well Beloved One | $11,296 | -56.1% | 33 | -21 | $342 | $4,939,308 | 11 | Walt Disney Pictures | false | false |
| 23 | - | Vincere | $9,554 | - | 8 | - | $1,194 | $182,735 | 11 | N/A | false | false |
| 24 | 19 | Baaria | $9,308 | -61.8% | 5 | -5 | $1,861 | $99,935 | 3 | Paris Filmes | false | false |
| 25 | 26 | Toy Story 3 | $8,339 | +153.9% | 60 | +47 | $138 | $24,946,014 | 16 | Walt Disney Pictures | false | false |
| 26 | 24 | Salt | $6,134 | +79.6% | 5 | -5 | $1,226 | $7,379,843 | 10 | Sony Pictures Releasing | false | false |
| 27 | 29 | The Imaginarium of Doctor Parnassus | $297 | -32.5% | 1 | - | $297 | $160,561 | 22 | Sony Pictures Releasing | false | false |
| 28 | 30 | A Prophet | $38 | -53.7% | 3 | +2 | $12 | $161,100 | 16 | Sony Pictures Releasing | false | false |
