| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 2 | How to Train Your Dragon | $3,312,800 | +45.3% | 361 | -7 | $9,176 | $12,593,237 | 3 | Paramount Pictures International | false | false |
| 2 | 1 | Clash of the Titans | $3,018,410 | -48.8% | 349 | -2 | $8,648 | $12,424,898 | 2 | Warner Bros. | false | false |
| 3 | - | Date Night | $2,003,035 | - | 304 | - | $6,588 | $2,003,035 | 1 | 20th Century Fox International | true | false |
| 4 | 6 | Nanny McPhee Returns | $1,655,798 | +78.7% | 258 | -3 | $6,417 | $4,827,987 | 2 | Universal Pictures International (UPI) | false | false |
| 5 | - | Kick-Ass | $1,536,554 | - | 236 | - | $6,510 | $1,660,195 | 1 | Universal Pictures International (UPI) | true | false |
| 6 | 4 | The Last Song | $1,365,952 | +6.2% | 234 | - | $5,837 | $3,958,414 | 2 | Walt Disney Pictures | false | false |
| 7 | 3 | Alice in Wonderland | $1,200,567 | -16.2% | 376 | - | $3,192 | $32,460,405 | 6 | Walt Disney Pictures | false | false |
| 8 | 5 | She's Out of My League | $553,236 | -41.8% | 185 | +3 | $2,990 | $2,240,118 | 2 | Paramount Pictures International | false | false |
| 9 | 11 | The Spy Next Door 2010 Re-release | $424,407 | +51.5% | 139 | +1 | $3,053 | $1,393,730 | 3 | Roadshow Films | false | false |
| 10 | 9 | The Girl with the Dragon Tattoo | $391,264 | -21.1% | 55 | - | $7,113 | $2,162,555 | 3 | Rialto Distribution | false | false |
| 11 | 7 | The Blind Side | $363,490 | -41.5% | 167 | -42 | $2,176 | $11,677,690 | 7 | Roadshow Films | false | false |
| 12 | 8 | The Bounty Hunter | $226,557 | -55.8% | 164 | -37 | $1,381 | $4,293,114 | 4 | Sony Pictures Releasing | false | false |
| 13 | 12 | Avatar | $184,042 | -32.5% | 56 | -12 | $3,286 | $105,542,357 | 17 | 20th Century Fox International | false | false |
| 14 | 13 | The Last Station 2010 Re-release | $171,792 | -11.4% | 26 | - | $6,607 | $570,160 | 2 | Becker Film Group | false | false |
| 15 | 17 | The Hurt Locker | $167,153 | +101.8% | 71 | -1 | $2,354 | $4,944,089 | 8 | Roadshow Films | false | false |
| 16 | 10 | Green Zone | $154,737 | -65.6% | 91 | -103 | $1,700 | $5,969,528 | 5 | Universal Pictures International (UPI) | false | false |
| 17 | 14 | Micmacs | $121,226 | -8.3% | 27 | - | $4,489 | $475,219 | 2 | Hopscotch Films | false | false |
| 18 | 18 | Welcome | $82,460 | +7% | 19 | +2 | $4,340 | $290,217 | 2 | Palace Films | false | false |
| 19 | 19 | A Single Man | $54,927 | -28% | 27 | -3 | $2,034 | $1,380,617 | 7 | Icon Film Distribution | false | false |
| 20 | 16 | Shutter Island | $40,275 | -63% | 35 | -27 | $1,150 | $9,515,631 | 8 | Paramount Pictures International | false | false |
