| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Shrek Forever After | $871,418 | +91.7% | 230 | +4 | $3,788 | $2,366,691 | 2 | Universal Pictures International (UPI) | false | false |
| 2 | - | Knight and Day 2010 Re-release | $756,546 | - | 106 | - | $7,137 | $793,730 | 1 | Warner Bros. | true | false |
| 3 | 3 | Toy Story 3 | $491,932 | +117.3% | 188 | - | $2,616 | $2,381,035 | 4 | Walt Disney Pictures | false | false |
| 4 | 2 | The Twilight Saga: Eclipse | $326,223 | -11.9% | 105 | - | $3,106 | $2,816,673 | 3 | Independent Films | false | false |
| 5 | 4 | Sex and the City 2 | $95,514 | +16.8% | 90 | -24 | $1,061 | $4,885,276 | 8 | Warner Bros. | false | false |
| 6 | 5 | Unthinkable | $80,299 | +29.6% | 26 | - | $3,088 | $245,867 | 2 | A-Film Distribution | false | false |
| 7 | 6 | Get Him to the Greek | $70,788 | +17.5% | 39 | - | $1,815 | $364,567 | 3 | Universal Pictures International (UPI) | false | false |
| 8 | 7 | The A-Team | $53,348 | -10.8% | 62 | -29 | $860 | $1,515,429 | 6 | Warner Bros. | false | false |
| 9 | 9 | Letters to Juliet | $47,969 | +51% | 45 | -10 | $1,065 | $571,379 | 5 | Entertainment One | false | false |
| 10 | - | Furry Vengeance | $44,743 | - | 66 | - | $677 | $65,559 | 1 | Entertainment One | true | false |
| 11 | 8 | Killers | $39,582 | -11% | 42 | -18 | $942 | $1,216,791 | 7 | A-Film Distribution | false | false |
| 12 | 10 | The Back-up Plan | $33,313 | +5.8% | 26 | -12 | $1,281 | $597,507 | 5 | Sony Pictures Releasing | false | false |
| 13 | 11 | Prince of Persia: The Sands of Time | $32,491 | +13.4% | 26 | -24 | $1,249 | $2,521,779 | 9 | Walt Disney Pictures | false | false |
| 14 | 12 | Leap Year | $24,257 | +15.2% | 10 | - | $2,425 | $90,222 | 2 | Universal Pictures International (UPI) | false | false |
| 15 | 14 | Greenberg | $23,830 | +133.2% | 6 | - | $3,971 | $49,188 | 2 | Benelux Film Distributors | false | false |
| 16 | 13 | Robin Hood | $19,746 | +6.2% | 13 | -21 | $1,518 | $3,632,116 | 10 | Universal Pictures International (UPI) | false | false |
| 17 | 15 | The Ghost Writer | $19,358 | +197.8% | 9 | -7 | $2,150 | $536,324 | 9 | Benelux Film Distributors | false | false |
| 18 | 17 | Me Too | $14,818 | +202.2% | 13 | - | $1,139 | $300,310 | 10 | A-Film Distribution | false | false |
| 19 | 16 | Mao's Last Dancer | $13,019 | +163.4% | 13 | -1 | $1,001 | $91,237 | 5 | Wild Bunch Distribution | false | false |
| 20 | - | Me and Orson Welles | $8,101 | - | 5 | - | $1,620 | $10,578 | 1 | Moonlight Films | true | false |
| 21 | - | The Hairdresser | $7,357 | - | 11 | - | $668 | $7,357 | 1 | Paradiso Entertainment | true | false |
| 22 | - | The Last Summer of La Boyita | $2,770 | - | 4 | - | $692 | $2,770 | 1 | N/A | true | false |
