| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Clash of the Titans | $776,251 | -23.6% | 153 | -26 | $5,073 | $3,703,589 | 3 | Warner Bros. | false | false |
| 2 | - | Iron Man 2 | $392,374 | - | 87 | - | $4,510 | $392,374 | 1 | United International Pictures | true | false |
| 3 | - | The Girl with the Dragon Tattoo | $100,854 | - | 70 | - | $1,440 | $100,854 | 1 | Cine Colombia | true | false |
| 4 | 2 | How to Train Your Dragon | $65,329 | -47.1% | 75 | -33 | $871 | $1,782,487 | 6 | United International Pictures | false | false |
| 5 | 3 | Alice in Wonderland | $60,143 | -32.5% | 58 | -41 | $1,036 | $6,630,742 | 9 | Walt Disney Pictures | false | false |
| 6 | 4 | Legion | $54,846 | -26.2% | 42 | -8 | $1,305 | $545,994 | 4 | Sony Pictures Releasing | false | false |
| 7 | 5 | It's Complicated | $33,687 | -45.1% | 23 | -27 | $1,464 | $234,616 | 3 | United International Pictures | false | false |
| 8 | - | The Last Song | $29,919 | - | 16 | - | $1,869 | $29,919 | 1 | Walt Disney Pictures | true | false |
| 9 | 7 | Cell 211 | $22,337 | -41.6% | 24 | -5 | $930 | $140,117 | 3 | Cineplex | false | false |
| 10 | - | Gamer | $22,229 | - | 17 | - | $1,307 | $22,229 | 1 | Cineplex | true | false |
| 11 | 8 | Shutter Island | $17,222 | -41.5% | 14 | -11 | $1,230 | $503,578 | 8 | United International Pictures | false | false |
| 12 | 6 | Dear John | $14,545 | -63.2% | 12 | -18 | $1,212 | $65,193 | 2 | Sony Pictures Releasing | false | false |
| 13 | 9 | The Wave | $11,620 | -27.4% | 7 | -1 | $1,660 | $35,446 | 2 | Cine Colombia | false | false |
| 14 | 13 | The Hurt Locker | $7,300 | +15.5% | 8 | +2 | $912 | $2,582,973 | 12 | Cineplex | false | false |
| 15 | - | Grace Is Gone | $6,640 | - | 7 | - | $948 | $6,640 | 1 | Cine Colombia | true | false |
| 16 | - | Seraphine | $6,180 | - | 10 | - | $618 | $6,180 | 1 | Cineplex | true | false |
| 17 | 10 | Let the Right One In | $6,095 | -59.3% | 9 | -1 | $677 | $26,819 | 2 | Cine Colombia | false | false |
| 18 | 19 | Old Dogs | $2,716 | +38.5% | 3 | +1 | $905 | $1,158,809 | 17 | Walt Disney Pictures | false | false |
| 19 | 11 | Case 39 | $2,026 | -86.2% | 5 | -21 | $405 | $154,747 | 4 | United International Pictures | false | false |
| 20 | 15 | Tooth Fairy | $1,778 | -57.1% | 6 | -4 | $296 | $1,111,561 | 15 | 20th Century Fox International | false | false |
| 21 | 14 | Mongol: The Rise of Genghis Khan | $1,615 | -63.6% | 2 | -5 | $807 | $48,121 | 4 | Cine Colombia | false | false |
| 22 | 20 | Couples Retreat | $1,071 | -42.1% | 1 | -3 | $1,071 | $227,269 | 10 | United International Pictures | false | false |
| 23 | 23 | Away We Go | $992 | -2.9% | 1 | -1 | $992 | $10,936 | 4 | United International Pictures | false | false |
| 24 | 12 | The Book of Eli | $977 | -89.4% | 2 | -11 | $488 | $1,010,996 | 7 | Sony Pictures Releasing | false | false |
| 25 | 18 | [Rec]² | $759 | -63.2% | 2 | - | $379 | $246,451 | 9 | Cine Colombia | false | false |
| 26 | 16 | Precious | $750 | -81.6% | 4 | -1 | $187 | $307,036 | 11 | Cine Colombia | false | false |
