| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Alice in Wonderland | $1,668,739 | - | 131 | - | $12,738 | $1,668,739 | 1 | Walt Disney Pictures | true | false |
| 2 | 2 | Edge of Darkness | $211,037 | -26.8% | 65 | +8 | $3,246 | $600,931 | 2 | Warner Bros. | false | false |
| 3 | 1 | Avatar | $136,509 | -66.4% | 86 | -26 | $1,587 | $13,150,806 | 10 | 20th Century Fox International | false | false |
| 4 | - | Bad Lieutenant: Port of Call New Orleans | $77,743 | - | 33 | - | $2,355 | $77,743 | 1 | Distribution Company | true | false |
| 5 | 5 | The Wolfman | $69,616 | -37.4% | 61 | -6 | $1,141 | $982,250 | 4 | Universal Pictures International (UPI) | false | false |
| 6 | 3 | Percy Jackson & the Olympians: The Lightning Thief | $66,586 | -53.1% | 56 | -9 | $1,189 | $615,254 | 3 | 20th Century Fox International | false | false |
| 7 | - | Couples Retreat | $58,740 | - | 23 | - | $2,553 | $58,740 | 1 | Universal Pictures International (UPI) | true | false |
| 8 | 6 | The Imaginarium of Doctor Parnassus | $44,860 | -50.5% | 27 | -3 | $1,661 | $168,749 | 2 | Sony Pictures Releasing | false | false |
| 9 | 7 | Valentine's Day | $37,243 | -49.6% | 60 | -5 | $620 | $827,939 | 4 | Warner Bros. | false | false |
| 10 | 12 | Invictus | $37,206 | -14.1% | 43 | -7 | $865 | $897,667 | 6 | Warner Bros. | false | false |
| 11 | 9 | A Serious Man | $28,925 | -46.1% | 14 | -1 | $2,066 | $98,235 | 2 | Universal Pictures International (UPI) | false | false |
| 12 | 8 | Old Dogs | $24,767 | -57.2% | 62 | -5 | $399 | $1,477,661 | 7 | Walt Disney Pictures | false | false |
| 13 | 11 | The Girl with the Dragon Tattoo | $23,971 | -47.7% | 23 | +1 | $1,042 | $202,242 | 3 | N/A | false | false |
| 14 | 10 | Birds of Paradise | $14,593 | -68.7% | 33 | -8 | $442 | $175,154 | 3 | Sony Pictures Releasing | false | false |
| 15 | 13 | Sherlock Holmes | $13,878 | -64.5% | 23 | -56 | $603 | $2,689,162 | 8 | Warner Bros. | false | false |
| 16 | 15 | Tooth Fairy | $10,206 | -57.4% | 35 | -17 | $291 | $476,139 | 5 | 20th Century Fox International | false | false |
| 17 | - | Our Beloved Month of August | $9,879 | - | 4 | - | $2,469 | $9,879 | 1 | N/A | true | false |
| 18 | 17 | Precious | $9,276 | -53.9% | 15 | -16 | $618 | $202,364 | 4 | N/A | false | false |
| 19 | 14 | The Lovely Bones | $8,436 | -77% | 18 | -39 | $468 | $196,908 | 3 | Paramount Pictures International | false | false |
| 20 | 16 | Alvin and the Chipmunks: The Squeakquel | $6,963 | -69.5% | 20 | -51 | $348 | $1,080,256 | 7 | 20th Century Fox International | false | false |
| 21 | 18 | An Education | $6,639 | -42.5% | 7 | -3 | $948 | $179,006 | 5 | Sony Pictures Releasing | false | false |
| 22 | 21 | It's Complicated | $6,286 | -31.3% | 18 | -16 | $349 | $1,306,128 | 9 | Universal Pictures International (UPI) | false | false |
| 23 | 32 | Daybreakers | $5,142 | +485.6% | 9 | +5 | $571 | $381,351 | 7 | Distribution Company | false | false |
| 24 | 27 | The Secret in Their Eyes | $5,015 | +76.8% | 16 | +1 | $313 | $9,200,619 | 30 | Distribution Company | false | false |
| 25 | 24 | The Wedding Song | $4,605 | -21.6% | 6 | - | $767 | $30,072 | 3 | Primer Plano Film Group | false | false |
| 26 | 26 | Easy Virtue | $4,300 | +26.6% | 3 | - | $1,433 | $104,560 | 8 | Sony Pictures Releasing | false | false |
| 27 | 19 | Up in the Air | $3,180 | -69.8% | 12 | -37 | $265 | $717,379 | 7 | Paramount Pictures International | false | false |
| 28 | 29 | Nora's Will | $2,613 | +14.5% | 4 | +1 | $653 | $50,747 | 6 | Primer Plano Film Group | false | false |
| 29 | 20 | The Princess and the Frog | $2,182 | -78.5% | 17 | -23 | $128 | $1,922,226 | 9 | Walt Disney Pictures | false | false |
| 30 | 23 | Zombieland | $2,010 | -69.8% | 4 | -4 | $502 | $101,762 | 6 | Sony Pictures Releasing | false | false |
| 31 | 35 | Andres Doesn't Want to Take a Nap | $1,309 | +252.8% | 5 | +3 | $261 | $13,458 | 5 | Primer Plano Film Group | false | false |
| 32 | 28 | Nine | $731 | -70.1% | 4 | -3 | $182 | $261,412 | 6 | Sony Pictures Releasing | false | false |
| 33 | 22 | Law Abiding Citizen | $626 | -91.5% | 6 | -20 | $104 | $178,554 | 4 | Alfa Films | false | false |
| 34 | 36 | The Wind Journeys | $578 | +113.3% | 3 | +1 | $192 | $4,806 | 4 | Primer Plano Film Group | false | false |
| 35 | 25 | The Young Victoria | $509 | -86.8% | 3 | -10 | $169 | $178,381 | 8 | Distribution Company | false | false |
| 36 | 31 | Astro Boy | $446 | -71.2% | 5 | -18 | $89 | $154,398 | 6 | Alfa Films | false | false |
| 37 | 33 | 2012 | $423 | -24.5% | 1 | - | $423 | $4,039,954 | 14 | Sony Pictures Releasing | false | false |
| 38 | 34 | Le code a changé | $300 | -22.7% | 2 | -1 | $150 | $135,715 | 10 | Alfa Films | false | false |
| 39 | 37 | Let it Rain | $244 | +37.9% | 1 | - | $244 | $139,633 | 13 | Alfa Films | false | false |
| 40 | 40 | Broken Embraces | $161 | +182.5% | 1 | - | $161 | $518,115 | 23 | Universal Pictures International (UPI) | false | false |
| 41 | 38 | Halloween II | $145 | -6.5% | 1 | - | $145 | $119,236 | 9 | Distribution Company | false | false |
| 42 | 41 | Departures | $93 | +200% | 1 | - | $93 | $20,037 | 8 | Alfa Films | false | false |
| 43 | 39 | Inglourious Basterds | $78 | +6.8% | 1 | - | $78 | $1,218,953 | 27 | Universal Pictures International (UPI) | false | false |
| 44 | 30 | Ninja Assassin | $67 | -97% | 1 | -11 | $67 | $129,946 | 9 | Warner Bros. | false | false |
