| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Resident Evil: Afterlife | $401,886 | -34.5% | 130 | +1 | $3,091 | $2,339,756 | 3 | Sony Pictures Releasing | false | false |
| 2 | 2 | The Last Airbender | $201,581 | -27.1% | 110 | -3 | $1,832 | $3,159,594 | 5 | United International Pictures | false | false |
| 3 | - | Wall Street: Money Never Sleeps | $116,614 | - | 47 | - | $2,481 | $116,614 | 1 | 20th Century Fox International | true | false |
| 4 | 3 | Inception | $71,502 | -17.5% | 35 | -8 | $2,042 | $2,938,477 | 8 | Warner Bros. | false | false |
| 5 | 4 | Going the Distance | $62,491 | -27.2% | 38 | -2 | $1,644 | $182,611 | 2 | Warner Bros. | false | false |
| 6 | 5 | Cats & Dogs: The Revenge of Kitty Galore | $39,386 | -17.6% | 46 | -1 | $856 | $2,001,610 | 7 | Warner Bros. | false | false |
| 7 | - | Despicable Me | $26,489 | - | 50 | - | $529 | $2,713,685 | - | Universal Pictures International (UPI) | - | false |
| 8 | 12 | Vampires Suck | $26,260 | +86.1% | 21 | +3 | $1,250 | $138,048 | 4 | 20th Century Fox International | false | false |
| 9 | 10 | Grown Ups | $22,015 | -10% | 20 | -1 | $1,100 | $918,582 | 8 | Sony Pictures Releasing | false | false |
| 10 | 7 | From Paris with Love | $21,473 | -36.1% | 26 | -2 | $825 | $70,018 | 2 | - | false | false |
| 11 | 6 | Oceans | $20,334 | -46.8% | 36 | -1 | $564 | $515,561 | 6 | Cine Colombia | false | false |
| 12 | 8 | The Box | $15,268 | -51% | 23 | +3 | $663 | $59,431 | 2 | Cine Colombia | false | false |
| 13 | 11 | The Burning Plain | $11,618 | -39% | 8 | -2 | $1,452 | $41,215 | 2 | Cine Colombia | false | false |
| 14 | 13 | Shrek Forever After | $8,033 | -20.8% | 13 | - | $617 | $6,780,761 | 12 | United International Pictures | false | false |
| 15 | 14 | Green Zone 2010 Re-release | $5,936 | -22.6% | 10 | +1 | $593 | $117,188 | 6 | United International Pictures | false | false |
| 16 | 15 | Daybreakers | $3,915 | -48.1% | 8 | -3 | $489 | $106,854 | 4 | Venus | false | false |
| 17 | 16 | Halloween II | $3,258 | -44.7% | 7 | -2 | $465 | $102,708 | 5 | Cine Colombia | false | false |
| 18 | 20 | Cherry Blossoms | $851 | +27.8% | 1 | - | $851 | $123,621 | 12 | Cine Colombia | false | false |
| 19 | 19 | Horn of Plenty 2010 Re-release | $627 | -25.9% | 2 | - | $313 | $26,064 | 4 | Cineplex | false | false |
