| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Step Up 3D | $584,500 | - | 73 | - | $8,006 | $584,500 | 1 | NuMetro Distribution | true | false |
| 2 | 1 | Grown Ups | $174,694 | -41.3% | 65 | - | $2,687 | $649,643 | 2 | Sony Pictures Releasing | false | false |
| 3 | 3 | Inception | $145,843 | -33.4% | 61 | - | $2,390 | $879,269 | 3 | Warner Bros. | false | false |
| 4 | 2 | Shrek Forever After | $105,051 | -64.2% | 77 | -17 | $1,364 | $2,924,217 | 5 | United International Pictures | false | false |
| 5 | 4 | Cats & Dogs: The Revenge of Kitty Galore | $89,853 | -50.1% | 71 | - | $1,265 | $378,780 | 2 | Warner Bros. | false | false |
| 6 | 5 | Knight and Day 2010 Re-release | $88,416 | -44.4% | 70 | -1 | $1,263 | $1,131,860 | 4 | 20th Century Fox International | false | false |
| 7 | 8 | Mao's Last Dancer | $37,167 | -18.5% | 15 | - | $2,477 | $116,073 | 2 | NuMetro Distribution | false | false |
| 8 | 7 | Predators | $31,844 | -52.1% | 40 | - | $796 | $138,996 | 2 | 20th Century Fox International | false | false |
| 9 | 9 | Death at a Funeral | $14,351 | -51.6% | 20 | -6 | $717 | $1,040,325 | 9 | Sony Pictures Releasing | false | false |
| 10 | 10 | Toy Story 3 | $11,193 | -60% | 21 | -15 | $533 | $3,266,853 | 8 | Walt Disney Pictures | false | false |
| 11 | - | Please Give | $9,714 | - | 7 | - | $1,387 | $9,714 | 1 | Sony Pictures Releasing | true | false |
| 12 | 13 | She's Out of My League | $8,148 | -47.3% | 24 | +1 | $339 | $646,388 | 8 | United International Pictures | false | false |
| 13 | 12 | Schuks Tshabalala's Survival Guide to South Africa | $6,286 | -66.5% | 17 | -12 | $369 | $5,144,445 | 12 | N/A | false | false |
| 14 | 14 | The White Ribbon | $5,372 | -54.4% | 6 | -1 | $895 | $30,989 | 3 | United International Pictures | false | false |
| 15 | 15 | The Boys Are Back | $3,861 | -52.5% | 6 | -2 | $643 | $99,457 | 6 | N/A | false | false |
| 16 | - | Shirley Adams | $3,153 | - | 10 | - | $315 | $3,153 | 1 | N/A | true | false |
| 17 | 16 | Broken Embraces | $1,768 | -58.5% | 3 | -2 | $589 | $82,062 | 9 | Ster-Kinekor Pictures | false | false |
| 18 | 21 | Themba | $764 | -31.7% | 3 | -1 | $254 | $19,192 | 5 | N/A | false | false |
| 19 | 18 | Antichrist | $577 | -68.4% | 1 | -1 | $577 | $6,204 | 3 | United International Pictures | false | false |
| 20 | 22 | Green Zone 2010 Re-release | $516 | -45.2% | 4 | +3 | $129 | $289,702 | 12 | United International Pictures | false | false |
| 21 | 20 | I Love You Phillip Morris | $201 | -83.1% | 2 | -2 | $100 | $153,086 | 6 | United International Pictures | false | false |
