| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Shrek Forever After | $662,383 | -19.3% | 105 | - | $6,308 | $1,699,785 | 2 | United International Pictures | false | false |
| 2 | - | Knight and Day 2010 Re-release | $368,361 | - | 70 | - | $5,262 | $368,361 | 1 | 20th Century Fox International | true | false |
| 3 | 2 | The Twilight Saga: Eclipse | $168,480 | -34.7% | 87 | -1 | $1,936 | $3,368,242 | 4 | NuMetro Distribution | false | false |
| 4 | 3 | Schuks Tshabalala's Survival Guide to South Africa | $102,742 | -32.4% | 87 | -5 | $1,180 | $4,906,561 | 9 | N/A | false | false |
| 5 | 4 | Toy Story 3 | $97,860 | -9.8% | 67 | -7 | $1,460 | $3,042,482 | 5 | Walt Disney Pictures | false | false |
| 6 | 5 | Death at a Funeral | $53,316 | -11.1% | 34 | -5 | $1,568 | $885,710 | 6 | Sony Pictures Releasing | false | false |
| 7 | 6 | A Nightmare on Elm Street | $44,127 | -21.7% | 25 | - | $1,765 | $120,620 | 2 | NuMetro Distribution | false | false |
| 8 | 8 | She's Out of My League | $29,783 | -6.9% | 34 | +7 | $875 | $538,737 | 5 | United International Pictures | false | false |
| 9 | 7 | Killers | $24,051 | -31.5% | 29 | -6 | $829 | $1,038,093 | 8 | NuMetro Distribution | false | false |
| 10 | 12 | The Boys Are Back | $12,466 | -18.1% | 10 | - | $1,246 | $64,522 | 3 | N/A | false | false |
| 11 | 9 | I Love You Phillip Morris | $12,337 | -60.6% | 23 | -20 | $536 | $141,329 | 3 | United International Pictures | false | false |
| 12 | 11 | Prince of Persia: The Sands of Time | $11,676 | -36.8% | 16 | -8 | $729 | $1,761,656 | 10 | Walt Disney Pictures | false | false |
| 13 | 13 | Letters to Juliet | $9,271 | -21.2% | 12 | -2 | $772 | $457,646 | 7 | NuMetro Distribution | false | false |
| 14 | 10 | Marmaduke | $7,193 | -61.5% | 17 | -32 | $423 | $1,101,621 | 7 | 20th Century Fox International | false | false |
| 15 | 14 | Robin Hood | $5,720 | -41.1% | 9 | -1 | $635 | $1,414,177 | 11 | United International Pictures | false | false |
| 16 | 17 | Creation | $5,364 | -28.4% | 7 | - | $766 | $58,055 | 5 | Ster-Kinekor Pictures | false | false |
| 17 | 18 | Broken Embraces | $4,986 | -9.1% | 5 | - | $997 | $64,895 | 6 | Ster-Kinekor Pictures | false | false |
| 18 | - | Goal! III | $4,215 | - | 15 | - | $281 | $4,215 | 1 | United International Pictures | true | false |
| 19 | 19 | Themba | $3,766 | -8.1% | 10 | - | $376 | $10,494 | 2 | N/A | false | false |
| 20 | 15 | Milenge Milenge | $3,277 | -63.6% | 6 | - | $546 | $35,482 | 3 | N/A | false | false |
| 21 | 21 | The Back-up Plan | $3,093 | +2.6% | 6 | - | $515 | $752,219 | 12 | Sony Pictures Releasing | false | false |
| 22 | - | The Imaginarium of Doctor Parnassus | $3,003 | - | 4 | - | $750 | $68,911 | 7 | NuMetro Distribution | false | false |
| 23 | 23 | Iron Man 2 | $1,084 | -45.2% | 3 | -5 | $361 | $2,589,816 | 13 | Paramount Pictures International | false | false |
| 24 | - | For Better for Worse | $796 | - | 1 | - | $796 | $33,853 | 4 | N/A | false | false |
| 25 | 22 | Green Zone 2010 Re-release | $591 | -77.5% | 3 | -8 | $197 | $350,219 | 9 | United International Pictures | false | false |
