| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Toy Story 3 | $7,440,989 | -41.6% | 555 | -9 | $13,407 | $82,167,093 | 3 | Walt Disney Pictures | false | false |
| 2 | - | Knight and Day 2010 Re-release | $3,833,963 | - | 434 | - | $8,834 | $3,833,963 | 1 | 20th Century Fox International | true | false |
| 3 | 4 | Inception | $3,603,417 | -28.9% | 468 | +9 | $7,699 | $41,015,587 | 4 | Warner Bros. | false | false |
| 4 | - | Step Up 3D | $3,214,000 | - | 400 | - | $8,035 | $3,214,000 | 1 | Universal Pictures International (UPI) | true | false |
| 5 | - | Cats & Dogs: The Revenge of Kitty Galore | $2,476,605 | - | 408 | - | $6,070 | $2,476,605 | 1 | Warner Bros. | true | false |
| 6 | 2 | The Karate Kid | $2,250,923 | -70.6% | 446 | - | $5,046 | $13,660,483 | 2 | Sony Pictures Releasing | false | false |
| 7 | 3 | The A-Team | $2,211,664 | -60.5% | 453 | +2 | $4,882 | $11,229,434 | 2 | 20th Century Fox International | false | false |
| 8 | 5 | Shrek Forever After | $578,028 | -59.1% | 407 | -83 | $1,420 | $48,587,938 | 6 | Paramount Pictures International | false | false |
| 9 | 6 | The Twilight Saga: Eclipse | $517,437 | -57.7% | 271 | -138 | $1,909 | $46,040,614 | 5 | Entertainment One | false | false |
| 10 | 8 | Gainsbourg: A Heroic Life | $138,940 | -34.4% | 50 | -9 | $2,778 | $547,733 | 2 | Optimum Releasing | false | false |
| 11 | - | Coco Chanel & Igor Stravinsky | $84,319 | - | 36 | - | $2,342 | $84,319 | 1 | Soda Pictures | true | false |
| 12 | - | Aisha | $84,136 | - | 25 | - | $3,365 | $84,136 | 1 | N/A | true | false |
| 13 | 14 | Tooth Fairy | $51,375 | +18.7% | 98 | -31 | $524 | $6,165,210 | 26 | 20th Century Fox International | false | false |
| 14 | 7 | The Rebound | $46,108 | -83.6% | 52 | -195 | $886 | $1,792,015 | 31 | Momentum Pictures | false | false |
| 15 | 9 | Predators | $36,884 | -79% | 47 | -117 | $784 | $9,198,102 | 5 | 20th Century Fox International | false | false |
