| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Avatar | $3,445,083 | -21% | 398 | +7 | $8,655 | $132,296,376 | 11 | 20th Century Fox International | false | false |
| 2 | 3 | The Lovely Bones | $1,833,945 | -27.6% | 424 | +4 | $4,325 | $5,865,834 | 2 | Paramount Pictures International | false | false |
| 3 | - | The Crazies | $1,820,160 | - | 345 | - | $5,275 | $1,820,160 | 1 | Paramount Pictures International | true | false |
| 4 | 2 | The Princess and the Frog | $1,327,470 | -50.3% | 486 | -17 | $2,731 | $15,219,471 | 3 | Walt Disney Pictures | false | false |
| 5 | 5 | Percy Jackson & the Olympians: The Lightning Thief | $1,301,416 | -43.5% | 472 | +15 | $2,757 | $9,774,483 | 3 | 20th Century Fox International | false | false |
| 6 | 4 | Valentine's Day | $1,253,416 | -48.8% | 432 | -4 | $2,901 | $14,220,639 | 3 | Warner Bros. | false | false |
| 7 | - | Leap Year | $1,109,970 | - | 331 | - | $3,353 | $1,109,970 | 1 | Optimum Releasing | true | false |
| 8 | - | From Paris with Love | $1,034,827 | - | 280 | - | $3,695 | $1,034,827 | 1 | Warner Bros. | true | false |
| 9 | 12 | A Single Man | $581,449 | -0.5% | 105 | +20 | $5,537 | $2,972,641 | 3 | Icon Film Distribution | false | false |
| 10 | 9 | Invictus | $446,424 | -49.5% | 238 | -31 | $1,875 | $6,439,689 | 4 | Warner Bros. | false | false |
| 11 | 8 | Alvin and the Chipmunks: The Squeakquel | $424,705 | -54.9% | 369 | -28 | $1,150 | $35,805,642 | 10 | 20th Century Fox International | false | false |
| 12 | 10 | Astro Boy | $364,037 | -55% | 398 | -20 | $914 | $5,148,738 | 4 | Entertainment One | false | false |
| 13 | 6 | The Wolfman | $363,379 | -69.7% | 305 | -106 | $1,191 | $7,315,126 | 3 | Universal Pictures International (UPI) | false | false |
| 14 | 7 | Solomon Kane | $328,657 | -65.3% | 256 | -3 | $1,283 | $1,729,255 | 2 | Universal Pictures International (UPI) | false | false |
| 15 | 11 | My Name Is Khan | $282,472 | -59.3% | 82 | -13 | $3,444 | $3,530,549 | 3 | 20th Century Fox International | false | false |
| 16 | - | Micmacs | $278,203 | - | 85 | - | $3,272 | $278,203 | 8 | Entertainment One | false | false |
| 17 | - | Extraordinary Measures | $200,822 | - | 240 | - | $836 | $200,822 | 1 | Sony Pictures Releasing | true | false |
