| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Blind Side | $2,301,205 | - | 221 | - | $10,412 | $2,616,795 | 1 | Roadshow Films | true | false |
| 2 | 2 | Shutter Island | $1,821,402 | -27.1% | 250 | - | $7,285 | $5,259,137 | 2 | Paramount Pictures International | false | false |
| 3 | 3 | Avatar | $1,531,343 | -9.2% | 229 | -25 | $6,687 | $96,633,966 | 11 | 20th Century Fox International | false | false |
| 4 | 1 | Valentine's Day | $1,356,043 | -45.8% | 366 | -7 | $3,705 | $12,811,594 | 3 | Warner Bros. | false | false |
| 5 | 4 | Percy Jackson & the Olympians: The Lightning Thief | $714,186 | -26.2% | 218 | -11 | $3,276 | $3,658,255 | 3 | 20th Century Fox International | false | false |
| 6 | 8 | The Hurt Locker | $508,335 | +84.2% | 46 | - | $11,050 | $996,950 | 2 | Roadshow Films | false | false |
| 7 | 6 | From Paris with Love | $447,539 | -8.2% | 157 | +4 | $2,850 | $1,151,789 | 2 | Hoyts Distribution | false | false |
| 8 | 5 | The Wolfman | $397,412 | -39.7% | 218 | -28 | $1,822 | $3,433,232 | 3 | Universal Pictures International (UPI) | false | false |
| 9 | - | A Single Man | $235,216 | - | 26 | - | $9,046 | $274,359 | 1 | Icon Film Distribution | true | false |
| 10 | 10 | Up in the Air | $173,653 | -33.7% | 110 | -13 | $1,578 | $6,964,413 | 7 | Paramount Pictures International | false | false |
| 11 | 16 | Bran Nue Dae | $142,901 | -8.2% | 117 | +4 | $1,221 | $6,327,972 | 7 | Roadshow Films | false | false |
| 12 | 12 | Crazy Heart | $130,397 | -34.7% | 58 | +2 | $2,248 | $415,525 | 2 | 20th Century Fox International | false | false |
| 13 | 13 | Invictus | $125,235 | -29% | 99 | -25 | $1,265 | $6,111,302 | 6 | Warner Bros. | false | false |
| 14 | 9 | It's Complicated | $115,160 | -56.3% | 103 | -47 | $1,118 | $13,876,937 | 8 | Universal Pictures International (UPI) | false | false |
| 15 | 20 | Tooth Fairy | $91,453 | -12.1% | 95 | -16 | $962 | $9,296,722 | 7 | 20th Century Fox International | false | false |
| 16 | 19 | Precious | $86,606 | -27.3% | 33 | +3 | $2,624 | $846,534 | 4 | Icon Film Distribution | false | false |
| 17 | 11 | Edge of Darkness | $84,536 | -62.3% | 133 | -62 | $635 | $3,008,179 | 4 | Icon Film Distribution | false | false |
| 18 | 17 | Daybreakers | $81,801 | -46.6% | 75 | -49 | $1,090 | $2,119,165 | 4 | Hoyts Distribution | false | false |
| 19 | 15 | My Name Is Khan | $61,036 | -61% | 34 | -3 | $1,795 | $785,538 | 3 | 20th Century Fox International | false | false |
| 20 | - | Antarctica | $57,527 | - | 1 | - | $57,527 | $4,075,362 | - | IMAX | - | false |
