| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | How to Train Your Dragon | $215,179 | -51.4% | 59 | - | $3,647 | $1,229,304 | 3 | Paramount Pictures International | false | false |
| 2 | - | The Book of Eli | $100,309 | - | 24 | - | $4,179 | $100,309 | 1 | Sony Pictures Releasing | true | false |
| 3 | 2 | Legion | $96,263 | -52.9% | 27 | - | $3,565 | $356,516 | 2 | Sony Pictures Releasing | false | false |
| 4 | - | Case 39 | $93,514 | - | 34 | - | $2,750 | $93,514 | 1 | Paramount Pictures International | true | false |
| 5 | 3 | It's Complicated | $63,703 | -50.4% | 30 | - | $2,123 | $232,528 | 2 | Universal Pictures International (UPI) | false | false |
| 6 | 4 | Alice in Wonderland | $58,213 | -48.7% | 53 | - | $1,098 | $1,774,641 | 6 | Walt Disney Pictures | false | false |
| 7 | 5 | The Blind Side | $33,569 | -50.2% | 18 | - | $1,864 | $271,351 | 3 | Warner Bros. | false | false |
| 8 | 6 | Let the Right One In | $24,907 | -59.5% | 15 | - | $1,660 | $103,819 | 2 | N/A | false | false |
| 9 | 9 | My Best Friend's Girl | $20,712 | -9.3% | 27 | - | $767 | $248,524 | 4 | N/A | false | false |
| 10 | 7 | Shutter Island | $12,284 | -63.6% | 32 | - | $383 | $543,765 | 5 | Paramount Pictures International | false | false |
| 11 | - | Transsiberian | $10,745 | - | 6 | - | $1,790 | $10,745 | 1 | N/A | true | false |
| 12 | - | Paris 36 | $10,474 | - | 5 | - | $2,094 | $10,474 | 1 | N/A | true | false |
| 13 | 10 | The Hurt Locker | $9,533 | -55.5% | 15 | - | $635 | $354,417 | 8 | N/A | false | false |
| 14 | 12 | All About Steve | $6,607 | -59.5% | 21 | - | $314 | $144,817 | 5 | 20th Century Fox International | false | false |
| 15 | 13 | Edge of Darkness | $3,157 | -75% | 28 | - | $112 | $404,730 | 7 | Warner Bros. | false | false |
| 16 | 20 | Precious | $3,068 | +101.6% | 7 | - | $438 | $104,678 | 7 | N/A | false | false |
| 17 | 11 | Eden Lake | $2,473 | -88.1% | 16 | - | $154 | $92,072 | 3 | N/A | false | false |
| 18 | 8 | Fame | $1,965 | -92.8% | 25 | - | $78 | $38,017 | 2 | N/A | false | false |
| 19 | 14 | Did You Hear About the Morgans? | $1,854 | -76.1% | 4 | -4 | $463 | $116,867 | 4 | Sony Pictures Releasing | false | false |
| 20 | - | Extraordinary Measures | $1,512 | - | 2 | - | $756 | $55,490 | 5 | Sony Pictures Releasing | false | false |
| 21 | - | The Stepfather | $1,205 | - | 1 | - | $1,205 | $124,464 | 13 | Sony Pictures Releasing | false | false |
| 22 | 24 | Saw VI | $838 | +61.2% | 25 | - | $33 | $211,461 | 8 | Walt Disney Pictures | false | false |
| 23 | 23 | The Box | $522 | -47.1% | 16 | - | $32 | $61,779 | 6 | N/A | false | false |
| 24 | 28 | Diary of a Nymphomaniac | $429 | +187.9% | 10 | - | $42 | $81,876 | 31 | N/A | false | false |
| 25 | 21 | All the Boys Love Mandy Lane | $360 | -73.7% | 14 | - | $25 | $136,342 | 10 | N/A | false | false |
| 26 | 17 | Percy Jackson & the Olympians: The Lightning Thief | $224 | -92.4% | 43 | - | $5 | $966,880 | 9 | 20th Century Fox International | false | false |
| 27 | 19 | Old Dogs | $184 | -90.2% | 42 | - | $4 | $1,163,243 | 11 | Walt Disney Pictures | false | false |
| 28 | - | Broken Embraces | $180 | - | 15 | - | $12 | $45,245 | 6 | Universal Pictures International (UPI) | false | false |
| 29 | 18 | An American Crime | $159 | -94.3% | 14 | - | $11 | $97,730 | 4 | N/A | false | false |
| 30 | - | Dan in Real Life | $50 | - | 12 | - | $4 | $94,533 | 45 | N/A | false | false |
