| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Clash of the Titans | $536,976 | - | 91 | - | $5,900 | $536,976 | 1 | Warner Bros. | true | false |
| 2 | 1 | Date Night | $143,929 | -27.7% | 52 | -9 | $2,767 | $469,470 | 2 | 20th Century Fox International | false | false |
| 3 | 3 | How to Train Your Dragon | $88,818 | -42.8% | 66 | -10 | $1,345 | $1,371,087 | 4 | United International Pictures | false | false |
| 4 | - | Did You Hear About the Morgans? | $74,919 | - | 40 | - | $1,872 | $74,919 | 1 | Sony Pictures Releasing | true | false |
| 5 | 5 | The Bounty Hunter | $67,083 | -31% | 39 | -1 | $1,720 | $501,910 | 3 | Sony Pictures Releasing | false | false |
| 6 | 2 | Alice in Wonderland | $63,622 | -59.7% | 57 | -12 | $1,116 | $4,137,310 | 7 | Walt Disney Pictures | false | false |
| 7 | 4 | The Book of Eli | $50,255 | -54.9% | 38 | -19 | $1,322 | $903,350 | 4 | Sony Pictures Releasing | false | false |
| 8 | 6 | Case 39 | $31,492 | -45% | 27 | -2 | $1,166 | $130,172 | 2 | United International Pictures | false | false |
| 9 | - | The Imaginarium of Doctor Parnassus | $23,127 | - | 10 | - | $2,312 | $23,127 | 1 | Sony Pictures Releasing | true | false |
| 10 | - | I Hate Valentine's Day | $23,005 | - | 14 | - | $1,643 | $23,005 | 1 | N/A | true | false |
| 11 | 7 | Couples Retreat | $10,788 | -67.9% | 14 | -17 | $770 | $348,014 | 4 | United International Pictures | false | false |
| 12 | 9 | The Haunting in Connecticut | $10,454 | -49.3% | 11 | -7 | $950 | $246,444 | 4 | N/A | false | false |
| 13 | 13 | 500 Days of Summer | $5,478 | -52% | 4 | -3 | $1,369 | $75,703 | 4 | 20th Century Fox International | false | false |
| 14 | 8 | Everybody's Fine | $4,117 | -86% | 5 | -12 | $823 | $47,773 | 2 | Walt Disney Pictures | false | false |
| 15 | 11 | Old Dogs | $3,852 | -74.4% | 11 | -16 | $350 | $2,459,331 | 11 | United International Pictures | false | false |
| 16 | 10 | The Blind Side | $3,306 | -82% | 4 | -15 | $826 | $351,100 | 5 | Warner Bros. | false | false |
| 17 | 12 | Shutter Island | $2,874 | -80.5% | 6 | -15 | $479 | $631,921 | 6 | United International Pictures | false | false |
| 18 | 18 | Desautorizados | $2,773 | -1.1% | 6 | -2 | $462 | $53,161 | 4 | N/A | false | false |
| 19 | 16 | The Return 2010 Re-release | $1,865 | -46.4% | 3 | -1 | $621 | $115,786 | 8 | N/A | false | false |
| 20 | 14 | Edge of Darkness | $1,672 | -84.2% | 3 | -11 | $557 | $828,534 | 7 | Warner Bros. | false | false |
| 21 | 15 | Feast 2010 Re-release | $1,649 | -74.5% | 1 | -1 | $1,649 | $20,952 | 5 | N/A | false | false |
