| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Iron Man 2 | $418,341 | - | 94 | - | $4,450 | $418,341 | 1 | United International Pictures | true | false |
| 2 | 1 | Clash of the Titans | $320,290 | -27.2% | 80 | -13 | $4,003 | $2,074,716 | 3 | Warner Bros. | false | false |
| 3 | 2 | Date Night | $105,411 | -9% | 44 | -5 | $2,395 | $904,865 | 4 | 20th Century Fox International | false | false |
| 4 | 3 | Paranormal Activity | $72,790 | +13.9% | 36 | -2 | $2,021 | $192,926 | 2 | N/A | false | false |
| 5 | 4 | How to Train Your Dragon | $51,079 | -13.8% | 45 | -16 | $1,135 | $1,591,317 | 6 | United International Pictures | false | false |
| 6 | 7 | Alice in Wonderland | $27,969 | -15.6% | 31 | -19 | $902 | $4,278,753 | 9 | Walt Disney Pictures | false | false |
| 7 | 8 | Dear John | $25,056 | -23.9% | 15 | - | $1,670 | $75,819 | 2 | Sony Pictures Releasing | false | false |
| 8 | 5 | Did You Hear About the Morgans? | $20,334 | -57.7% | 21 | -15 | $968 | $233,090 | 3 | Sony Pictures Releasing | false | false |
| 9 | 9 | Case 39 | $17,629 | -30.1% | 15 | -8 | $1,175 | $226,913 | 4 | United International Pictures | false | false |
| 10 | 6 | The Bounty Hunter | $14,522 | -60.1% | 15 | -12 | $968 | $645,005 | 5 | Sony Pictures Releasing | false | false |
| 11 | 11 | The Imaginarium of Doctor Parnassus | $12,313 | -26.3% | 10 | - | $1,231 | $79,253 | 3 | Sony Pictures Releasing | false | false |
| 12 | 10 | The Book of Eli | $10,002 | -55.8% | 9 | -14 | $1,111 | $988,786 | 6 | Sony Pictures Releasing | false | false |
| 13 | 12 | I Hate Valentine's Day | $8,990 | -46% | 10 | -5 | $899 | $87,443 | 3 | N/A | false | false |
| 14 | 14 | Everybody's Fine | $8,963 | -0.9% | 7 | -3 | $1,280 | $84,159 | 4 | Walt Disney Pictures | false | false |
| 15 | - | A Prophet | $8,937 | - | 3 | - | $2,979 | $14,701 | 1 | Sony Pictures Releasing | true | false |
| 16 | 13 | Street Fighter: The Legend of Chun-Li | $3,554 | -68.4% | 12 | -2 | $296 | $27,147 | 2 | N/A | false | false |
| 17 | 16 | The Haunting in Connecticut | $3,252 | -4.6% | 4 | -3 | $813 | $264,791 | 6 | N/A | false | false |
| 18 | 17 | 500 Days of Summer | $1,560 | -50.1% | 2 | -1 | $780 | $88,208 | 6 | 20th Century Fox International | false | false |
| 19 | 15 | Couples Retreat | $1,148 | -78% | 2 | -7 | $574 | $368,077 | 6 | United International Pictures | false | false |
| 20 | 18 | Old Dogs | $582 | -70.6% | 2 | -5 | $291 | $2,468,108 | 13 | United International Pictures | false | false |
| 21 | 23 | The Return 2010 Re-release | $409 | +26.6% | 1 | - | $409 | $119,195 | 10 | N/A | false | false |
| 22 | 20 | Feast 2010 Re-release | $343 | -77.6% | 1 | -1 | $343 | $25,920 | 7 | N/A | false | false |
