| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Alice in Wonderland | $57,621 | - | 14 | - | $4,115 | $57,621 | 1 | Walt Disney Pictures | true | false |
| 2 | 1 | Avatar | $30,708 | -32.6% | 13 | -8 | $2,362 | $1,545,378 | 12 | 20th Century Fox International | false | false |
| 3 | - | The Blind Side | $23,273 | - | 6 | - | $3,878 | $23,273 | 1 | Warner Bros. | true | false |
| 4 | 2 | The Wolfman | $22,513 | -18.8% | 9 | - | $2,501 | $123,691 | 3 | United International Pictures | false | false |
| 5 | 7 | Cloudy with a Chance of Meatballs | $14,645 | -1.9% | 14 | -2 | $1,046 | $117,967 | 5 | Sony Pictures Releasing | false | false |
| 6 | 5 | The Lovely Bones | $13,401 | -25.3% | 7 | - | $1,914 | $36,691 | 2 | United International Pictures | false | false |
| 7 | 6 | The Spy Next Door 2010 Re-release | $13,147 | -26.7% | 5 | - | $2,629 | $34,346 | 2 | N/A | false | false |
| 8 | 3 | Edge of Darkness | $11,386 | -46.6% | 5 | - | $2,277 | $37,901 | 2 | N/A | false | false |
| 9 | 4 | Dear John | $11,094 | -43.2% | 6 | - | $1,849 | $78,446 | 3 | N/A | false | false |
| 10 | 9 | It's Complicated | $8,315 | -38.3% | 7 | - | $1,187 | $179,181 | 6 | United International Pictures | false | false |
| 11 | 8 | Valentine's Day | $7,622 | -46.2% | 8 | -2 | $952 | $148,570 | 4 | Warner Bros. | false | false |
| 12 | 11 | Up in the Air | $7,458 | -31.9% | 7 | - | $1,065 | $126,920 | 5 | United International Pictures | false | false |
| 13 | 10 | Alvin and the Chipmunks: The Squeakquel | $7,108 | -37.5% | 8 | - | $888 | $65,671 | 4 | 20th Century Fox International | false | false |
| 14 | 17 | Hachi: A Dog's Tale | $632 | -27.2% | 1 | - | $632 | $5,413 | 3 | N/A | false | false |
