| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Alice in Wonderland | $68,566 | -9.3% | 4 | - | $17,141 | $155,522 | 2 | Walt Disney Pictures | false | false |
| 2 | - | Shutter Island | $59,178 | - | 10 | - | $5,917 | $59,178 | 1 | United International Pictures | true | false |
| 3 | 2 | Avatar | $46,091 | -17.8% | 7 | -1 | $6,584 | $2,113,636 | 13 | 20th Century Fox International | false | false |
| 4 | 3 | My Name Is Khan | $42,648 | -3.2% | 8 | - | $5,331 | $189,078 | 4 | 20th Century Fox International | false | false |
| 5 | - | From Paris with Love | $36,410 | - | 8 | - | $4,551 | $36,410 | 1 | N/A | true | false |
| 6 | 5 | Valentine's Day | $14,560 | -31.3% | 5 | - | $2,912 | $217,086 | 5 | Warner Bros. | false | false |
| 7 | 4 | The Wolfman | $13,977 | -56.1% | 9 | - | $1,553 | $107,565 | 3 | United International Pictures | false | false |
| 8 | 6 | The Book of Eli | $7,829 | -52.6% | 6 | -2 | $1,304 | $249,341 | 7 | - | false | false |
| 9 | - | The Children | $7,768 | - | 4 | - | $1,942 | $7,768 | 1 | - | true | false |
| 10 | 7 | Percy Jackson & the Olympians: The Lightning Thief | $7,612 | -42.3% | 8 | - | $951 | $98,228 | 5 | 20th Century Fox International | false | false |
| 11 | 9 | It's Complicated | $6,604 | -22.5% | 5 | -1 | $1,320 | $108,344 | 6 | United International Pictures | false | false |
| 12 | 11 | Sherlock Holmes | $4,675 | -30.6% | 4 | -1 | $1,168 | $392,707 | 11 | Warner Bros. | false | false |
| 13 | 12 | Up in the Air | $4,609 | -30.7% | 5 | - | $921 | $66,779 | 5 | United International Pictures | false | false |
| 14 | 8 | The Tournament | $3,347 | -66.9% | 4 | -1 | $836 | $15,493 | 2 | - | false | false |
| 15 | 10 | Stag Night | $2,860 | -64.7% | 2 | -1 | $1,430 | $26,154 | 3 | N/A | false | false |
| 16 | 14 | Alvin and the Chipmunks: The Squeakquel | $1,913 | -25.9% | 2 | -1 | $956 | $149,386 | 12 | 20th Century Fox International | false | false |
| 17 | 13 | Old Dogs | $1,900 | -46.2% | 3 | - | $633 | $123,160 | 10 | Walt Disney Pictures | false | false |
| 18 | 16 | The Princess and the Frog | $955 | +1.5% | 2 | - | $477 | $77,034 | 11 | Walt Disney Pictures | false | false |
| 19 | 17 | Did You Hear About the Morgans? | $623 | -18.3% | 1 | - | $623 | $61,652 | 7 | Sony Pictures Releasing | false | false |
| 20 | 15 | Triangle | $524 | -44.8% | 2 | -1 | $262 | $61,346 | 6 | N/A | false | false |
| 21 | 20 | 2012 | $341 | +19.2% | 1 | -1 | $341 | $1,100,015 | 18 | Sony Pictures Releasing | false | false |
| 22 | 19 | High Lane | $276 | -24% | 1 | -2 | $276 | $21,990 | 7 | N/A | false | false |
| 23 | 21 | The Box | $124 | -33.7% | 1 | - | $124 | $30,802 | 9 | N/A | false | false |
| 24 | 18 | Nine | $120 | -79.3% | 1 | -2 | $120 | $74,576 | 8 | N/A | false | false |
| 25 | 23 | The Ugly Duckling and Me! | $57 | -41.8% | 1 | - | $57 | $5,563 | 6 | N/A | false | false |
