| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Alice in Wonderland | $1,084,218 | +2.4% | 167 | -5 | $6,492 | $7,178,791 | 4 | Walt Disney Pictures | false | false |
| 2 | - | How to Train Your Dragon | $711,236 | - | 173 | - | $4,111 | $877,762 | 1 | Universal Pictures International (UPI) | true | false |
| 3 | - | The Bounty Hunter | $449,648 | - | 51 | - | $8,816 | $449,648 | 1 | Sony Pictures Releasing | true | false |
| 4 | 5 | Nanny McPhee Returns | $239,862 | +27.7% | 99 | - | $2,422 | $497,256 | 2 | Universal Pictures International (UPI) | false | false |
| 5 | 2 | Dear John | $238,340 | -10.3% | 81 | - | $2,942 | $1,563,240 | 4 | A-Film Distribution | false | false |
| 6 | - | Remember Me | $225,272 | - | 66 | - | $3,413 | $276,832 | 1 | Independent Films | true | false |
| 7 | 3 | Avatar | $183,679 | -9.7% | 54 | +3 | $3,401 | $24,783,366 | 16 | 20th Century Fox International | false | false |
| 8 | 4 | From Paris with Love | $169,516 | -10.5% | 69 | -1 | $2,456 | $774,389 | 3 | Entertainment One | false | false |
| 9 | 7 | Shutter Island | $148,357 | +11.3% | 51 | - | $2,908 | $2,424,332 | 7 | Universal Pictures International (UPI) | false | false |
| 10 | 6 | The Girl Who Kicked the Hornet's Nest | $142,707 | +2.1% | 40 | - | $3,567 | $360,284 | 2 | Benelux Film Distributors | false | false |
| 11 | 9 | First Mission | $67,806 | -9.1% | 58 | -1 | $1,169 | $176,915 | 2 | A-Film Distribution | false | false |
| 12 | 8 | The Book of Eli | $64,409 | -24.4% | 39 | -16 | $1,651 | $962,952 | 5 | Paradiso Entertainment | false | false |
| 13 | 13 | Eep! 2010 Re-release | $55,723 | +35.8% | 90 | - | $619 | $1,659,938 | 7 | Independent Films | false | false |
| 14 | 10 | Solomon Kane | $50,624 | -29.7% | 20 | - | $2,531 | $175,286 | 2 | Entertainment One | false | false |
| 15 | - | Nowhere Boy | $46,280 | - | 13 | - | $3,560 | $55,662 | 1 | A-Film Distribution | true | false |
| 16 | 15 | The Princess and the Frog | $44,842 | +27.6% | 95 | -7 | $472 | $3,013,090 | 9 | Walt Disney Pictures | false | false |
| 17 | 14 | Gangsterboys | $43,737 | +13.9% | 30 | -3 | $1,457 | $1,441,099 | 7 | Independent Films | false | false |
| 18 | 11 | Cloudy with a Chance of Meatballs | $43,610 | -16.5% | 55 | -9 | $792 | $2,447,098 | 7 | Sony Pictures Releasing | false | false |
| 19 | 12 | Case 39 | $39,635 | -13.8% | 19 | - | $2,086 | $190,367 | 3 | Universal Pictures International (UPI) | false | false |
| 20 | 16 | Invictus | $33,154 | -5.2% | 21 | -4 | $1,578 | $411,567 | 5 | Warner Bros. | false | false |
