| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Alice in Wonderland | $3,601,387 | -39.2% | 444 | -4 | $8,111 | $23,896,482 | 3 | Walt Disney Pictures | false | false |
| 2 | - | The Bounty Hunter | $1,264,448 | - | 204 | - | $6,198 | $1,264,448 | 1 | Sony Pictures Releasing | true | false |
| 3 | 2 | Green Zone | $1,133,620 | -37.4% | 245 | - | $4,627 | $3,528,669 | 2 | Universal Pictures International (UPI) | false | false |
| 4 | 3 | The Blind Side | $927,160 | -29% | 226 | +20 | $4,102 | $8,599,514 | 4 | Roadshow Films | false | false |
| 5 | - | Cop Out | $581,031 | - | 146 | - | $3,979 | $581,031 | 1 | Warner Bros. | true | false |
| 6 | 5 | The Hurt Locker | $528,006 | -28.7% | 74 | +3 | $7,135 | $3,517,770 | 5 | Roadshow Films | false | false |
| 7 | 6 | Avatar | $514,767 | -28% | 139 | -26 | $3,703 | $102,293,852 | 14 | 20th Century Fox International | false | false |
| 8 | 4 | Dear John | $393,973 | -52.1% | 194 | +5 | $2,030 | $3,560,742 | 3 | Roadshow Films | false | false |
| 9 | - | The Rebound | $381,100 | - | 189 | - | $2,016 | $381,100 | 1 | Roadshow Films | true | false |
| 10 | 7 | Shutter Island | $308,585 | -49.6% | 154 | -74 | $2,003 | $8,687,901 | 5 | Paramount Pictures International | false | false |
| 11 | 8 | Remember Me | $248,961 | -46.8% | 174 | +1 | $1,430 | $916,320 | 2 | Hoyts Distribution | false | false |
| 12 | - | The Girl with the Dragon Tattoo | $233,547 | - | 44 | - | $5,307 | $233,547 | - | Rialto Distribution | - | false |
| 13 | 9 | The Men Who Stare at Goats | $154,477 | -37.3% | 58 | - | $2,663 | $1,145,796 | 3 | Sony Pictures Releasing | false | false |
| 14 | 11 | A Single Man | $113,883 | -18.6% | 28 | +1 | $4,067 | $995,483 | 4 | Icon Film Distribution | false | false |
| 15 | - | Brothers | $85,145 | - | 22 | - | $3,870 | $85,145 | 1 | Roadshow Films | true | false |
| 16 | 13 | Crazy Heart | $57,023 | -44.3% | 55 | -17 | $1,036 | $873,124 | 5 | 20th Century Fox International | false | false |
| 17 | 10 | Valentine's Day | $46,172 | -75.8% | 69 | -117 | $669 | $14,478,430 | 6 | Warner Bros. | false | false |
| 18 | 15 | Precious | $37,504 | -43.8% | 39 | -11 | $961 | $1,155,929 | 7 | Icon Film Distribution | false | false |
| 19 | 16 | Up in the Air | $36,267 | -39.3% | 50 | -14 | $725 | $7,481,902 | 10 | Paramount Pictures International | false | false |
| 20 | 12 | Percy Jackson & the Olympians: The Lightning Thief | $35,779 | -71.6% | 64 | -79 | $559 | $4,567,200 | 6 | 20th Century Fox International | false | false |
| 21 | 18 | My One and Only | $27,846 | -36.1% | 24 | +4 | $1,160 | $98,419 | 2 | Hopscotch Films | false | false |
| 22 | 21 | Cirque du Freak: The Vampire's Assistant | $12,052 | -66.6% | 25 | -16 | $482 | $59,271 | 2 | Universal Pictures International (UPI) | false | false |
| 23 | - | Five Minutes of Heaven | $6,192 | - | 5 | - | $1,238 | $6,192 | 1 | Madman Entertainment | true | false |
