| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Clash of the Titans | $8,643,945 | - | 446 | - | $19,381 | $8,643,945 | 1 | Warner Bros. | true | false |
| 2 | - | How to Train Your Dragon | $7,371,824 | - | 471 | - | $15,651 | $7,371,824 | 1 | Paramount Pictures International | true | false |
| 3 | - | Kick-Ass | $5,904,271 | - | 402 | - | $14,687 | $5,904,271 | 1 | Universal Pictures International (UPI) | true | false |
| 4 | 1 | Nanny McPhee Returns | $3,955,765 | +2.6% | 521 | +9 | $7,592 | $10,878,511 | 2 | Universal Pictures International (UPI) | false | false |
| 5 | 2 | Alice in Wonderland | $1,955,903 | -47.4% | 438 | -72 | $4,465 | $57,708,888 | 5 | Walt Disney Pictures | false | false |
| 6 | 3 | The Blind Side | $1,526,915 | -22% | 368 | -3 | $4,149 | $5,176,577 | 2 | Warner Bros. | false | false |
| 7 | - | Remember Me | $1,501,749 | - | 354 | - | $4,242 | $1,501,749 | 1 | Entertainment One | true | false |
| 8 | 4 | Shutter Island | $1,073,100 | -37.2% | 307 | -111 | $3,495 | $13,932,846 | 4 | Paramount Pictures International | false | false |
| 9 | 5 | The Bounty Hunter | $776,097 | -47.6% | 317 | -76 | $2,448 | $7,824,603 | 3 | Sony Pictures Releasing | false | false |
| 10 | 7 | The Spy Next Door 2010 Re-release | $390,746 | -33.4% | 305 | -25 | $1,281 | $2,700,907 | 3 | Paramount Pictures International | false | false |
| 11 | 6 | Green Zone | $259,344 | -62.6% | 134 | -211 | $1,935 | $8,259,161 | 4 | Universal Pictures International (UPI) | false | false |
| 12 | 11 | The Girl with the Dragon Tattoo | $179,067 | -26.8% | 73 | -31 | $2,452 | $2,342,433 | 4 | Momentum Pictures | false | false |
| 13 | 8 | I Love You Phillip Morris | $171,480 | -68.9% | 131 | -198 | $1,309 | $3,496,127 | 3 | Entertainment One | false | false |
| 14 | 10 | Avatar | $163,709 | -51.1% | 48 | -122 | $3,410 | $138,954,305 | 16 | 20th Century Fox International | false | false |
| 15 | 9 | Shank | $104,782 | -74.8% | 75 | -11 | $1,397 | $713,697 | 2 | Revolver Entertainment | false | false |
