| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Grown Ups | $249,306 | - | 50 | - | $4,986 | $249,306 | 1 | Sony Pictures Releasing | true | false |
| 2 | 1 | Salt | $210,757 | -61.4% | 78 | -1 | $2,702 | $943,087 | 2 | Sony Pictures Releasing | false | false |
| 3 | 2 | Inception | $138,352 | -33.4% | 52 | - | $2,660 | $947,310 | 3 | Warner Bros. | false | false |
| 4 | 4 | Cats & Dogs: The Revenge of Kitty Galore | $98,499 | -33% | 55 | +2 | $1,790 | $310,285 | 2 | Warner Bros. | false | false |
| 5 | 3 | The Sorcerer's Apprentice | $85,551 | -55.1% | 86 | - | $994 | $1,067,962 | 3 | Walt Disney Pictures | false | false |
| 6 | 5 | Despicable Me | $52,507 | -30.5% | 72 | - | $729 | $988,011 | 4 | Universal Pictures International (UPI) | false | false |
| 7 | 6 | The Last Airbender | $29,917 | -21% | 70 | -1 | $427 | $1,689,066 | 5 | Paramount Pictures International | false | false |
| 8 | - | The Twilight Saga: Eclipse | $12,310 | - | 53 | - | $232 | $1,643,139 | 5 | N/A | false | false |
| 9 | 7 | Predators | $8,214 | -29.1% | 32 | -3 | $256 | $375,379 | 5 | 20th Century Fox International | false | false |
| 10 | 13 | Shrek Forever After | $2,725 | +1,422.3% | 2 | - | $1,362 | $3,962,521 | 12 | Paramount Pictures International | false | false |
| 11 | 10 | Avatar | $1,642 | +365.2% | 3 | +1 | $547 | $8,294,586 | 34 | 20th Century Fox International | false | false |
| 12 | 9 | Knight and Day 2010 Re-release | $1,451 | +26.5% | 4 | - | $362 | $602,090 | 7 | 20th Century Fox International | false | false |
| 13 | 8 | Toy Story 3 | $1,062 | -46.7% | 5 | -17 | $212 | $664,731 | 7 | Walt Disney Pictures | false | false |
| 14 | 11 | The Alien Girl | $523 | +80.3% | 3 | -1 | $174 | $116,606 | 6 | N/A | false | false |
| 15 | 12 | Get Him to the Greek | $311 | +54% | 2 | - | $155 | $158,781 | 8 | Universal Pictures International (UPI) | false | false |
| 16 | 17 | Prince of Persia: The Sands of Time | $299 | +896.7% | 1 | - | $299 | $1,580,453 | 10 | Walt Disney Pictures | false | false |
| 17 | 16 | Cop Out | $117 | +42.7% | 2 | - | $58 | $158,656 | 8 | Warner Bros. | false | false |
