| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Clash of the Titans | $67,628,501 | - | 3,777 | - | $17,905 | $70,283,506 | 1 | Warner Bros. | true | false |
| 2 | - | How to Train Your Dragon | $34,296,083 | - | 4,060 | - | $8,447 | $97,421,955 | 2 | DreamWorks | false | false |
| 3 | - | Why Did I Get Married Too? | $32,252,558 | - | 2,155 | - | $14,966 | $32,252,558 | 1 | Lionsgate | true | false |
| 4 | - | The Last Song | $18,345,593 | - | 2,673 | - | $6,863 | $27,733,208 | 1 | Walt Disney Studios Motion Pictures | true | false |
| 5 | - | Alice in Wonderland | $9,439,908 | - | 2,980 | - | $3,167 | $310,965,601 | 5 | Walt Disney Studios Motion Pictures | false | false |
| 6 | - | Hot Tub Time Machine | $9,015,403 | - | 2,771 | - | $3,253 | $28,854,900 | 2 | Metro-Goldwyn-Mayer (MGM) | false | false |
| 7 | - | The Bounty Hunter | $6,854,238 | - | 3,118 | - | $2,198 | $49,615,784 | 3 | Sony Pictures Releasing | false | false |
| 8 | - | Diary of a Wimpy Kid | $6,486,070 | - | 2,842 | - | $2,282 | $47,197,048 | 3 | Twentieth Century Fox | false | false |
| 9 | - | She's Out of My League | $1,720,273 | - | 1,390 | - | $1,237 | $28,916,295 | 4 | Paramount Pictures | false | false |
| 10 | - | Shutter Island | $1,672,692 | - | 1,356 | - | $1,233 | $123,625,226 | 7 | Paramount Pictures | false | false |
| 11 | - | Green Zone | $1,397,620 | - | 1,242 | - | $1,125 | $33,267,645 | 4 | Universal Pictures | false | false |
| 12 | - | The Ghost Writer | $1,247,979 | - | 656 | - | $1,902 | $11,136,875 | 7 | Summit Entertainment | false | false |
| 13 | - | Avatar | $1,145,503 | - | 511 | - | $2,241 | $742,497,942 | 16 | Twentieth Century Fox | false | false |
| 14 | - | Our Family Wedding | $924,658 | - | 722 | - | $1,280 | $18,700,816 | 4 | - | false | false |
| 15 | - | Greenberg | $780,678 | - | 186 | - | $4,197 | $2,349,302 | 3 | Focus Features | false | false |
| 16 | - | Repo Men | $654,845 | - | 873 | - | $750 | $13,234,920 | 3 | Universal Pictures | false | false |
| 17 | - | Hubble | $571,709 | - | 40 | - | $14,292 | $2,103,666 | 3 | Warner Bros. | false | false |
| 18 | - | Remember Me | $559,742 | - | 906 | - | $617 | $18,319,975 | 4 | Summit Entertainment | false | false |
| 19 | - | Percy Jackson & the Olympians: The Lightning Thief | $371,938 | - | 412 | - | $902 | $86,744,135 | 8 | Twentieth Century Fox | false | false |
| 20 | - | Crazy Heart | $355,611 | - | 435 | - | $817 | $38,384,152 | 16 | - | false | false |
| 21 | - | The Crazies | $288,930 | - | 415 | - | $696 | $38,273,304 | 6 | Overture Films | false | false |
| 22 | - | Cop Out | $285,239 | - | 229 | - | $1,245 | $44,067,151 | 6 | Warner Bros. | false | false |
| 23 | - | The Blind Side | $258,946 | - | 316 | - | $819 | $255,522,074 | 20 | Warner Bros. | false | false |
| 24 | - | Tooth Fairy | $223,539 | - | 272 | - | $821 | $58,604,240 | 11 | Twentieth Century Fox | false | false |
| 25 | - | The Book of Eli | $211,811 | - | 218 | - | $971 | $94,278,079 | 12 | Warner Bros. | false | false |
| 26 | - | Brooklyn's Finest | $195,009 | - | 301 | - | $647 | $26,767,669 | 5 | Overture Films | false | false |
| 27 | - | The Runaways | $190,590 | - | 84 | - | $2,268 | $1,980,127 | 3 | Apparition | false | false |
| 28 | - | Sherlock Holmes | $187,349 | - | 232 | - | $807 | $208,733,110 | 15 | Warner Bros. | false | false |
| 29 | - | Alvin and the Chipmunks: The Squeakquel | $162,955 | - | 255 | - | $639 | $219,332,115 | 15 | Twentieth Century Fox | false | false |
| 30 | - | City Island | $155,264 | - | 27 | - | $5,750 | $268,630 | 3 | Anchor Bay Films | false | false |
| 31 | - | Dear John | $153,553 | - | 266 | - | $577 | $79,602,353 | 9 | Screen Gems | false | false |
| 32 | - | Valentine's Day | $90,165 | - | 96 | - | $939 | $110,005,822 | 8 | Warner Bros. | false | false |
| 33 | - | Under the Sea 3D | $78,645 | - | 16 | - | $4,915 | $21,327,019 | 60 | Warner Bros. | false | false |
| 34 | - | The Secret of Kells | $64,251 | - | 18 | - | $3,569 | $194,121 | 5 | GKIDS | false | false |
| 35 | - | Edge of Darkness | $42,506 | - | 126 | - | $337 | $43,296,223 | 10 | Warner Bros. | false | false |
| 36 | - | The Young Victoria | $33,061 | - | 50 | - | $661 | $10,866,764 | 16 | Apparition | false | false |
| 37 | - | A Single Man | $31,944 | - | 71 | - | $449 | $9,102,857 | 17 | The Weinstein Company | false | false |
| 38 | - | Up in the Air | $21,285 | - | 41 | - | $519 | $83,816,643 | 18 | Paramount Pictures | false | false |
| 39 | - | Waking Sleeping Beauty | $16,768 | - | 5 | - | $3,353 | $62,540 | 2 | Walt Disney Studios Motion Pictures | false | false |
| 40 | - | Don McKay | $9,827 | - | 7 | - | $1,403 | $9,827 | 1 | Image Entertainment | true | false |
| 41 | - | Breath Made Visible: Anna Halprin | $9,354 | - | 3 | - | $3,118 | $9,354 | 1 | Argot Pictures | true | false |
| 42 | - | My Name Is Khan | $8,323 | - | 8 | - | $1,040 | $4,004,277 | 8 | - | false | false |
| 43 | - | That Evening Sun | $4,740 | - | 7 | - | $677 | $237,045 | 22 | Freestyle Releasing | false | false |
| 44 | - | Ca$h | $521 | - | 3 | - | $173 | $27,439 | 2 | Roadside Attractions | false | false |
