| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Alice in Wonderland | $1,124,008 | -15.3% | 129 | -3 | $8,713 | $5,212,850 | 3 | Walt Disney Pictures | false | false |
| 2 | 2 | Shutter Island | $235,243 | -23.9% | 43 | -1 | $5,470 | $626,058 | 2 | Paramount Pictures International | false | false |
| 3 | - | The Book of Eli | $171,519 | - | 41 | - | $4,183 | $171,519 | 1 | Sony Pictures Releasing | true | false |
| 4 | 3 | Edge of Darkness | $87,461 | -34% | 64 | -1 | $1,366 | $923,241 | 4 | Warner Bros. | false | false |
| 5 | - | The Blind Side | $86,016 | - | 30 | - | $2,867 | $86,016 | 1 | Warner Bros. | true | false |
| 6 | 4 | The Hurt Locker | $84,064 | -24.1% | 48 | -1 | $1,751 | $732,152 | 7 | Distribution Company | false | false |
| 7 | - | Everybody's Fine | $69,714 | - | 26 | - | $2,681 | $69,714 | 1 | Walt Disney Pictures | true | false |
| 8 | - | Paco | $64,796 | - | 42 | - | $1,542 | $64,796 | 1 | Primer Plano Film Group | true | false |
| 9 | 6 | Avatar | $48,072 | -43% | 30 | -37 | $1,602 | $13,382,203 | 12 | 20th Century Fox International | false | false |
| 10 | 5 | Did You Hear About the Morgans? | $47,094 | -45% | 30 | - | $1,569 | $206,682 | 2 | Sony Pictures Releasing | false | false |
| 11 | 8 | The Wolfman | $23,535 | -47.9% | 48 | -14 | $490 | $1,093,535 | 6 | Universal Pictures International (UPI) | false | false |
| 12 | 10 | Percy Jackson & the Olympians: The Lightning Thief | $22,374 | -40.2% | 45 | -12 | $497 | $702,486 | 5 | 20th Century Fox International | false | false |
| 13 | 7 | Crazy Heart | $22,048 | -64.2% | 10 | - | $2,204 | $83,633 | 2 | 20th Century Fox International | false | false |
| 14 | 18 | The Girl with the Dragon Tattoo | $18,492 | +106.8% | 23 | +6 | $804 | $240,247 | 5 | N/A | false | false |
| 15 | - | 9 | $18,020 | - | 19 | - | $948 | $18,020 | 1 | Distribution Company | true | false |
| 16 | 11 | Precious | $15,119 | -50% | 14 | -11 | $1,079 | $262,197 | 6 | N/A | false | false |
| 17 | 12 | Invictus | $15,091 | -49.1% | 34 | -7 | $443 | $970,303 | 8 | Warner Bros. | false | false |
| 18 | 9 | The Secret in Their Eyes | $14,094 | -64.3% | 35 | -26 | $402 | $9,275,079 | 32 | Distribution Company | false | false |
| 19 | 19 | A Serious Man | $11,387 | +31.6% | 11 | +4 | $1,035 | $130,657 | 4 | Universal Pictures International (UPI) | false | false |
| 20 | 14 | The Imaginarium of Doctor Parnassus | $10,306 | -61.5% | 6 | -21 | $1,717 | $230,176 | 4 | Sony Pictures Releasing | false | false |
| 21 | 13 | Bad Lieutenant: Port of Call New Orleans | $8,630 | -68.1% | 18 | -15 | $479 | $144,543 | 3 | Distribution Company | false | false |
| 22 | 16 | Valentine's Day | $8,245 | -49.6% | 16 | -15 | $515 | $873,443 | 6 | Warner Bros. | false | false |
| 23 | 17 | Old Dogs | $7,625 | -32.6% | 32 | -8 | $238 | $1,506,774 | 9 | Walt Disney Pictures | false | false |
| 24 | 15 | Couples Retreat | $7,351 | -70.3% | 10 | -13 | $735 | $114,454 | 3 | Universal Pictures International (UPI) | false | false |
