| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Inception | $2,820,493 | -26.3% | 422 | +4 | $6,683 | $24,323,688 | 4 | Warner Bros. | false | false |
| 2 | - | The Expendables | $2,806,464 | - | 224 | - | $12,528 | $2,806,464 | 1 | Roadshow Films | true | false |
| 3 | 2 | Step Up 3D | $1,885,956 | -35.4% | 314 | -2 | $6,006 | $5,872,440 | 2 | Universal Pictures International (UPI) | false | false |
| 4 | - | Scott Pilgrim vs. the World | $842,691 | - | 178 | - | $4,734 | $890,029 | 1 | Universal Pictures International (UPI) | true | false |
| 5 | 3 | Killers | $579,865 | -44.1% | 246 | -7 | $2,357 | $4,394,350 | 3 | Roadshow Films | false | false |
| 6 | - | The Ghost Writer | $531,591 | - | 76 | - | $6,994 | $710,090 | 1 | Hoyts Distribution | true | false |
| 7 | - | Toy Story 3 | $324,134 | - | 176 | - | $1,841 | $37,259,683 | - | Walt Disney Pictures | - | false |
| 8 | 4 | Knight and Day 2010 Re-release | $277,313 | -51.1% | 166 | -90 | $1,670 | $8,773,340 | 5 | 20th Century Fox International | false | false |
| 9 | 6 | The Twilight Saga: Eclipse | $191,415 | -52.5% | 152 | -75 | $1,259 | $28,357,326 | 7 | - | false | false |
| 10 | 7 | The Karate Kid | $145,481 | -51.9% | 163 | -41 | $892 | $11,819,438 | 6 | Sony Pictures Releasing | false | false |
| 11 | 8 | The Special Relationship | $109,650 | -29.5% | 52 | - | $2,108 | $372,476 | 2 | Roadshow Films | false | false |
| 12 | 12 | Me and Orson Welles | $67,136 | -23.9% | 28 | +2 | $2,397 | $334,759 | 3 | Madman Entertainment | false | false |
| 13 | 21 | Hubble | $64,911 | +4,596.9% | 5 | +4 | $12,982 | $93,413 | 14 | IMAX | false | false |
| 14 | 15 | South Solitary | $62,578 | -23.5% | 44 | +9 | $1,422 | $358,751 | 3 | Icon Film Distribution Australia | false | false |
| 15 | - | Splice 2010 Re-release | $53,817 | - | 38 | - | $1,416 | $53,817 | 1 | Madman Entertainment | true | false |
| 16 | 10 | Grown Ups | $52,555 | -58.5% | 64 | -52 | $821 | $10,684,696 | 8 | Sony Pictures Releasing | false | false |
| 17 | - | Peepli Live | $42,824 | - | 7 | - | $6,117 | $42,824 | 1 | Mind Blowing Films | true | false |
| 18 | 13 | Shrek Forever After | $37,418 | -55% | 46 | -48 | $813 | $24,485,148 | 9 | Paramount Pictures International | false | false |
| 19 | 16 | I Am Love | $35,825 | -35.6% | 25 | -5 | $1,433 | $1,265,473 | 8 | Rialto Distribution | false | false |
| 20 | 11 | Predators | $34,379 | -69.1% | 48 | -53 | $716 | $5,573,925 | 6 | 20th Century Fox International | false | false |
| 21 | - | Everlasting Moments 2010 Re-release | $17,847 | - | 11 | - | $1,622 | $17,847 | 1 | Icon Film Distribution Australia | true | false |
| 22 | - | Four Lions | $9,502 | - | 11 | - | $863 | $9,502 | - | Hopscotch Films | - | false |
| 23 | - | The First Day of the Rest of Your Life | $5,543 | - | 3 | - | $1,847 | $5,543 | 1 | Rialto Distribution | true | false |
| 24 | - | The Nothing Men | $4,036 | - | 3 | - | $1,345 | $4,036 | 1 | N/A | true | false |
| 25 | - | At World's End | $715 | - | 2 | - | $357 | $715 | 1 | N/A | true | false |
