| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Alice in Wonderland | $33,988 | -12.2% | 6 | - | $5,664 | $101,201 | 2 | Walt Disney Pictures | false | false |
| 2 | - | Shutter Island | $22,963 | - | 4 | - | $5,740 | $49,775 | 1 | United International Pictures | true | false |
| 3 | 2 | Avatar | $13,678 | -48.4% | 14 | - | $977 | $1,257,244 | 13 | 20th Century Fox International | false | false |
| 4 | 3 | The Wolfman | $7,909 | -36.1% | 6 | - | $1,318 | $57,291 | 3 | United International Pictures | false | false |
| 5 | - | The Men Who Stare at Goats | $5,999 | - | 4 | - | $1,499 | $12,685 | 1 | N/A | true | false |
| 6 | 4 | Percy Jackson & the Olympians: The Lightning Thief | $5,671 | -36.5% | 7 | - | $810 | $33,166 | 3 | 20th Century Fox International | false | false |
| 7 | 5 | Valentine's Day | $4,358 | -41.5% | 6 | - | $726 | $121,919 | 5 | Warner Bros. | false | false |
| 8 | 8 | The Princess and the Frog | $2,304 | -4.8% | 6 | - | $384 | $62,491 | 7 | Walt Disney Pictures | false | false |
| 9 | 6 | Invictus 2010 Re-release | $2,291 | -48.8% | 4 | - | $572 | $23,189 | 2 | Warner Bros. | false | false |
| 10 | 10 | Toy Story 2009 Re-release | $2,169 | -4.4% | 3 | - | $723 | $28,157 | 5 | Walt Disney Pictures | false | false |
| 11 | 12 | Alvin and the Chipmunks: The Squeakquel | $2,068 | +30.8% | 6 | - | $344 | $56,916 | 9 | 20th Century Fox International | false | false |
| 12 | 9 | The Imaginarium of Doctor Parnassus | $1,858 | -20.3% | 2 | - | $929 | $32,075 | 5 | N/A | false | false |
| 13 | 11 | Sherlock Holmes | $1,635 | -24.2% | 6 | - | $272 | $220,956 | 10 | Warner Bros. | false | false |
| 14 | - | Daybreakers | $1,227 | - | 2 | - | $613 | $1,423 | 1 | N/A | true | false |
| 15 | 7 | The Lovely Bones | $1,064 | -59.3% | 5 | - | $212 | $26,356 | 4 | United International Pictures | false | false |
| 16 | 15 | Nine | $1,001 | -19% | 4 | - | $250 | $30,275 | 6 | N/A | false | false |
| 17 | 16 | Arthur and the Revenge of Maltazard | $892 | -20.9% | 6 | - | $148 | $61,151 | 11 | N/A | false | false |
| 18 | 18 | Did You Hear About the Morgans? | $743 | +1.5% | 4 | -2 | $185 | $86,137 | 8 | Sony Pictures Releasing | false | false |
| 19 | 13 | Law Abiding Citizen | $621 | -54.1% | 5 | - | $124 | $20,469 | 4 | N/A | false | false |
| 20 | 14 | Pope Joan | $465 | -64% | 2 | - | $232 | $8,410 | 2 | N/A | false | false |
| 21 | 17 | Antichrist | $441 | -40.6% | 1 | - | $441 | $11,843 | 2 | N/A | false | false |
| 22 | 20 | The White Ribbon | $407 | +4.1% | 1 | - | $407 | $12,940 | 4 | N/A | false | false |
| 23 | - | Baaria | $333 | - | 1 | - | $333 | $14,027 | 1 | N/A | true | false |
| 24 | 21 | The Flight Before Christmas | $288 | -21.5% | 3 | - | $96 | $13,099 | 14 | N/A | false | false |
| 25 | 22 | Garfield's Fun Fest | $287 | -1% | 2 | - | $143 | $13,659 | 12 | N/A | false | false |
| 26 | 24 | It's Complicated | $262 | +33.7% | 9 | - | $29 | $114,556 | 12 | United International Pictures | false | false |
| 27 | 23 | Up in the Air | $247 | -1.6% | 5 | - | $49 | $44,838 | 6 | United International Pictures | false | false |
| 28 | 19 | Don't Look Back | $235 | -55.2% | 2 | - | $117 | $12,867 | 3 | N/A | false | false |
| 29 | 28 | The Box | $156 | +300% | 2 | - | $78 | $10,104 | 9 | N/A | false | false |
| 30 | 25 | Old Dogs | $88 | -34.3% | 5 | - | $17 | $73,270 | 9 | Walt Disney Pictures | false | false |
