| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Alice in Wonderland | $310,653 | -54.3% | 155 | +24 | $2,004 | $7,399,485 | 6 | Walt Disney Pictures | false | false |
| 2 | - | Brother and Sister | $302,417 | - | 62 | - | $4,877 | $908,536 | 2 | Primer Plano Film Group | false | false |
| 3 | 2 | How to Train Your Dragon | $212,999 | -60.6% | 125 | -2 | $1,703 | $1,318,261 | 3 | Paramount Pictures International | false | false |
| 4 | - | Date Night | $133,514 | - | 45 | - | $2,966 | $133,514 | 1 | 20th Century Fox International | true | false |
| 5 | 3 | Shutter Island | $109,166 | -47.3% | 43 | -2 | $2,538 | $1,312,438 | 5 | Paramount Pictures International | false | false |
| 6 | - | Case 39 | $88,424 | - | 32 | - | $2,763 | $88,424 | 1 | Paramount Pictures International | true | false |
| 7 | - | Remember Me | $85,150 | - | 29 | - | $2,936 | $85,150 | 1 | Alfa Films | true | false |
| 8 | 4 | The Bounty Hunter | $74,157 | -58.1% | 43 | - | $1,724 | $274,197 | 2 | Sony Pictures Releasing | false | false |
| 9 | 5 | The Book of Eli | $48,289 | -53.6% | 40 | -1 | $1,207 | $539,706 | 4 | Sony Pictures Releasing | false | false |
| 10 | 6 | The Fourth Kind | $30,642 | -61.1% | 25 | - | $1,225 | $124,667 | 2 | Alfa Films | false | false |
| 11 | - | Remembering the Children | $25,792 | - | 10 | - | $2,579 | $25,792 | 1 | Distribution Company | true | false |
| 12 | 7 | Edge of Darkness | $24,896 | -55.6% | 47 | -9 | $529 | $1,119,990 | 7 | Warner Bros. | false | false |
| 13 | 8 | The Blind Side | $24,024 | -48% | 30 | -3 | $800 | $250,676 | 4 | Warner Bros. | false | false |
| 14 | 11 | Seraphine | $16,224 | -46.9% | 9 | +1 | $1,802 | $52,643 | 2 | N/A | false | false |
| 15 | 14 | Avatar | $13,263 | -33.8% | 10 | - | $1,326 | $13,391,353 | 15 | 20th Century Fox International | false | false |
| 16 | 10 | Brothers | $11,672 | -62.7% | 31 | -3 | $376 | $125,897 | 3 | Distribution Company | false | false |
| 17 | 18 | Couples Retreat | $9,500 | +37.2% | 11 | -2 | $863 | $153,515 | 6 | Universal Pictures International (UPI) | false | false |
| 18 | 12 | The Hurt Locker | $7,264 | -68.2% | 21 | -22 | $345 | $788,741 | 10 | Distribution Company | false | false |
| 19 | 23 | Precious | $6,712 | +49.6% | 11 | +1 | $610 | $291,408 | 9 | N/A | false | false |
| 20 | 15 | Everybody's Fine | $6,261 | -68.6% | 12 | -10 | $521 | $168,840 | 4 | Walt Disney Pictures | false | false |
| 21 | 29 | Crazy Heart | $5,946 | +232% | 10 | +2 | $594 | $101,069 | 5 | 20th Century Fox International | false | false |
| 22 | 16 | Paco | $5,934 | -69.6% | 7 | -13 | $847 | $174,415 | 4 | Primer Plano Film Group | false | false |
| 23 | 17 | Did You Hear About the Morgans? | $5,304 | -65.9% | 14 | -11 | $378 | $278,549 | 5 | Sony Pictures Releasing | false | false |
| 24 | 9 | Fame | $4,718 | -89.3% | 18 | -19 | $262 | $54,367 | 2 | Impacto Cine | false | false |
| 25 | 13 | The Rebound | $4,436 | -79.8% | 12 | -16 | $369 | $98,751 | 3 | Alfa Films | false | false |
| 26 | 19 | The Girl with the Dragon Tattoo | $3,164 | -54.1% | 5 | -9 | $632 | $275,597 | 8 | N/A | false | false |
| 27 | 34 | Old Dogs | $2,549 | +133.6% | 9 | +3 | $283 | $1,507,717 | 12 | Walt Disney Pictures | false | false |
| 28 | 21 | The Wolfman | $2,146 | -57.4% | 7 | -5 | $306 | $1,119,295 | 9 | Universal Pictures International (UPI) | false | false |
| 29 | 24 | A Serious Man | $1,788 | -46.8% | 8 | +5 | $223 | $147,244 | 7 | Universal Pictures International (UPI) | false | false |
| 30 | 20 | Bad Lieutenant: Port of Call New Orleans | $1,552 | -74.8% | 6 | -9 | $258 | $170,195 | 6 | Distribution Company | false | false |
| 31 | 31 | Our Beloved Month of August | $1,166 | -27.1% | 4 | +1 | $291 | $38,886 | 6 | N/A | false | false |
| 32 | 40 | Up in the Air | $1,052 | +87.5% | 2 | - | $526 | $722,249 | 12 | Paramount Pictures International | false | false |
| 33 | 33 | The Princess and the Frog | $1,039 | -22.5% | 4 | -4 | $259 | $1,921,146 | 14 | Walt Disney Pictures | false | false |
| 34 | 27 | Valentine's Day | $1,035 | -60.4% | 3 | -8 | $345 | $883,764 | 9 | Warner Bros. | false | false |
| 35 | 22 | The Secret in Their Eyes | $1,023 | -78.1% | 7 | -9 | $146 | $9,253,698 | 35 | Distribution Company | false | false |
| 36 | 35 | Tooth Fairy | $1,003 | +43.1% | 4 | +1 | $250 | $482,136 | 10 | 20th Century Fox International | false | false |
| 37 | 25 | Percy Jackson & the Olympians: The Lightning Thief | $825 | -72.7% | 7 | -8 | $117 | $722,825 | 8 | 20th Century Fox International | false | false |
| 38 | 32 | Birds of Paradise | $658 | -57.8% | 3 | -2 | $219 | $192,485 | 8 | Sony Pictures Releasing | false | false |
| 39 | 46 | Nine | $605 | +1,020.4% | 2 | +1 | $302 | $268,101 | 11 | Sony Pictures Releasing | false | false |
| 40 | 28 | Invictus | $375 | -81% | 2 | -4 | $187 | $981,517 | 11 | Warner Bros. | false | false |
| 41 | 26 | 9 | $304 | -88.8% | 2 | -12 | $152 | $36,144 | 4 | Distribution Company | false | false |
| 42 | 37 | Zombieland | $302 | -56% | 2 | - | $151 | $107,474 | 11 | Sony Pictures Releasing | false | false |
| 43 | 38 | Alvin and the Chipmunks: The Squeakquel | $222 | -67% | 2 | -2 | $111 | $1,088,298 | 12 | 20th Century Fox International | false | false |
| 44 | 41 | Mongol: The Rise of Genghis Khan | $113 | -79.7% | 1 | - | $113 | $9,398 | 5 | Alfa Films | false | false |
| 45 | 42 | Coco 2010 Re-release | $46 | -84.5% | 1 | -1 | $46 | $13,630 | 3 | Impacto Cine | false | false |
| 46 | 39 | Astro Boy | $35 | -94.6% | 1 | -9 | $35 | $174,339 | 11 | Alfa Films | false | false |
