| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Grown Ups | $15,081 | - | 7 | - | $2,154 | $15,081 | 1 | Sony Pictures Releasing | true | false |
| 2 | 2 | The Woman with a Broken Nose | $9,007 | -38.1% | 6 | - | $1,501 | $45,824 | 2 | N/A | false | false |
| 3 | 1 | The Expendables | $8,000 | -46.2% | 5 | - | $1,600 | $91,096 | 3 | N/A | false | false |
| 4 | - | Despicable Me | $6,312 | - | 6 | - | $1,052 | $7,482 | 1 | United International Pictures | true | false |
| 5 | 3 | The Karate Kid | $5,499 | -40.8% | 7 | - | $785 | $21,307 | 2 | Sony Pictures Releasing | false | false |
| 6 | 4 | Inception | $2,288 | -48.7% | 6 | - | $381 | $130,792 | 8 | Warner Bros. | false | false |
| 7 | 8 | Shrek Forever After | $2,000 | -6.1% | 7 | - | $285 | $165,519 | 16 | United International Pictures | false | false |
| 8 | 5 | The Last Airbender | $1,740 | -54.9% | 6 | - | $290 | $43,166 | 4 | United International Pictures | false | false |
| 9 | 6 | Salt | $1,644 | -52.3% | 7 | - | $234 | $69,935 | 6 | Sony Pictures Releasing | false | false |
| 10 | 7 | Letters to Juliet | $1,415 | -49.5% | 4 | +1 | $353 | $17,890 | 4 | N/A | false | false |
| 11 | 11 | Killers | $1,032 | -18.2% | 3 | - | $344 | $70,340 | 10 | N/A | false | false |
| 12 | 9 | Cats & Dogs: The Revenge of Kitty Galore | $949 | -36.6% | 9 | - | $105 | $27,538 | 6 | Warner Bros. | false | false |
| 13 | 13 | Toy Story 3 | $809 | -1.8% | 7 | - | $115 | $69,879 | 13 | Walt Disney Pictures | false | false |
| 14 | 15 | The Twilight Saga: Eclipse | $759 | +21.4% | 5 | - | $151 | $93,581 | 11 | N/A | false | false |
| 15 | 10 | Sex and the City 2 | $582 | -55.7% | 9 | - | $64 | $368,619 | 15 | Warner Bros. | false | false |
| 16 | 14 | The Sorcerer's Apprentice | $582 | -12.9% | 4 | - | $145 | $52,322 | 9 | United International Pictures | false | false |
| 17 | 17 | Prince of Persia: The Sands of Time | $521 | +45.1% | 6 | - | $86 | $154,112 | 15 | Walt Disney Pictures | false | false |
| 18 | 12 | Predators | $484 | -41.5% | 7 | - | $69 | $27,637 | 5 | 20th Century Fox International | false | false |
| 19 | 18 | Knight and Day 2010 Re-release | $347 | +23% | 7 | - | $49 | $35,270 | 7 | 20th Century Fox International | false | false |
| 20 | 16 | A Nightmare on Elm Street | $347 | -41% | 6 | - | $57 | $60,432 | 13 | Warner Bros. | false | false |
| 21 | 19 | When You're Strange | $297 | +9.2% | 1 | - | $297 | $9,354 | 7 | N/A | false | false |
| 22 | 21 | Get Him to the Greek | $56 | +7.7% | 4 | - | $14 | $14,548 | 8 | United International Pictures | false | false |
