| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Resident Evil: Afterlife | $2,908,641 | - | 425 | - | $6,843 | $2,908,651 | 1 | Sony Pictures Releasing | true | false |
| 2 | 1 | Astral City: A Spiritual Journey | $2,463,160 | -4.9% | 417 | -20 | $5,906 | $13,379,233 | 3 | 20th Century Fox International | false | false |
| 3 | 2 | The Karate Kid | $792,690 | -32.5% | 350 | -25 | $2,264 | $8,834,320 | 4 | Sony Pictures Releasing | false | false |
| 4 | - | The Switch | $578,233 | - | 85 | - | $6,802 | $578,233 | 1 | N/A | true | false |
| 5 | 4 | Going the Distance | $359,782 | -36.7% | 119 | - | $3,023 | $1,123,095 | 2 | Warner Bros. | false | false |
| 6 | - | Nanny McPhee Returns | $233,272 | - | 50 | - | $4,665 | $233,272 | 1 | Universal Pictures International (UPI) | true | false |
| 7 | 6 | Despicable Me | $228,563 | -44.5% | 228 | -62 | $1,002 | $12,592,312 | 7 | Universal Pictures International (UPI) | false | false |
| 8 | 7 | Inception | $216,655 | -46% | 137 | -71 | $1,581 | $9,630,773 | 7 | Warner Bros. | false | false |
| 9 | 3 | Cats & Dogs: The Revenge of Kitty Galore | $192,637 | -73.3% | 114 | -75 | $1,689 | $3,288,263 | 3 | Warner Bros. | false | false |
| 10 | 5 | The Last Airbender | $190,733 | -63.2% | 136 | -62 | $1,402 | $8,748,923 | 5 | Paramount Pictures International | false | false |
| 11 | 8 | Killers | $147,727 | -52.9% | 96 | -20 | $1,538 | $2,249,664 | 4 | N/A | false | false |
| 12 | 10 | Hot Tub Time Machine | $147,574 | -40.1% | 60 | -2 | $2,459 | $479,893 | 2 | N/A | false | false |
| 13 | 11 | The Expendables | $104,381 | -53.2% | 116 | -26 | $899 | $5,316,192 | 6 | N/A | false | false |
| 14 | 9 | Solomon Kane | $104,158 | -58.8% | 65 | -4 | $1,602 | $471,444 | 2 | Paris Filmes | false | false |
| 15 | 12 | The Sorcerer's Apprentice | $82,793 | -46.6% | 117 | -30 | $707 | $4,690,016 | 6 | Walt Disney Pictures | false | false |
| 16 | 13 | 5x Favela: Now by Ourselves | $58,184 | -39.1% | 30 | -4 | $1,939 | $665,254 | 4 | Sony Pictures Releasing | false | false |
| 17 | 14 | The Well Beloved One | $57,399 | +29% | 91 | +1 | $630 | $4,706,570 | 9 | Walt Disney Pictures | false | false |
| 18 | - | Baaria | $40,719 | - | 10 | - | $4,071 | $40,719 | 1 | Paris Filmes | true | false |
| 19 | 15 | [Rec]² | $26,242 | -32.1% | 30 | -7 | $874 | $333,020 | 3 | PlayArte Pictures | false | false |
| 20 | 18 | Then She Found Me | $13,005 | -33.2% | 8 | - | $1,625 | $189,253 | 7 | Europa Filmes | false | false |
| 21 | 22 | Little Nicholas | $12,313 | -18.2% | 11 | +1 | $1,119 | $714,844 | 12 | N/A | false | false |
| 22 | 23 | 400 Against 1: A History of Organized Crime | $10,830 | -18.8% | 40 | -6 | $270 | $597,211 | 7 | PlayArte Pictures | false | false |
| 23 | 17 | Salt | $7,642 | -66.9% | 21 | -36 | $363 | $7,364,896 | 8 | Sony Pictures Releasing | false | false |
| 24 | 24 | Toy Story 3 | $5,066 | -30.1% | 20 | -15 | $253 | $24,130,272 | 14 | Walt Disney Pictures | false | false |
| 25 | 30 | The Last Song | $2,152 | +529.2% | 5 | +2 | $430 | $104,572 | 15 | Walt Disney Pictures | false | false |
| 26 | 16 | Battle for Terra | $2,010 | -93% | 11 | -51 | $182 | $49,480 | 2 | PlayArte Pictures | false | false |
| 27 | 28 | The Back-up Plan | $1,758 | +159.3% | 3 | +2 | $586 | $3,375,187 | 15 | Sony Pictures Releasing | false | false |
| 28 | 32 | The Imaginarium of Doctor Parnassus | $808 | +2,276.5% | 4 | +3 | $202 | $158,460 | 20 | Sony Pictures Releasing | false | false |
| 29 | 25 | A Prophet | $293 | -80.9% | 2 | -4 | $146 | $160,808 | 14 | Sony Pictures Releasing | false | false |
| 30 | 31 | The Two Deaths of Quincas Wateryell | $119 | -63.7% | 5 | -1 | $23 | $1,212,639 | 18 | Walt Disney Pictures | false | false |
