| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Clash of the Titans | $5,892,857 | - | 351 | - | $16,788 | $5,892,857 | 1 | Warner Bros. | true | false |
| 2 | 1 | How to Train Your Dragon | $2,279,992 | -37.8% | 368 | +1 | $6,195 | $6,016,257 | 2 | Paramount Pictures International | false | false |
| 3 | 2 | Alice in Wonderland | $1,432,850 | -50.8% | 376 | -17 | $3,810 | $29,423,666 | 5 | Walt Disney Pictures | false | false |
| 4 | - | The Last Song | $1,286,400 | - | 234 | - | $5,497 | $1,286,400 | 1 | Walt Disney Pictures | true | false |
| 5 | - | She's Out of My League | $949,853 | - | 182 | - | $5,218 | $970,292 | 1 | Paramount Pictures International | true | false |
| 6 | - | Nanny McPhee Returns | $926,574 | - | 261 | - | $3,550 | $1,545,443 | 1 | Universal Pictures International (UPI) | true | false |
| 7 | 4 | The Blind Side | $621,616 | -42.6% | 209 | -10 | $2,974 | $10,703,803 | 6 | Roadshow Films | false | false |
| 8 | 3 | The Bounty Hunter | $512,281 | -62.6% | 201 | -3 | $2,548 | $3,614,135 | 3 | Sony Pictures Releasing | false | false |
| 9 | 6 | The Girl with the Dragon Tattoo | $496,131 | -28.9% | 55 | +2 | $9,020 | $1,442,484 | 2 | Rialto Distribution | false | false |
| 10 | 5 | Green Zone | $449,322 | -57.8% | 194 | -49 | $2,316 | $5,455,592 | 4 | Universal Pictures International (UPI) | false | false |
| 11 | 15 | The Spy Next Door 2010 Re-release | $280,077 | +31.2% | 138 | +104 | $2,029 | $500,414 | 2 | Roadshow Films | false | false |
| 12 | 10 | Avatar | $272,836 | -38.1% | 68 | -25 | $4,012 | $103,612,478 | 16 | 20th Century Fox International | false | false |
| 13 | - | The Last Station 2010 Re-release | $193,966 | - | 26 | - | $7,460 | $258,475 | 1 | Becker Film Group | true | false |
| 14 | - | Micmacs | $132,229 | - | 27 | - | $4,897 | $156,788 | 1 | Hopscotch Films | true | false |
| 15 | 8 | Cop Out | $115,078 | -78.6% | 349 | +204 | $329 | $1,455,162 | 3 | Warner Bros. | false | false |
| 16 | 13 | Shutter Island | $108,840 | -63.8% | 62 | -47 | $1,755 | $9,260,524 | 7 | Paramount Pictures International | false | false |
| 17 | 9 | The Hurt Locker | $82,820 | -84% | 72 | -4 | $1,150 | $4,330,268 | 7 | Roadshow Films | false | false |
| 18 | - | Welcome | $77,057 | - | 17 | - | $4,532 | $157,119 | 1 | Palace Films | true | false |
| 19 | 17 | A Single Man | $76,239 | -41.4% | 30 | +2 | $2,541 | $1,255,433 | 6 | Icon Film Distribution | false | false |
| 20 | 11 | Dear John | $71,043 | -80.7% | 67 | -83 | $1,060 | $4,164,640 | 5 | Roadshow Films | false | false |
