| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Expendables | $6,115,229 | - | 453 | - | $13,499 | $6,115,229 | 1 | Lionsgate | true | false |
| 2 | - | Salt | $3,366,608 | - | 346 | - | $9,730 | $3,366,608 | 1 | Sony Pictures Releasing | true | false |
| 3 | 1 | Toy Story 3 | $3,275,090 | -33.6% | 557 | -12 | $5,879 | $99,206,661 | 5 | Walt Disney Pictures | false | false |
| 4 | - | Piranha 3D | $2,059,268 | - | 354 | - | $5,817 | $2,059,268 | 1 | Entertainment Film Distributors | true | false |
| 5 | - | Marmaduke | $1,932,580 | - | 377 | - | $5,126 | $1,932,580 | 1 | 20th Century Fox International | true | false |
| 6 | 2 | Inception | $1,672,037 | -36.2% | 419 | -53 | $3,990 | $49,061,277 | 6 | Warner Bros. | false | false |
| 7 | 4 | Knight and Day 2010 Re-release | $1,282,947 | -46.2% | 432 | -9 | $2,969 | $12,357,305 | 3 | 20th Century Fox International | false | false |
| 8 | 3 | The Last Airbender | $919,199 | -64.4% | 440 | -10 | $2,089 | $5,150,201 | 2 | Paramount Pictures International | false | false |
| 9 | 6 | Step Up 3D | $794,552 | -52.7% | 350 | -51 | $2,270 | $10,316,476 | 3 | Universal Pictures International (UPI) | false | false |
| 10 | 5 | The Sorcerer's Apprentice | $690,054 | -61.2% | 393 | -13 | $1,755 | $3,689,865 | 2 | Walt Disney Pictures | false | false |
| 11 | 7 | The Karate Kid | $593,974 | -50.2% | 369 | -59 | $1,609 | $18,044,476 | 4 | Sony Pictures Releasing | false | false |
| 12 | 8 | The A-Team | $518,263 | -56.4% | 336 | -77 | $1,542 | $15,281,498 | 4 | 20th Century Fox International | false | false |
| 13 | 9 | Cats & Dogs: The Revenge of Kitty Galore | $302,601 | -60.3% | 363 | -117 | $833 | $6,171,863 | 3 | Warner Bros. | false | false |
| 14 | 10 | Tinker Bell and the Great Fairy Rescue | $284,231 | -36.8% | 235 | -1 | $1,209 | $1,164,811 | 2 | Walt Disney Pictures | false | false |
| 15 | - | The Illusionist | $256,297 | - | 42 | - | $6,102 | $256,297 | 1 | Warner Bros. | true | false |
