| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Despicable Me | $356,090 | - | 72 | - | $4,945 | $356,090 | 1 | Universal Pictures International (UPI) | true | false |
| 2 | 2 | The Last Airbender | $274,583 | -64% | 79 | +2 | $3,475 | $1,334,308 | 2 | Paramount Pictures International | false | false |
| 3 | 1 | The Twilight Saga: Eclipse | $228,567 | -72.1% | 97 | - | $2,356 | $1,364,798 | 2 | N/A | false | false |
| 4 | 3 | Predators | $84,508 | -36.3% | 50 | +3 | $1,690 | $278,747 | 2 | 20th Century Fox International | false | false |
| 5 | 5 | Knight and Day 2010 Re-release | $16,186 | -20.1% | 46 | +40 | $351 | $577,861 | 4 | 20th Century Fox International | false | false |
| 6 | 4 | Toy Story 3 | $14,192 | -69% | 51 | -33 | $278 | $639,847 | 4 | Walt Disney Pictures | false | false |
| 7 | 6 | Avatar | $11,041 | -29.8% | 2 | -4 | $5,520 | $8,176,358 | 31 | 20th Century Fox International | false | false |
| 8 | 7 | The Alien Girl | $6,912 | -53.7% | 27 | -17 | $256 | $108,949 | 3 | N/A | false | false |
| 9 | 8 | Shrek Forever After | $4,418 | -34.1% | 11 | -25 | $401 | $3,956,094 | 9 | Paramount Pictures International | false | false |
| 10 | - | Splice 2010 Re-release | $3,080 | - | 12 | - | $256 | $73,304 | 4 | N/A | false | false |
| 11 | 9 | Prince of Persia: The Sands of Time | $2,068 | -65.2% | 30 | -12 | $68 | $1,573,865 | 7 | Walt Disney Pictures | false | false |
| 12 | 12 | Get Him to the Greek | $1,701 | -11.5% | 6 | -1 | $283 | $156,740 | 5 | Universal Pictures International (UPI) | false | false |
| 13 | 11 | Sex and the City 2 | $1,572 | -53.7% | 5 | -8 | $314 | $917,463 | 7 | Warner Bros. | false | false |
| 14 | 14 | Cop Out | $1,387 | +63.9% | 5 | -6 | $277 | $156,245 | 5 | Warner Bros. | false | false |
| 15 | 13 | The A-Team | $421 | -72% | 7 | -8 | $60 | $227,380 | 6 | 20th Century Fox International | false | false |
