| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Resident Evil: Afterlife | $791,248 | - | 125 | - | $6,329 | $791,248 | 1 | Sony Pictures Releasing | true | false |
| 2 | 1 | The Last Airbender | $342,426 | -52.8% | 113 | -65 | $3,030 | $2,522,804 | 3 | United International Pictures | false | false |
| 3 | 2 | Inception | $125,870 | -42.5% | 78 | -20 | $1,613 | $2,704,449 | 6 | Warner Bros. | false | false |
| 4 | 5 | Oceans | $51,431 | -32.5% | 33 | -3 | $1,558 | $429,191 | 4 | Cine Colombia | false | false |
| 5 | 4 | Grown Ups | $48,571 | -47.8% | 37 | -12 | $1,312 | $849,210 | 6 | Sony Pictures Releasing | false | false |
| 6 | - | Despicable Me | $25,165 | - | 55 | - | $457 | $2,648,853 | - | Universal Pictures International (UPI) | - | false |
| 7 | 8 | Vampires Suck | $22,034 | -57.7% | 21 | +1 | $1,049 | $88,239 | 2 | 20th Century Fox International | false | false |
| 8 | 12 | Halloween II | $13,868 | -3.7% | 19 | -1 | $729 | $84,321 | 3 | Cine Colombia | false | false |
| 9 | 7 | Daybreakers | $11,741 | -78.6% | 32 | -1 | $366 | $86,752 | 2 | Venus | false | false |
| 10 | 11 | Shrek Forever After | $9,875 | -34.8% | 17 | -12 | $580 | $6,757,415 | 10 | United International Pictures | false | false |
| 11 | 9 | Predators | $7,387 | -71.1% | 18 | -11 | $410 | $510,550 | 5 | 20th Century Fox International | false | false |
| 12 | 3 | Cats & Dogs: The Revenge of Kitty Galore | $5,037 | -96% | 60 | -35 | $83 | $1,889,241 | 5 | Warner Bros. | false | false |
| 13 | 14 | Horn of Plenty 2010 Re-release | $4,815 | -59.7% | 5 | -11 | $963 | $21,909 | 2 | Cineplex | false | false |
| 14 | 13 | Green Zone 2010 Re-release | $2,597 | -81.9% | 9 | -10 | $288 | $98,999 | 4 | United International Pictures | false | false |
| 15 | 15 | Cherry Blossoms | $2,556 | -38.4% | 5 | +1 | $511 | $119,986 | 10 | Cine Colombia | false | false |
| 16 | 10 | The Sorcerer's Apprentice | $2,040 | -89.9% | 8 | -16 | $255 | $2,950,828 | 9 | Walt Disney Pictures | false | false |
| 17 | 19 | Salt | $663 | -36.9% | 1 | -2 | $663 | $823,455 | 8 | Sony Pictures Releasing | false | false |
| 18 | 18 | Cloud 9 2009 Re-release | $543 | -56.7% | 1 | -1 | $543 | $52,628 | 7 | Cine Colombia | false | false |