| 25 | 20 | Astro Boy | $6,097 | -17.3% | 17 | +1 | $358 | $169,886 | 8 | Alfa Films | false | false |
| 26 | 21 | Our Beloved Month of August | $4,840 | -31.8% | 4 | - | $1,210 | $28,269 | 3 | N/A | false | false |
| 27 | 26 | The Lovely Bones | $3,513 | +4.9% | 5 | -5 | $702 | $208,675 | 5 | Paramount Pictures International | false | false |
| 28 | - | The Last Days of Emma Blank | $3,273 | - | 3 | - | $1,091 | $3,273 | 1 | CDI Films | true | false |
| 29 | 22 | Birds of Paradise | $3,098 | -43.1% | 13 | -6 | $238 | $188,217 | 5 | Sony Pictures Releasing | false | false |
| 30 | 23 | Alvin and the Chipmunks: The Squeakquel | $2,531 | -48.5% | 5 | -9 | $506 | $1,091,415 | 9 | 20th Century Fox International | false | false |
| 31 | 31 | The Princess and the Frog | $2,060 | +7.2% | 10 | +3 | $206 | $1,926,875 | 11 | Walt Disney Pictures | false | false |
| 32 | 33 | Nine | $1,719 | +1.1% | 3 | -1 | $573 | $265,528 | 8 | Sony Pictures Releasing | false | false |
| 33 | 40 | The Young Victoria | $1,709 | +250.9% | 3 | +1 | $569 | $181,293 | 10 | Distribution Company | false | false |
| 34 | 38 | Zombieland | $1,492 | +74.7% | 5 | +4 | $298 | $104,938 | 8 | Sony Pictures Releasing | false | false |
| 35 | 30 | Daybreakers | $1,213 | -43.1% | 4 | - | $303 | $389,106 | 9 | Distribution Company | false | false |
| 36 | 35 | An Education | $1,127 | -29.3% | 6 | +2 | $187 | $184,672 | 7 | Sony Pictures Releasing | false | false |
| 37 | 25 | Mongol: The Rise of Genghis Khan | $1,121 | -70.8% | 3 | -1 | $373 | $6,322 | 2 | Alfa Films | false | false |
| 38 | 24 | Sherlock Holmes | $916 | -78% | 5 | -11 | $183 | $2,701,248 | 10 | Warner Bros. | false | false |
| 39 | 32 | It's Complicated | $861 | -55.1% | 3 | - | $287 | $1,311,574 | 11 | Universal Pictures International (UPI) | false | false |
| 40 | 34 | The Wedding Song | $855 | -48.5% | 2 | -1 | $427 | $35,005 | 5 | Primer Plano Film Group | false | false |
| 41 | 41 | Ninja Assassin | $563 | +59.5% | 2 | - | $281 | $131,003 | 11 | Warner Bros. | false | false |
| 42 | 27 | Up in the Air | $517 | -82.2% | 6 | -6 | $86 | $723,720 | 9 | Paramount Pictures International | false | false |
| 43 | - | Un fueguito. La historia de César Milstein | $460 | - | 1 | - | $460 | $11,515 | 2 | Primer Plano Film Group | false | false |
| 44 | 36 | Nora's Will | $293 | -67.9% | 1 | -1 | $293 | $53,668 | 8 | Primer Plano Film Group | false | false |
| 45 | 43 | Andres Doesn't Want to Take a Nap | $171 | -32.1% | 2 | -1 | $85 | $14,512 | 7 | Primer Plano Film Group | false | false |
| 46 | 29 | Tooth Fairy | $50 | -97.9% | 1 | -10 | $50 | $482,385 | 7 | 20th Century Fox International | false | false |
| 47 | 44 | Let it Rain | $26 | -86.5% | 1 | - | $26 | $140,082 | 15 | Alfa Films | false | false |
| 48 | 28 | Inglourious Basterds | $10 | -99.7% | 1 | -1 | $10 | $1,222,549 | 29 | Universal Pictures International (UPI) | false | false |
| 49 | 46 | Broken Embraces | $5 | -96.2% | 1 | - | $5 | $518,333 | 25 | Universal Pictures International (UPI) | false | false |
