| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Last Exorcism | $1,707,818 | - | 313 | - | $5,456 | $1,707,818 | 1 | Optimum Releasing | true | false |
| 2 | - | Dinner for Schmucks | $1,453,900 | - | 428 | - | $3,396 | $1,453,900 | 1 | Paramount Pictures International | true | false |
| 3 | 3 | Toy Story 3 | $1,444,374 | -38% | 497 | -29 | $2,906 | $108,013,689 | 7 | Walt Disney Pictures | false | false |
| 4 | 1 | Grown Ups | $1,357,376 | -56.5% | 396 | -5 | $3,427 | $6,482,842 | 2 | Sony Pictures Releasing | false | false |
| 5 | 2 | Scott Pilgrim vs. the World | $1,085,946 | -56.4% | 414 | +6 | $2,623 | $5,243,598 | 2 | Universal Pictures International (UPI) | false | false |
| 6 | - | The Switch | $1,029,490 | - | 357 | - | $2,883 | $1,029,490 | 1 | Lionsgate | true | false |
| 7 | 4 | The Expendables | $970,377 | -52.4% | 404 | -49 | $2,401 | $13,057,900 | 3 | Lionsgate | false | false |
| 8 | 5 | Salt | $787,274 | -47.6% | 364 | -49 | $2,162 | $8,762,143 | 3 | Sony Pictures Releasing | false | false |
| 9 | 6 | Piranha 3D | $690,783 | -49.8% | 292 | -43 | $2,365 | $6,903,929 | 3 | Entertainment Film Distributors | false | false |
| 10 | 7 | Inception | $645,040 | -40.6% | 258 | -81 | $2,500 | $52,640,667 | 8 | Warner Bros. | false | false |
| 11 | 10 | Marmaduke | $562,800 | -38.2% | 428 | -29 | $1,314 | $6,615,652 | 3 | 20th Century Fox International | false | false |
| 12 | 8 | Diary of a Wimpy Kid | $474,590 | -54.5% | 365 | -7 | $1,300 | $2,244,462 | 2 | 20th Century Fox International | false | false |
| 13 | 9 | Avatar | $423,756 | -56.3% | 296 | -47 | $1,431 | $144,437,854 | 38 | 20th Century Fox International | false | false |
| 14 | 12 | The Girl Who Played with Fire | $334,609 | -46.8% | 141 | +15 | $2,373 | $1,399,495 | 2 | Momentum Pictures | false | false |
| 15 | - | We Are Family | $251,744 | - | 51 | - | $4,936 | $251,744 | 1 | UTV Motion Pictures | true | false |
