| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Despicable Me | $2,591,249 | -12% | 387 | +7 | $6,695 | $6,860,892 | 2 | Universal Pictures International (UPI) | false | false |
| 2 | 2 | Inception | $1,579,641 | -21.3% | 292 | -22 | $5,409 | $4,479,982 | 2 | Warner Bros. | false | false |
| 3 | - | The Sorcerer's Apprentice | $1,414,407 | - | 217 | - | $6,518 | $1,414,407 | 1 | Walt Disney Pictures | true | false |
| 4 | - | The Expendables | $1,290,442 | - | 179 | - | $7,209 | $1,290,442 | 1 | N/A | true | false |
| 5 | 3 | Salt | $841,921 | -40.3% | 250 | - | $3,367 | $6,091,370 | 3 | Sony Pictures Releasing | false | false |
| 6 | 4 | Shrek Forever After | $515,037 | -52.3% | 369 | -68 | $1,395 | $39,194,945 | 6 | Paramount Pictures International | false | false |
| 7 | 5 | The Well Beloved One | $334,991 | -31.5% | 140 | -14 | $2,392 | $3,681,255 | 4 | Walt Disney Pictures | false | false |
| 8 | 7 | The Twilight Saga: Eclipse | $117,568 | -67.7% | 169 | -131 | $695 | $30,403,911 | 7 | Paris Filmes | false | false |
| 9 | 6 | Knight and Day 2010 Re-release | $104,283 | -71.8% | 160 | -106 | $651 | $8,539,760 | 5 | 20th Century Fox International | false | false |
| 10 | 8 | 400 Against 1: A History of Organized Crime | $80,236 | -51.8% | 76 | - | $1,055 | $337,788 | 2 | PlayArte Pictures | false | false |
| 11 | - | Mother and Child | $58,548 | - | 20 | - | $2,927 | $58,548 | 1 | PlayArte Pictures | true | false |
| 12 | 9 | Toy Story 3 | $54,720 | -65.8% | 133 | -74 | $411 | $23,929,945 | 9 | Walt Disney Pictures | false | false |
| 13 | 10 | Predators | $31,970 | -59.7% | 75 | -24 | $426 | $1,949,071 | 4 | 20th Century Fox International | false | false |
| 14 | 11 | Little Nicholas | $31,425 | -6% | 18 | - | $1,745 | $565,295 | 7 | N/A | false | false |
| 15 | 12 | Then She Found Me | $18,949 | -7.5% | 11 | -1 | $1,722 | $48,009 | 2 | Europa Filmes | false | false |
| 16 | 17 | Death Proof 2010 Re-release | $12,168 | +20.4% | 26 | +16 | $468 | $426,110 | 5 | PlayArte Pictures | false | false |
| 17 | 15 | Whatever Works | $9,376 | -27.4% | 9 | -3 | $1,041 | $1,580,164 | 16 | N/A | false | false |
| 18 | 19 | Bright Star | $7,912 | -17.6% | 20 | +4 | $395 | $385,261 | 8 | PlayArte Pictures | false | false |
| 19 | 16 | Ponyo | $7,801 | -26.2% | 26 | -4 | $300 | $126,580 | 3 | PlayArte Pictures | false | false |
| 20 | 14 | Prince of Persia: The Sands of Time | $7,459 | -50.7% | 24 | - | $310 | $10,075,439 | 11 | Walt Disney Pictures | false | false |
| 21 | 18 | The Back-up Plan | $6,961 | -28.2% | 27 | -5 | $257 | $3,356,234 | 10 | Sony Pictures Releasing | false | false |
| 22 | 13 | Letters to Juliet | $6,913 | -55.6% | 10 | -3 | $691 | $1,861,051 | 10 | Paris Filmes | false | false |
| 23 | 21 | The Secret in Their Eyes | $4,219 | -7.3% | 8 | -3 | $527 | $1,805,523 | 25 | Europa Filmes | false | false |
| 24 | 22 | A Prophet | $3,276 | +20.8% | 4 | - | $819 | $146,680 | 9 | Sony Pictures Releasing | false | false |
| 25 | 20 | The Young Victoria | $2,873 | -57.8% | 8 | -5 | $359 | $511,100 | 9 | Europa Filmes | false | false |
| 26 | 24 | I Love You Phillip Morris | $1,846 | -25.6% | 6 | - | $307 | $1,060,196 | 11 | N/A | false | false |
| 27 | 27 | The Two Deaths of Quincas Wateryell | $1,579 | +133.6% | 11 | +3 | $143 | $1,183,837 | 13 | Walt Disney Pictures | false | false |
| 28 | 26 | The Imaginarium of Doctor Parnassus | $739 | -60.3% | 3 | -1 | $246 | $150,610 | 15 | Sony Pictures Releasing | false | false |
| 29 | - | The Best Things in the World | $474 | - | 1 | - | $474 | $1,198,120 | 18 | Warner Bros. | false | false |
| 30 | 25 | Dear John | $322 | -86.4% | 1 | -4 | $322 | $252,254 | 15 | Sony Pictures Releasing | false | false |
| 31 | - | Chico Xavier | $313 | - | 2 | - | $156 | $17,226,503 | 20 | Sony Pictures Releasing | false | false |
| 32 | 30 | Alice in Wonderland | $67 | -47.7% | 1 | -1 | $67 | $27,330,649 | 17 | Walt Disney Pictures | false | false |
| 33 | 28 | The Last Song | $62 | -67.2% | 1 | -1 | $62 | $100,073 | 10 | Walt Disney Pictures | false | false |
