| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Iron Man 2 | $754,268 | - | 83 | - | $9,087 | $754,268 | 1 | Paramount Pictures International | true | false |
| 2 | 1 | Clash of the Titans | $406,229 | -46.7% | 106 | +4 | $3,832 | $2,928,690 | 3 | Warner Bros. | false | false |
| 3 | 3 | Brother and Sister | $96,201 | -47% | 69 | +2 | $1,394 | $1,628,854 | 5 | Primer Plano Film Group | false | false |
| 4 | 4 | Alice in Wonderland | $82,948 | -35.5% | 89 | - | $932 | $7,928,785 | 9 | Walt Disney Pictures | false | false |
| 5 | 5 | How to Train Your Dragon | $60,577 | -40.9% | 90 | -12 | $673 | $1,691,250 | 6 | Paramount Pictures International | false | false |
| 6 | 6 | The Men Who Stare at Goats | $38,901 | -52.3% | 30 | - | $1,296 | $136,399 | 2 | Sony Pictures Releasing | false | false |
| 7 | 7 | The White Ribbon | $32,365 | -43.8% | 15 | - | $2,157 | $104,084 | 2 | N/A | false | false |
| 8 | 8 | Shutter Island | $32,267 | -41.4% | 40 | -3 | $806 | $1,530,275 | 8 | Paramount Pictures International | false | false |
| 9 | 12 | Remember Me | $27,720 | -29.6% | 27 | -1 | $1,026 | $230,890 | 4 | Alfa Films | false | false |
| 10 | 10 | A Single Man | $21,824 | -53% | 13 | - | $1,678 | $77,117 | 2 | N/A | false | false |
| 11 | 11 | It's Alive | $21,803 | -49% | 21 | - | $1,038 | $74,273 | 2 | Distribution Company | false | false |
| 12 | 9 | Date Night | $19,358 | -61.9% | 30 | -11 | $645 | $336,530 | 4 | 20th Century Fox International | false | false |
| 13 | - | Synecdoche, New York | $18,750 | - | 10 | - | $1,875 | $18,750 | 1 | Distribution Company | true | false |
| 14 | 14 | Case 39 | $17,951 | -51% | 29 | -1 | $619 | $239,407 | 4 | Paramount Pictures International | false | false |
| 15 | 16 | Ex | $17,738 | -51.5% | 16 | -3 | $1,108 | $61,220 | 2 | Primer Plano Film Group | false | false |
| 16 | 13 | Love Happens | $13,493 | -65% | 29 | -4 | $465 | $146,908 | 3 | Distribution Company | false | false |
| 17 | - | The Beaches of Agnès | $13,235 | - | 6 | - | $2,205 | $13,235 | 1 | IFA | true | false |
| 18 | 25 | Avatar | $11,038 | +56.9% | 3 | +1 | $3,679 | $13,427,587 | 18 | 20th Century Fox International | false | false |
| 19 | 19 | The Fourth Kind | $7,241 | -50.4% | 12 | -3 | $603 | $162,835 | 5 | Alfa Films | false | false |
| 20 | 20 | Seraphine | $5,903 | -52.7% | 7 | -4 | $843 | $98,883 | 5 | N/A | false | false |
| 21 | 18 | The Box | $4,538 | -71.5% | 9 | -9 | $504 | $63,458 | 3 | Alfa Films | false | false |
| 22 | 22 | The Blind Side | $4,334 | -58.1% | 22 | -5 | $197 | $299,462 | 7 | Warner Bros. | false | false |
| 23 | - | Ricky | $4,329 | - | 8 | - | $541 | $4,329 | 1 | Impacto Cine | true | false |
| 24 | 21 | The Bounty Hunter | $3,636 | -70.3% | 12 | -11 | $303 | $327,573 | 5 | Sony Pictures Releasing | false | false |
| 25 | 32 | Couples Retreat | $3,582 | +127.7% | 3 | -2 | $1,194 | $165,971 | 9 | Universal Pictures International (UPI) | false | false |
| 26 | 23 | The Book of Eli | $3,469 | -58.5% | 18 | -7 | $192 | $585,442 | 7 | Sony Pictures Releasing | false | false |
| 27 | 26 | The Rebound | $2,869 | -58% | 7 | -4 | $409 | $122,617 | 6 | Alfa Films | false | false |
| 28 | 29 | Remembering the Children | $2,721 | +4.8% | 8 | - | $340 | $55,435 | 4 | Distribution Company | false | false |
| 29 | 24 | Everybody's Fine | $2,406 | -68.8% | 8 | -8 | $300 | $188,543 | 7 | Walt Disney Pictures | false | false |
| 30 | 27 | Edge of Darkness | $2,363 | -27.2% | 5 | -5 | $472 | $1,140,999 | 10 | Warner Bros. | false | false |
| 31 | 17 | Dear John | $2,060 | -89.7% | 7 | -18 | $294 | $67,935 | 3 | Sony Pictures Releasing | false | false |
| 32 | 28 | Precious | $1,126 | -60.5% | 4 | -5 | $281 | $301,454 | 12 | N/A | false | false |
| 33 | - | Did You Hear About the Morgans? | $625 | - | 2 | - | $312 | $283,449 | 8 | Sony Pictures Releasing | false | false |
| 34 | 33 | Paco | $562 | -58.3% | 5 | -1 | $112 | $182,016 | 7 | Primer Plano Film Group | false | false |
| 35 | 39 | The Hurt Locker | $555 | +0.5% | 3 | - | $185 | $791,443 | 13 | Distribution Company | false | false |
| 36 | 31 | Alvin and the Chipmunks: The Squeakquel | $465 | -70.5% | 1 | -1 | $465 | $1,088,725 | 15 | 20th Century Fox International | false | false |
| 37 | 30 | Bad Lieutenant: Port of Call New Orleans | $404 | -78.1% | 1 | -3 | $404 | $175,545 | 9 | Distribution Company | false | false |
| 38 | 44 | The Wolfman | $267 | +159.2% | 1 | - | $267 | $1,121,565 | 12 | Universal Pictures International (UPI) | false | false |
| 39 | 2 | Brothers | $253 | -99.9% | 3 | -64 | $84 | $1,493,496 | 6 | Distribution Company | false | false |
| 40 | 45 | Astro Boy | $231 | +175% | 1 | - | $231 | $174,402 | 14 | Alfa Films | false | false |
| 41 | 47 | Birds of Paradise | $203 | +1,461.5% | 1 | - | $203 | $194,112 | 11 | Sony Pictures Releasing | false | false |
| 42 | 36 | Crazy Heart | $186 | -79.6% | 1 | -5 | $186 | $107,415 | 8 | 20th Century Fox International | false | false |
| 43 | - | The Girl with the Dragon Tattoo | $77 | - | 1 | - | $77 | $278,936 | 11 | N/A | false | false |
| 44 | 35 | 9 | $44 | -96.5% | 1 | -6 | $44 | $38,814 | 7 | Distribution Company | false | false |
| 45 | 34 | Fame | $25 | -98% | 1 | -3 | $25 | $57,537 | 5 | Impacto Cine | false | false |
| 46 | 46 | Old Dogs | $18 | -55% | 1 | - | $18 | $1,506,289 | 15 | Walt Disney Pictures | false | false |
