| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | How to Train Your Dragon | $378,368 | - | 59 | - | $6,413 | $378,368 | 1 | Paramount Pictures International | true | false |
| 2 | 1 | Alice in Wonderland | $105,086 | -63.1% | 53 | - | $1,982 | $1,541,996 | 4 | Walt Disney Pictures | false | false |
| 3 | - | The Blind Side | $95,588 | - | 18 | - | $5,310 | $108,640 | 1 | Warner Bros. | true | false |
| 4 | 2 | Shutter Island | $58,958 | -44.9% | 32 | - | $1,842 | $458,402 | 3 | Paramount Pictures International | false | false |
| 5 | 3 | My Best Friend's Girl | $54,193 | -34.2% | 27 | - | $2,007 | $171,397 | 2 | N/A | false | false |
| 6 | - | Eden Lake | $41,482 | - | 16 | - | $2,592 | $41,482 | 1 | N/A | true | false |
| 7 | 4 | Did You Hear About the Morgans? | $25,206 | -49.7% | 21 | -1 | $1,200 | $95,281 | 2 | Sony Pictures Releasing | false | false |
| 8 | 5 | An American Crime | $21,865 | -47.9% | 14 | - | $1,561 | $81,613 | 2 | N/A | false | false |
| 9 | 11 | Edge of Darkness | $21,053 | +78.7% | 28 | - | $751 | $373,875 | 5 | Warner Bros. | false | false |
| 10 | - | When in Rome | $18,816 | - | 10 | - | $1,881 | $18,816 | 1 | Walt Disney Pictures | true | false |
| 11 | 6 | The Hurt Locker | $16,821 | -57.5% | 15 | - | $1,121 | $311,450 | 6 | N/A | false | false |
| 12 | 12 | Saw VI | $6,184 | -45.7% | 25 | - | $247 | $206,340 | 6 | Walt Disney Pictures | false | false |
| 13 | 7 | All About Steve | $4,561 | -79.9% | 21 | - | $217 | $113,615 | 3 | 20th Century Fox International | false | false |
| 14 | 25 | The Stepfather | $2,883 | -2.3% | 3 | +1 | $961 | $121,738 | 11 | Sony Pictures Releasing | false | false |
| 15 | 16 | Armored | $2,563 | -58% | 4 | -1 | $640 | $111,482 | 8 | Sony Pictures Releasing | false | false |
| 16 | 29 | Nine | $2,481 | +43.2% | 2 | -2 | $1,240 | $67,971 | 5 | Sony Pictures Releasing | false | false |
| 17 | 13 | Extraordinary Measures | $2,401 | -74.6% | 2 | -9 | $1,200 | $52,900 | 3 | Sony Pictures Releasing | false | false |
| 18 | - | 9 | $2,010 | - | 20 | - | $100 | $66,419 | 6 | N/A | false | false |
| 19 | 9 | Percy Jackson & the Olympians: The Lightning Thief | $1,727 | -87.3% | 43 | - | $40 | $961,013 | 7 | 20th Century Fox International | false | false |
| 20 | - | Diary of a Nymphomaniac | $1,716 | - | 10 | - | $171 | $80,255 | 29 | N/A | false | false |
| 21 | 19 | Old Dogs | $1,598 | -68.8% | 42 | - | $38 | $1,158,485 | 9 | Walt Disney Pictures | false | false |
| 22 | 23 | The Imaginarium of Doctor Parnassus | $1,513 | -58.8% | 3 | -1 | $504 | $111,406 | 9 | Sony Pictures Releasing | false | false |
| 23 | - | Splinter | $1,493 | - | 10 | - | $149 | $68,900 | 9 | N/A | false | false |
| 24 | 21 | The Code | $1,037 | -75.1% | 19 | - | $54 | $109,350 | 11 | N/A | false | false |
| 25 | 15 | All the Boys Love Mandy Lane | $833 | -87.3% | 14 | - | $59 | $133,286 | 8 | N/A | false | false |
| 26 | 24 | Bonneville | $831 | -74.3% | 3 | - | $277 | $5,546 | 2 | N/A | false | false |
| 27 | 8 | Personal Effects | $725 | -95.1% | 10 | - | $72 | $22,362 | 2 | N/A | false | false |
| 28 | 17 | Precious | $539 | -90.8% | 7 | - | $77 | $98,980 | 5 | N/A | false | false |
| 29 | 28 | The Wolfman | $418 | -81.9% | 48 | - | $8 | $978,807 | 7 | Universal Pictures International (UPI) | false | false |
| 30 | 36 | Right at Your Door 2009 Re-release | $413 | -28.3% | 1 | - | $413 | $16,444 | 23 | N/A | false | false |
| 31 | 20 | Everybody's Fine | $391 | -90.9% | 11 | - | $35 | $34,806 | 3 | Walt Disney Pictures | false | false |
| 32 | 31 | Broken Embraces | $384 | -71.4% | 15 | - | $25 | $44,761 | 4 | Universal Pictures International (UPI) | false | false |
| 33 | 26 | The True Story of Puss'N Boots | $353 | -85.6% | 20 | - | $17 | $113,229 | 5 | N/A | false | false |
| 34 | 18 | Up in the Air | $124 | -97.6% | 14 | - | $8 | $236,327 | 10 | Paramount Pictures International | false | false |
| 35 | 33 | Tooth Fairy | $92 | -90.9% | 36 | - | $2 | $909,201 | 11 | 20th Century Fox International | false | false |
