| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Alice in Wonderland | $743,584 | -28.5% | 92 | -1 | $8,082 | $1,969,698 | 2 | Walt Disney Pictures | false | false |
| 2 | 2 | Miss You Like Crazy | $236,366 | -61.5% | 75 | -10 | $3,151 | $2,819,040 | 3 | Star Cinema | false | false |
| 3 | - | Green Zone | $100,509 | - | 25 | - | $4,020 | $100,509 | 1 | United International Pictures | true | false |
| 4 | - | Remember Me | $73,512 | - | 45 | - | $1,633 | $73,512 | 1 | Pioneer Films | true | false |
| 5 | - | Extraordinary Measures | $68,637 | - | 40 | - | $1,715 | $68,637 | 1 | Sony Pictures Releasing | true | false |
| 6 | 3 | Cop Out | $40,571 | -70.6% | 50 | - | $811 | $210,644 | 2 | Warner Bros. | false | false |
| 7 | 4 | Percy Jackson & the Olympians: The Lightning Thief | $33,927 | -56.2% | 30 | -21 | $1,130 | $1,961,855 | 5 | 20th Century Fox International | false | false |
| 8 | 6 | The Fourth Kind | $20,666 | -52.7% | 20 | - | $1,033 | $77,415 | 2 | Viva International Pictures | false | false |
| 9 | 9 | The Wolfman | $19,268 | -4% | 15 | -19 | $1,284 | $571,692 | 5 | United International Pictures | false | false |
| 10 | 10 | Avatar | $15,842 | -14.6% | 2 | -3 | $7,921 | $5,874,867 | 13 | 20th Century Fox International | false | false |
| 11 | 5 | Up in the Air | $15,650 | -66.2% | 10 | -2 | $1,565 | $72,684 | 2 | United International Pictures | false | false |
| 12 | 8 | From Paris with Love | $12,599 | -67.2% | 25 | -5 | $503 | $181,871 | 3 | Viva International Pictures | false | false |
| 13 | 7 | The Road | $11,645 | -71.5% | 15 | -1 | $776 | $64,708 | 2 | Pioneer Films | false | false |
| 14 | 11 | Valentine's Day | $7,915 | -0.9% | 7 | -7 | $1,130 | $732,995 | 5 | Warner Bros. | false | false |
| 15 | 12 | Armored | $4,513 | -25.7% | 10 | -13 | $451 | $103,237 | 3 | Sony Pictures Releasing | false | false |
| 16 | 13 | It's Complicated | $2,493 | -48.9% | 8 | - | $311 | $78,882 | 3 | United International Pictures | false | false |
| 17 | 15 | Cloudy with a Chance of Meatballs | $1,831 | -43.6% | 1 | -1 | $1,831 | $260,373 | 7 | Sony Pictures Releasing | false | false |
| 18 | 21 | Case 39 | $1,699 | +178.5% | 4 | +3 | $424 | $66,193 | 6 | United International Pictures | false | false |
| 19 | 20 | Invictus | $1,007 | -12.4% | 3 | -2 | $335 | $57,847 | 4 | Warner Bros. | false | false |
| 20 | 16 | Crazy Heart | $985 | -54.8% | 1 | - | $985 | $4,033 | 2 | 20th Century Fox International | false | false |
| 21 | 23 | Couples Retreat | $608 | +96.8% | 2 | - | $304 | $12,982 | 4 | United International Pictures | false | false |
| 22 | 19 | Cirque du Freak: The Vampire's Assistant | $577 | -58.5% | 2 | - | $288 | $254,339 | 7 | United International Pictures | false | false |
