| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Genitori & figli:) - Agitare bene prima dell'uso | $3,802,776 | - | 471 | - | $8,073 | $3,805,130 | 1 | Filmauro | true | false |
| 2 | - | Invictus | $2,647,257 | - | 418 | - | $6,333 | $2,648,690 | 1 | Warner Bros. | true | false |
| 3 | 1 | Avatar | $2,587,970 | -31.3% | 310 | -92 | $8,348 | $84,606,810 | 7 | 20th Century Fox International | false | false |
| 4 | - | The Book of Eli | $1,800,564 | - | 331 | - | $5,439 | $1,806,278 | 1 | 01 Distribution | true | false |
| 5 | 2 | The Wolfman | $1,204,552 | -55.5% | 353 | -38 | $3,412 | $4,862,003 | 2 | United International Pictures | false | false |
| 6 | 4 | The Youngest Son | $622,720 | -52.3% | 305 | -15 | $2,041 | $2,376,786 | 2 | Medusa Distribuzione | false | false |
| 7 | 3 | Sorry If I Want to Marry You | $618,077 | -68.7% | 260 | -209 | $2,377 | $8,927,394 | 3 | Medusa Distribuzione | false | false |
| 8 | 5 | Did You Hear About the Morgans? | $573,938 | -48.1% | 225 | -7 | $2,550 | $2,074,569 | 2 | Sony Pictures Releasing | false | false |
| 9 | 8 | The Concert | $346,334 | -33.5% | 82 | -46 | $4,223 | $2,977,603 | 4 | BIM Distribuzione | false | false |
| 10 | 6 | Alvin and the Chipmunks: The Squeakquel | $318,260 | -46.2% | 159 | -70 | $2,001 | $7,963,585 | 5 | 20th Century Fox International | false | false |
| 11 | 7 | Le missionnaire | $234,139 | -57.2% | 130 | -43 | $1,801 | $980,576 | 2 | Eagle Pictures | false | false |
| 12 | 12 | Lilly the Witch: The Dragon and the Magic Book | $193,967 | -33.9% | 123 | -14 | $1,576 | $1,113,500 | 3 | Walt Disney Pictures | false | false |
| 13 | 14 | The First Beautiful Thing | $124,959 | -46.8% | 40 | -28 | $3,123 | $8,557,501 | 7 | Medusa Distribuzione | false | false |
| 14 | 9 | The Lovely Bones | $98,144 | -78.7% | 50 | -203 | $1,962 | $2,382,159 | 3 | United International Pictures | false | false |
| 15 | 13 | Up in the Air | $92,083 | -67.4% | 39 | -60 | $2,361 | $7,569,465 | 6 | United International Pictures | false | false |
| 16 | 10 | Kiss Me Again | $65,294 | -83.4% | 33 | -158 | $1,978 | $12,377,042 | 5 | Medusa Distribuzione | false | false |
| 17 | 15 | The Man Who Will Come | $46,799 | -49.6% | 24 | -14 | $1,949 | $1,374,389 | 6 | Mikado Film | false | false |
| 18 | - | Alta infedeltà | $39,069 | - | - | - | - | $39,069 | 1 | N/A | true | false |
| 19 | 16 | Lourdes | $38,720 | -52.5% | 29 | -35 | $1,335 | $430,933 | 3 | N/A | false | false |
| 20 | 20 | The Mouth of the Wolf | $38,426 | -4.8% | 17 | +10 | $2,260 | $100,603 | 2 | BIM Distribuzione | false | false |
| 21 | 21 | A Single Man | $33,331 | -15.9% | 12 | -2 | $2,777 | $1,487,085 | 7 | N/A | false | false |
| 22 | 18 | An Education | $31,488 | -53.2% | 16 | -8 | $1,968 | $452,937 | 4 | Sony Pictures Releasing | false | false |
| 23 | - | Sorority Row | $31,487 | - | 15 | - | $2,099 | $31,487 | 1 | Eagle Pictures | true | false |
| 24 | 17 | Call of the Wild | $29,674 | -57.1% | 28 | -34 | $1,059 | $113,460 | 2 | N/A | false | false |
| 25 | 19 | Soul Kitchen | $29,654 | -46.9% | 11 | -7 | $2,695 | $2,300,646 | 8 | BIM Distribuzione | false | false |
| 26 | 11 | Paranormal Activity | $23,436 | -92.6% | 19 | -183 | $1,233 | $9,153,419 | 4 | Filmauro | false | false |
| 27 | 24 | Pet Pals: Marco Polo's Code | $11,802 | -11.1% | 16 | -9 | $737 | $994,776 | 6 | 01 Distribution | false | false |
| 28 | - | Incendiary | $10,472 | - | 9 | - | $1,163 | $10,472 | 1 | N/A | true | false |
| 29 | - | Promise Me This | $10,054 | - | 9 | - | $1,117 | $29,504 | 2 | N/A | false | false |
| 30 | 22 | Me, Them and Lara | $8,983 | -63.7% | 8 | -4 | $1,122 | $21,921,613 | 8 | Warner Bros. | false | false |
| 31 | - | Alvin and the Chipmunks | $5,510 | - | 5 | - | $1,102 | $5,481,266 | 111 | 20th Century Fox International | false | false |
| 32 | 25 | Cloudy with a Chance of Meatballs | $5,068 | -49.1% | 30 | -16 | $168 | $8,253,322 | 10 | Sony Pictures Releasing | false | false |
| 33 | - | After School | $5,035 | - | 7 | - | $719 | $5,035 | 1 | N/A | true | false |
| 34 | - | The Fourth Kind | $829 | - | 1 | - | $829 | $2,426,800 | 6 | Warner Bros. | false | false |
| 35 | - | Bangkok Dangerous | $301 | - | 1 | - | $301 | $1,418,034 | 5 | Eagle Pictures | false | false |
