| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | The Bounty Hunter | $35,411 | -28% | 7 | - | $5,058 | $104,497 | 2 | Sony Pictures Releasing | false | false |
| 2 | 2 | Alice in Wonderland | $29,358 | -27% | 6 | - | $4,893 | $349,122 | 5 | Walt Disney Pictures | false | false |
| 3 | 3 | How to Train Your Dragon | $21,578 | -22.9% | 7 | - | $3,082 | $56,874 | 2 | United International Pictures | false | false |
| 4 | - | Remember Me | $18,123 | - | 6 | - | $3,020 | $18,123 | 1 | Jaguar Film International Distribution | true | false |
| 5 | 4 | Green Zone | $16,650 | -25.4% | 8 | - | $2,081 | $110,283 | 3 | United International Pictures | false | false |
| 6 | - | The Last Song | $15,982 | - | 5 | - | $3,196 | $15,982 | 1 | Walt Disney Pictures | true | false |
| 7 | 5 | Shutter Island | $13,780 | -23% | 5 | - | $2,756 | $134,796 | 4 | United International Pictures | false | false |
| 8 | - | Tooth Fairy | $13,722 | - | 6 | - | $2,287 | $13,722 | 1 | 20th Century Fox International | true | false |
| 9 | - | Dorian Gray | $9,751 | - | 1 | - | $9,751 | $9,751 | 1 | Prime Pictures | true | false |
| 10 | 6 | Dear John | $6,245 | -58.3% | 3 | - | $2,081 | $26,747 | 2 | N/A | false | false |
| 11 | 8 | Avatar | $5,131 | -43.2% | 2 | - | $2,565 | $1,679,808 | 16 | 20th Century Fox International | false | false |
| 12 | 10 | The Spy Next Door 2010 Re-release | $4,179 | -26.3% | 2 | - | $2,089 | $40,916 | 4 | N/A | false | false |
| 13 | 7 | My Name Is Khan | $4,075 | -57.3% | 3 | -3 | $1,358 | $45,092 | 4 | 20th Century Fox International | false | false |
| 14 | - | Arthur and the Revenge of Maltazard | $3,826 | - | 6 | - | $637 | $3,826 | 1 | Walt Disney Pictures | true | false |
| 15 | - | Carriers | $3,444 | - | 3 | - | $1,148 | $3,444 | 1 | N/A | true | false |
| 16 | 9 | When in Rome | $3,183 | -57% | 5 | -1 | $636 | $102,877 | 6 | Walt Disney Pictures | false | false |
| 17 | 11 | From Paris with Love | $1,157 | -78.8% | 3 | -2 | $385 | $172,197 | 7 | Italian International Film | false | false |
| 18 | 17 | The Wolfman | $1,121 | +31% | 1 | - | $1,121 | $115,714 | 7 | United International Pictures | false | false |
| 19 | 12 | Universal Soldier: Regeneration | $800 | -84.6% | 1 | -4 | $800 | $7,455 | 2 | - | false | false |
| 20 | 15 | Agora | $622 | -34.4% | 2 | - | $311 | $131,500 | 14 | Italian International Film | false | false |
| 21 | 13 | The Burning Plain | $558 | -85.7% | 2 | -2 | $279 | $13,631 | 3 | N/A | false | false |
| 22 | 18 | Edge of Darkness | $500 | -28.8% | 1 | - | $500 | $112,285 | 9 | N/A | false | false |
| 23 | 23 | In the Loop | $293 | +7.3% | 1 | - | $293 | $2,619 | 5 | N/A | false | false |
| 24 | 14 | Percy Jackson & the Olympians: The Lightning Thief | $162 | -88.5% | 1 | -1 | $162 | $84,323 | 6 | 20th Century Fox International | false | false |
| 25 | 16 | Siraj El Wadi | $140 | -84.5% | 1 | -1 | $140 | $72,220 | 22 | Italian International Film | false | false |
| 26 | 22 | Old Dogs | $127 | -59.2% | 1 | - | $127 | $171,410 | 19 | Walt Disney Pictures | false | false |
| 27 | 25 | The Last Flight | $96 | -8.6% | 1 | - | $96 | $5,150 | 5 | N/A | false | false |
| 28 | - | Up in the Air | $13 | - | 1 | - | $13 | $85,880 | 11 | United International Pictures | false | false |
