| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Wall Street: Money Never Sleeps | $407,186 | - | 89 | - | $4,575 | $424,978 | 1 | Warner Bros. | true | false |
| 2 | 1 | Grown Ups | $292,979 | -18.1% | 62 | +3 | $4,725 | $1,255,512 | 3 | Sony Pictures Releasing | false | false |
| 3 | - | Resident Evil: Afterlife | $279,640 | - | 50 | - | $5,592 | $370,310 | 1 | Entertainment One | true | false |
| 4 | 2 | The American | $229,721 | -19.2% | 35 | +4 | $6,563 | $654,639 | 2 | Benelux Film Distributors | false | false |
| 5 | 3 | Inception | $177,834 | -22% | 96 | -6 | $1,852 | $8,795,788 | 10 | Warner Bros. | false | false |
| 6 | 4 | Devil | $144,530 | -30.5% | 40 | - | $3,613 | $436,466 | 2 | Universal Pictures International (UPI) | false | false |
| 7 | 6 | Going the Distance | $136,387 | -27.9% | 70 | - | $1,948 | $730,636 | 3 | Warner Bros. | false | false |
| 8 | 5 | The Last Airbender | $123,976 | -36.7% | 81 | -2 | $1,530 | $3,510,553 | 6 | Universal Pictures International (UPI) | false | false |
| 9 | 8 | Step Up 3D | $113,743 | -34.3% | 84 | -4 | $1,354 | $4,724,156 | 8 | Independent Films | false | false |
| 10 | 7 | Machete | $110,121 | -37.1% | 51 | - | $2,159 | $733,027 | 3 | Entertainment One | false | false |
| 11 | 9 | Piranha 3D | $81,149 | -40.7% | 47 | -11 | $1,726 | $935,785 | 4 | A-Film Distribution | false | false |
| 12 | 11 | Marmaduke | $79,507 | -27.8% | 82 | - | $969 | $1,582,357 | 7 | Warner Bros. | false | false |
| 13 | 12 | A Turtle's Tale: Sammy's Adventures | $67,958 | -20.7% | 84 | -3 | $809 | $1,744,724 | 8 | Universal Pictures International (UPI) | false | false |
| 14 | 10 | The Expendables | $60,941 | -46.6% | 76 | -11 | $801 | $2,582,408 | 6 | Benelux Film Distributors | false | false |
| 15 | 13 | Toy Story 3 | $59,425 | -26.5% | 109 | - | $545 | $5,956,635 | 14 | Walt Disney Pictures | false | false |
| 16 | 15 | Shrek Forever After | $48,110 | -28.5% | 103 | -6 | $467 | $7,253,108 | 12 | Universal Pictures International (UPI) | false | false |
| 17 | 16 | The Secret in Their Eyes | $40,999 | -22.9% | 14 | - | $2,928 | $423,718 | 5 | Wild Bunch Distribution | false | false |
| 18 | 14 | Salt | $39,425 | -48.4% | 48 | -20 | $821 | $3,041,941 | 8 | Sony Pictures Releasing | false | false |
| 19 | 18 | I Am Love | $37,186 | -23.3% | 16 | - | $2,324 | $426,006 | 5 | Cinéart | false | false |
| 20 | 17 | Cats & Dogs: The Revenge of Kitty Galore | $30,911 | -39.2% | 68 | -2 | $454 | $1,420,441 | 9 | Warner Bros. | false | false |
