| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Grown Ups | $343,936 | - | 53 | - | $6,489 | $359,781 | 1 | Sony Pictures Releasing | true | false |
| 2 | 1 | The Last Airbender | $243,200 | -29.1% | 86 | -1 | $2,827 | $2,900,892 | 4 | Universal Pictures International (UPI) | false | false |
| 3 | 2 | Inception | $234,587 | -16.4% | 102 | -2 | $2,299 | $7,732,930 | 8 | Warner Bros. | false | false |
| 4 | - | Machete | $234,089 | - | 51 | - | $4,589 | $262,028 | 1 | Entertainment One | true | false |
| 5 | - | Going the Distance | $198,961 | - | 70 | - | $2,842 | $244,962 | 1 | Warner Bros. | true | false |
| 6 | 5 | Step Up 3D | $198,235 | -15.9% | 91 | - | $2,178 | $4,078,633 | 6 | Independent Films | false | false |
| 7 | 3 | Piranha 3D | $189,715 | -31.4% | 55 | -1 | $3,449 | $574,693 | 2 | A-Film Distribution | false | false |
| 8 | 4 | The Expendables | $154,591 | -40.5% | 92 | +1 | $1,680 | $2,179,357 | 4 | Benelux Film Distributors | false | false |
| 9 | 9 | Marmaduke | $91,683 | +32.3% | 83 | +2 | $1,104 | $1,241,518 | 5 | Warner Bros. | false | false |
| 10 | 7 | Salt | $91,013 | -36.7% | 75 | -3 | $1,213 | $2,701,841 | 6 | Sony Pictures Releasing | false | false |
| 11 | 6 | Dinner for Schmucks | $77,520 | -51.7% | 49 | - | $1,582 | $683,415 | 3 | Universal Pictures International (UPI) | false | false |
| 12 | 14 | A Turtle's Tale: Sammy's Adventures | $74,065 | +36.5% | 88 | -2 | $841 | $1,443,748 | 6 | Universal Pictures International (UPI) | false | false |
| 13 | 13 | Toy Story 3 | $72,100 | +28.8% | 109 | -6 | $661 | $5,430,056 | 12 | Walt Disney Pictures | false | false |
| 14 | 11 | Shrek Forever After | $64,361 | +7.4% | 116 | -11 | $554 | $6,676,058 | 10 | Universal Pictures International (UPI) | false | false |
| 15 | 10 | The Secret in Their Eyes | $60,370 | -0.6% | 14 | +1 | $4,312 | $267,608 | 3 | Wild Bunch Distribution | false | false |
| 16 | 12 | I Am Love | $53,392 | -10% | 16 | - | $3,337 | $277,333 | 3 | Cinéart | false | false |
| 17 | 17 | Cats & Dogs: The Revenge of Kitty Galore | $39,101 | +35.2% | 74 | -6 | $528 | $1,228,890 | 7 | Warner Bros. | false | false |
| 18 | 8 | Vampires Suck | $32,684 | -57% | 45 | -3 | $726 | $342,896 | 3 | Warner Bros. | false | false |
| 19 | 15 | The Karate Kid | $26,265 | -27.6% | 62 | -13 | $423 | $3,667,752 | 8 | Sony Pictures Releasing | false | false |
| 20 | 16 | Knight and Day 2010 Re-release | $19,400 | -44.5% | 31 | -19 | $625 | $3,130,158 | 9 | Warner Bros. | false | false |
