| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 2 | Avatar | $36,068 | -33.6% | 7 | - | $5,152 | $1,287,799 | 10 | 20th Century Fox International | false | false |
| 2 | 1 | Valentine's Day | $14,273 | -79.2% | 7 | - | $2,039 | $111,019 | 2 | - | false | false |
| 3 | 3 | The Princess and the Frog | $13,500 | -52% | 8 | - | $1,687 | $200,224 | 4 | Universal Pictures International (UPI) | false | false |
| 4 | 5 | Zero 2 | $13,062 | -36.3% | 9 | - | $1,451 | $291,212 | 5 | N/A | false | false |
| 5 | - | The Men Who Stare at Goats | $9,995 | - | 5 | - | $1,999 | $11,063 | 1 | ACME | true | false |
| 6 | - | Bad Lieutenant: Port of Call New Orleans | $9,724 | - | 4 | - | $2,431 | $9,724 | 1 | N/A | true | false |
| 7 | - | The Lovely Bones | $8,582 | - | 6 | - | $1,430 | $8,582 | 1 | Universal Pictures International (UPI) | true | false |
| 8 | 4 | The Wolfman | $8,069 | -62.5% | 7 | - | $1,152 | $43,387 | 2 | Universal Pictures International (UPI) | false | false |
| 9 | 7 | Percy Jackson & the Olympians: The Lightning Thief | $6,353 | -52.4% | 6 | - | $1,058 | $30,636 | 2 | Universal Pictures International (UPI) | false | false |
| 10 | 6 | Nasha Russia. Yaytsa sudby | $4,580 | -70.7% | 4 | -1 | $1,145 | $133,252 | 4 | ACME | false | false |
| 11 | 10 | Up in the Air | $2,362 | -67% | 5 | -1 | $472 | $59,471 | 5 | Universal Pictures International (UPI) | false | false |
| 12 | 9 | From Paris with Love | $1,908 | -74.3% | 4 | -1 | $477 | $38,803 | 3 | ACME | false | false |
| 13 | 12 | Alvin and the Chipmunks: The Squeakquel | $1,297 | -55.4% | 4 | - | $324 | $303,745 | 9 | Universal Pictures International (UPI) | false | false |
| 14 | 8 | Did You Hear About the Morgans? | $1,098 | -86.7% | 4 | -2 | $274 | $39,373 | 3 | Sony Pictures Releasing | false | false |
| 15 | 11 | Pope Joan | $785 | -74% | 1 | -1 | $785 | $15,833 | 3 | ACME | false | false |
| 16 | - | The Hurt Locker | $732 | - | 1 | - | $732 | $13,475 | 16 | ACME | false | false |
| 17 | 14 | It's Complicated | $541 | -66.1% | 2 | - | $270 | $95,447 | 6 | Universal Pictures International (UPI) | false | false |
| 18 | 15 | The World is Big and Salvation Lurks Around the Corner | $403 | -65.3% | 1 | - | $403 | $20,924 | 17 | N/A | false | false |
| 19 | - | Ninja Assassin | $191 | - | 4 | - | $47 | $30,609 | 6 | - | false | false |
| 20 | 19 | In the Loop | $142 | -23.2% | 1 | - | $142 | $4,352 | 6 | N/A | false | false |
| 21 | 16 | Sherlock Holmes | $77 | -87.5% | 6 | +2 | $12 | $236,306 | 8 | - | false | false |
| 22 | 20 | Golden Door 2010 Re-release | $10 | -89% | 1 | - | $10 | $2,027 | 7 | N/A | false | false |
| 23 | - | The Informant! | $8 | - | 1 | - | $8 | $10,394 | 14 | - | false | false |
