| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Resident Evil: Afterlife | $744,050 | - | 98 | - | $7,592 | $744,050 | 1 | Sony Pictures Releasing | true | false |
| 2 | - | Alpha and Omega | $70,803 | - | 45 | - | $1,573 | $70,803 | 1 | N/A | true | false |
| 3 | 2 | Going the Distance | $67,868 | -24.2% | 44 | -1 | $1,542 | $190,848 | 2 | Warner Bros. | false | false |
| 4 | 3 | The American | $39,495 | -43.6% | 20 | - | $1,974 | $142,437 | 2 | N/A | false | false |
| 5 | 4 | Machete | $19,716 | -62.6% | 41 | -9 | $480 | $255,316 | 3 | N/A | false | false |
| 6 | 11 | Inception | $17,446 | -1.3% | 14 | -7 | $1,246 | $1,430,310 | 9 | Warner Bros. | false | false |
| 7 | 6 | The Killer Inside Me | $17,360 | -47.2% | 30 | - | $578 | $60,637 | 2 | N/A | false | false |
| 8 | 5 | Moskva, ya lyublyu tebya! | $16,393 | -58% | 28 | -8 | $585 | $156,905 | 3 | N/A | false | false |
| 9 | - | The Joneses | $12,502 | - | 11 | - | $1,136 | $54,136 | 3 | N/A | false | false |
| 10 | 9 | The Switch | $11,004 | -45.7% | 32 | -8 | $343 | $283,483 | 4 | N/A | false | false |
| 11 | 12 | The Karate Kid | $5,435 | -49% | 35 | -1 | $155 | $310,071 | 5 | Sony Pictures Releasing | false | false |
| 12 | 14 | Cats & Dogs: The Revenge of Kitty Galore | $4,224 | -16.6% | 9 | -10 | $469 | $514,847 | 8 | Warner Bros. | false | false |
| 13 | 15 | Grown Ups | $1,712 | -46.4% | 18 | -2 | $95 | $698,609 | 7 | Sony Pictures Releasing | false | false |
| 14 | 8 | Avatar | $1,224 | -95.5% | 1 | -6 | $1,224 | $8,461,766 | 40 | 20th Century Fox International | false | false |
| 15 | - | Shrek Forever After | $1,134 | - | 1 | - | $1,134 | $4,031,359 | 18 | Paramount Pictures International | false | false |
| 16 | 17 | Despicable Me | $1,086 | -26.2% | 4 | -3 | $271 | $1,099,980 | 10 | Universal Pictures International (UPI) | false | false |
| 17 | 16 | Tinker Bell and the Great Fairy Rescue | $640 | -75.2% | 9 | -12 | $71 | $81,145 | 6 | Walt Disney Pictures | false | false |
| 18 | 18 | Salt | $546 | -56% | 3 | -16 | $182 | $1,242,302 | 8 | Sony Pictures Releasing | false | false |
| 19 | 19 | The Sorcerer's Apprentice | $441 | -22.6% | 3 | -3 | $147 | $1,230,805 | 9 | Walt Disney Pictures | false | false |
| 20 | - | Toy Story 3 | $149 | - | 2 | - | $74 | $667,252 | 13 | Walt Disney Pictures | false | false |
| 21 | 10 | Step Up 3D | $141 | -99.2% | 1 | -17 | $141 | $482,524 | 6 | N/A | false | false |
| 22 | 21 | Predators | $114 | +115.1% | 3 | +2 | $38 | $397,439 | 11 | 20th Century Fox International | false | false |
| 23 | 20 | The Twilight Saga: Eclipse | $106 | -61.6% | 1 | -1 | $106 | $1,686,711 | 11 | N/A | false | false |
