| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Shrek Forever After | $4,431,083 | - | 671 | - | $6,603 | $27,691,556 | 3 | Paramount Pictures International | false | false |
| 2 | - | Knight and Day 2010 Re-release | $1,465,884 | - | 316 | - | $4,638 | $5,488,270 | 2 | 20th Century Fox International | false | false |
| 3 | - | The Twilight Saga: Eclipse | $1,377,592 | - | 640 | - | $2,152 | $26,720,960 | 4 | Paris Filmes | false | false |
| 4 | - | The Well Beloved One | $895,386 | - | 156 | - | $5,739 | $895,386 | 1 | Walt Disney Pictures | true | false |
| 5 | 1 | Toy Story 3 | $776,473 | -23% | 327 | +3 | $2,374 | $21,594,592 | 6 | Walt Disney Pictures | false | false |
| 6 | - | Predators | $759,604 | - | 170 | - | $4,468 | $760,965 | 1 | 20th Century Fox International | true | false |
| 7 | - | Death Proof 2010 Re-release | $71,279 | - | 47 | - | $1,516 | $306,978 | 2 | PlayArte Pictures | false | false |
| 8 | - | Little Nicholas | $53,002 | - | 23 | - | $2,304 | $375,572 | 4 | N/A | false | false |
| 9 | 3 | Prince of Persia: The Sands of Time | $41,353 | -16.5% | 66 | -27 | $626 | $9,743,890 | 8 | Walt Disney Pictures | false | false |
| 10 | - | Whatever Works | $33,630 | - | 23 | - | $1,462 | $1,462,807 | 13 | N/A | false | false |
| 11 | - | Letters to Juliet | $29,494 | - | 11 | - | $2,681 | $1,741,099 | 7 | Paris Filmes | false | false |
| 12 | 2 | The Back-up Plan | $24,248 | -59.6% | 44 | -19 | $551 | $3,286,817 | 7 | Sony Pictures Releasing | false | false |
| 13 | - | The Young Victoria | $16,714 | - | 19 | - | $879 | $450,389 | 6 | Europa Filmes | false | false |
| 14 | - | I Love You Phillip Morris | $16,330 | - | 9 | - | $1,814 | $1,013,061 | 8 | N/A | false | false |
| 15 | - | Bright Star | $16,326 | - | 14 | - | $1,166 | $325,555 | 5 | PlayArte Pictures | false | false |
| 16 | - | Dear John | $14,747 | - | 12 | - | $1,228 | $224,196 | 12 | Sony Pictures Releasing | false | false |
| 17 | 4 | A Prophet | $14,354 | +56.2% | 5 | -1 | $2,870 | $123,240 | 6 | Sony Pictures Releasing | false | false |
| 18 | - | Cold Souls | $9,840 | - | 13 | - | $756 | $63,293 | 3 | Europa Filmes | false | false |
| 19 | - | The Ghost Writer | $7,598 | - | 12 | - | $633 | $703,084 | 9 | Paris Filmes | false | false |
| 20 | - | The Secret in Their Eyes | $7,580 | - | 17 | - | $445 | $1,735,258 | 22 | Europa Filmes | false | false |
| 21 | - | Daddy Cool 2010 Re-release | $7,289 | - | 4 | - | $1,822 | $64,673 | 4 | Pandora Filmes | false | false |
| 22 | 5 | The Two Deaths of Quincas Wateryell | $4,451 | -10.1% | 5 | - | $890 | $1,146,417 | 10 | Walt Disney Pictures | false | false |
| 23 | - | Desert Flower 2009 Re-release | $3,211 | - | 9 | - | $356 | $188,571 | 5 | N/A | false | false |
| 24 | - | The A-Team | $2,972 | - | 15 | - | $198 | $2,086,581 | 7 | 20th Century Fox International | false | false |
| 25 | - | Marmaduke | $2,813 | - | 9 | - | $312 | $916,569 | 8 | 20th Century Fox International | false | false |
| 26 | 6 | The Imaginarium of Doctor Parnassus | $1,366 | -12.9% | 3 | - | $455 | $144,092 | 12 | Sony Pictures Releasing | false | false |
| 27 | - | Kick-Ass | $631 | - | 3 | - | $210 | $259,701 | 6 | Universal Pictures International (UPI) | false | false |
| 28 | 9 | The Last Song | $558 | +402.7% | 2 | +1 | $279 | $96,679 | 7 | Walt Disney Pictures | false | false |
| 29 | - | Sex and the City 2 | $544 | - | 3 | - | $181 | $3,185,351 | 9 | Warner Bros. | false | false |
| 30 | - | Clash of the Titans | $502 | - | 4 | - | $125 | $15,883,574 | 10 | Warner Bros. | false | false |
| 31 | 7 | Alice in Wonderland | $414 | -57.2% | 3 | -6 | $138 | $26,730,382 | 14 | Walt Disney Pictures | false | false |
| 32 | 8 | Chico Xavier | $404 | -38.1% | 2 | - | $202 | $17,224,950 | 17 | Sony Pictures Releasing | false | false |
| 33 | - | The Greatest | $115 | - | 3 | - | $38 | $201,984 | 6 | PlayArte Pictures | false | false |
