| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Clash of the Titans | $1,016,548 | -21.9% | 179 | -7 | $5,679 | $2,746,266 | 2 | Warner Bros. | false | false |
| 2 | 3 | How to Train Your Dragon | $123,540 | +31.3% | 108 | +21 | $1,143 | $1,749,805 | 5 | United International Pictures | false | false |
| 3 | 5 | Alice in Wonderland | $89,140 | +28.7% | 99 | +6 | $900 | $6,743,542 | 8 | Walt Disney Pictures | false | false |
| 4 | 2 | Legion | $74,297 | -28.1% | 50 | - | $1,485 | $467,922 | 3 | Sony Pictures Releasing | false | false |
| 5 | 4 | It's Complicated | $61,339 | -30.2% | 50 | - | $1,226 | $182,910 | 2 | United International Pictures | false | false |
| 6 | - | Dear John | $39,542 | - | 30 | - | $1,318 | $39,542 | 1 | Sony Pictures Releasing | true | false |
| 7 | 6 | Cell 211 | $38,244 | -21.4% | 29 | -2 | $1,318 | $107,144 | 2 | Cineplex | false | false |
| 8 | 9 | Shutter Island | $29,420 | +124.2% | 25 | +2 | $1,176 | $487,393 | 7 | United International Pictures | false | false |
| 9 | - | The Wave | $16,009 | - | 8 | - | $2,001 | $16,009 | 1 | Cine Colombia | true | false |
| 10 | - | Let the Right One In | $14,993 | - | 10 | - | $1,499 | $14,993 | 1 | Cine Colombia | true | false |
| 11 | 7 | Case 39 | $14,678 | -52.5% | 26 | -11 | $564 | $145,929 | 3 | United International Pictures | false | false |
| 12 | 8 | The Book of Eli | $9,203 | -68% | 13 | -32 | $707 | $1,006,430 | 6 | Sony Pictures Releasing | false | false |
| 13 | 13 | The Hurt Locker | $6,322 | +87.1% | 6 | -3 | $1,053 | $255,716 | 11 | Cineplex | false | false |
| 14 | 11 | Mongol: The Rise of Genghis Khan | $4,440 | -54.4% | 7 | -1 | $634 | $45,387 | 3 | Cine Colombia | false | false |
| 15 | 20 | Tooth Fairy | $4,145 | +299.7% | 10 | +4 | $414 | $1,140,340 | 14 | 20th Century Fox International | false | false |
| 16 | 25 | Precious | $4,078 | +462.5% | 5 | +3 | $815 | $304,473 | 10 | Cine Colombia | false | false |
| 17 | 12 | Smother | $2,093 | -76.2% | 6 | -4 | $348 | $13,483 | 2 | Cine Colombia | false | false |
| 18 | 14 | [Rec]² | $2,060 | -29.6% | 2 | -5 | $1,030 | $251,940 | 8 | Cine Colombia | false | false |
| 19 | 16 | Old Dogs | $1,961 | +2.1% | 2 | -1 | $980 | $1,188,981 | 16 | Walt Disney Pictures | false | false |
| 20 | 22 | Couples Retreat | $1,849 | +118.8% | 4 | +1 | $462 | $225,095 | 9 | United International Pictures | false | false |
| 21 | 10 | The Blind Side | $1,706 | -86.3% | 4 | -12 | $426 | $382,314 | 5 | Warner Bros. | false | false |
| 22 | 15 | Remember Me | $1,406 | -42.4% | 2 | -3 | $703 | $166,540 | 5 | Cine Colombia | false | false |
| 23 | 17 | Away We Go | $1,022 | -42.9% | 2 | -1 | $511 | $9,638 | 3 | United International Pictures | false | false |
| 24 | 19 | The Anarchist's Wife | $623 | -45% | 1 | -1 | $623 | $28,707 | 5 | Cineplex | false | false |
