| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Dear John | $3,066,392 | - | 402 | - | $7,627 | $3,066,392 | 1 | Paramount Pictures International | true | false |
| 2 | 1 | Clash of the Titans | $2,392,860 | -36.3% | 461 | -7 | $5,190 | $250,093,043 | 3 | Warner Bros. | false | false |
| 3 | 2 | How to Train Your Dragon | $1,970,984 | -8.4% | 490 | +12 | $4,022 | $20,115,904 | 3 | Paramount Pictures International | false | false |
| 4 | 3 | Kick-Ass | $1,399,190 | -23.6% | 424 | +19 | $3,299 | $13,893,751 | 3 | Universal Pictures International (UPI) | false | false |
| 5 | 4 | Nanny McPhee Returns | $1,332,319 | -26.6% | 511 | -18 | $2,607 | $22,386,020 | 4 | Universal Pictures International (UPI) | false | false |
| 6 | - | The Ghost Writer | $1,311,939 | - | 332 | - | $3,951 | $1,311,939 | 1 | Optimum Releasing | true | false |
| 7 | - | Cemetery Junction | $985,428 | - | 330 | - | $2,986 | $985,428 | 1 | Sony Pictures Releasing | true | false |
| 8 | 5 | Alice in Wonderland | $766,787 | -26.3% | 410 | -48 | $1,870 | $63,659,611 | 7 | Walt Disney Pictures | false | false |
| 9 | 6 | The Blind Side | $459,627 | -44.5% | 320 | -48 | $1,436 | $8,652,430 | 4 | Warner Bros. | false | false |
| 10 | 7 | Remember Me | $346,392 | -56.8% | 344 | -20 | $1,006 | $5,168,880 | 3 | Entertainment One | false | false |
| 11 | - | Repo Men | $280,925 | - | 243 | - | $1,156 | $280,925 | 1 | Universal Pictures International (UPI) | true | false |
| 12 | 9 | Shutter Island | $275,453 | -46.8% | 193 | -122 | $1,427 | $16,030,638 | 6 | Paramount Pictures International | false | false |
| 13 | 14 | The Infidel | $184,803 | -11.3% | 56 | +27 | $3,300 | $492,093 | 2 | Revolver Entertainment | false | false |
| 14 | 11 | I Am Love | $174,186 | -34.1% | 47 | +12 | $3,706 | $620,954 | 2 | - | false | false |
| 15 | 13 | The Spy Next Door 2010 Re-release | $162,460 | -23.2% | 233 | -60 | $697 | $3,971,159 | 5 | Paramount Pictures International | false | false |
