| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 2 | How to Train Your Dragon | $380,628 | +110.4% | 91 | +70 | $4,182 | $615,571 | 2 | United International Pictures | false | false |
| 2 | 1 | Alice in Wonderland | $246,251 | -39.9% | 97 | +4 | $2,538 | $2,835,618 | 4 | Walt Disney Pictures | false | false |
| 3 | 3 | The Book of Eli | $118,421 | -33.3% | 30 | - | $3,947 | $336,197 | 2 | Sony Pictures Releasing | false | false |
| 4 | 4 | Miss You Like Crazy | $59,807 | -51.7% | 30 | -15 | $1,993 | $3,087,282 | 5 | Star Cinema | false | false |
| 5 | 6 | Green Zone | $44,998 | -47.4% | 31 | +6 | $1,451 | $290,859 | 3 | United International Pictures | false | false |
| 6 | - | I Love You Phillip Morris | $41,093 | - | 14 | - | $2,935 | $41,093 | 1 | Pioneer Films | true | false |
| 7 | 7 | Remember Me | $28,537 | -40% | 30 | -15 | $951 | $191,413 | 3 | Pioneer Films | false | false |
| 8 | 5 | When in Rome | $28,108 | -71.4% | 22 | -28 | $1,277 | $154,090 | 2 | Walt Disney Pictures | false | false |
| 9 | 8 | Percy Jackson & the Olympians: The Lightning Thief | $11,622 | -49% | 11 | -5 | $1,056 | $2,010,604 | 7 | 20th Century Fox International | false | false |
| 10 | 9 | Cop Out | $9,183 | -45.1% | 14 | -13 | $655 | $248,909 | 4 | Warner Bros. | false | false |
| 11 | 12 | Invictus | $7,595 | +45.6% | 16 | +5 | $474 | $72,590 | 6 | Warner Bros. | false | false |
| 12 | 13 | From Paris with Love | $6,072 | +53.8% | 15 | -3 | $404 | $196,856 | 5 | Viva International Pictures | false | false |
| 13 | 11 | Extraordinary Measures | $5,496 | -49.7% | 5 | -14 | $1,099 | $106,558 | 3 | Sony Pictures Releasing | false | false |
| 14 | 18 | It's Complicated | $3,717 | +276.6% | 5 | +3 | $743 | $84,765 | 5 | United International Pictures | false | false |
| 15 | 10 | The Fourth Kind | $2,862 | -77.9% | 9 | -6 | $318 | $103,329 | 4 | Viva International Pictures | false | false |
| 16 | 14 | The Wolfman | $1,970 | -44.1% | 2 | -1 | $985 | $583,222 | 7 | United International Pictures | false | false |
| 17 | 16 | Up in the Air | $1,321 | -43.9% | 4 | - | $330 | $79,421 | 4 | United International Pictures | false | false |
| 18 | 21 | Valentine's Day | $1,132 | +546.9% | 2 | +1 | $566 | $736,596 | 7 | Warner Bros. | false | false |
