| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Valentine's Day | $63,135,312 | - | 3,665 | - | $17,226 | $63,135,312 | 1 | Warner Bros. | true | false |
| 2 | - | Percy Jackson & the Olympians: The Lightning Thief | $38,661,634 | - | 3,356 | - | $11,520 | $38,661,634 | 1 | Twentieth Century Fox | true | false |
| 3 | - | The Wolfman | $35,555,065 | - | 3,222 | - | $11,035 | $35,555,065 | 1 | Universal Pictures | true | false |
| 4 | - | Avatar | $28,782,849 | - | 2,685 | - | $10,719 | $666,388,502 | 9 | Twentieth Century Fox | false | false |
| 5 | - | Dear John | $18,200,188 | - | 2,975 | - | $6,117 | $56,077,760 | 2 | Screen Gems | false | false |
| 6 | - | Tooth Fairy | $8,005,767 | - | 2,748 | - | $2,913 | $43,934,502 | 4 | Twentieth Century Fox | false | false |
| 7 | - | From Paris with Love | $6,352,780 | - | 2,722 | - | $2,333 | $17,465,570 | 2 | Lionsgate | false | false |
| 8 | - | Edge of Darkness | $5,570,476 | - | 2,615 | - | $2,130 | $37,054,157 | 3 | Warner Bros. | false | false |
| 9 | - | Crazy Heart | $4,982,062 | - | 1,005 | - | $4,957 | $17,509,037 | 9 | - | false | false |
| 10 | - | When in Rome | $4,277,925 | - | 2,125 | - | $2,013 | $26,875,654 | 3 | Walt Disney Studios Motion Pictures | false | false |
| 11 | - | The Book of Eli | $4,211,221 | - | 1,825 | - | $2,307 | $88,165,452 | 5 | Warner Bros. | false | false |
| 12 | - | The Blind Side | $2,667,208 | - | 1,175 | - | $2,269 | $245,133,549 | 13 | Warner Bros. | false | false |
| 13 | - | My Name Is Khan | $2,264,983 | - | 120 | - | $18,874 | $2,264,983 | 1 | - | true | false |
| 14 | - | Legion | $2,104,565 | - | 1,424 | - | $1,477 | $38,206,460 | 4 | Screen Gems | false | false |
| 15 | - | Up in the Air | $2,063,060 | - | 925 | - | $2,230 | $79,501,829 | 11 | Paramount Pictures | false | false |
| 16 | - | Sherlock Holmes | $1,887,397 | - | 950 | - | $1,986 | $204,350,996 | 8 | Warner Bros. | false | false |
| 17 | - | Alvin and the Chipmunks: The Squeakquel | $1,696,335 | - | 1,057 | - | $1,604 | $214,311,806 | 8 | Twentieth Century Fox | false | false |
| 18 | - | It's Complicated | $1,396,925 | - | 787 | - | $1,775 | $109,741,850 | 8 | Universal Pictures | false | false |
| 19 | - | The Princess and the Frog | $811,714 | - | 441 | - | $1,840 | $101,951,400 | 12 | Walt Disney Studios Motion Pictures | false | false |
| 20 | - | The Lovely Bones | $804,802 | - | 833 | - | $966 | $42,962,418 | 10 | DreamWorks | false | false |
| 21 | - | The Twilight Saga: New Moon | $688,386 | - | 398 | - | $1,729 | $295,061,295 | 13 | Summit Entertainment | false | false |
| 22 | - | The Last Station | $606,699 | - | 84 | - | $7,222 | $1,464,975 | 5 | Sony Pictures Classics | false | false |
| 23 | - | An Education | $583,342 | - | 333 | - | $1,751 | $10,563,708 | 19 | Sony Pictures Classics | false | false |
| 24 | - | The Spy Next Door | $576,642 | - | 403 | - | $1,430 | $23,665,971 | 5 | Lionsgate | false | false |
| 25 | - | A Single Man | $574,452 | - | 313 | - | $1,835 | $7,015,011 | 10 | The Weinstein Company | false | false |
| 26 | - | The Young Victoria | $366,862 | - | 215 | - | $1,706 | $9,490,243 | 9 | Apparition | false | false |
| 27 | - | Planet 51 | $266,576 | - | 226 | - | $1,179 | $41,583,183 | 13 | Sony Pictures Releasing | false | false |
| 28 | - | Precious | $261,563 | - | 269 | - | $972 | $46,571,484 | 15 | Lionsgate | false | false |
| 29 | - | The Imaginarium of Doctor Parnassus | $206,000 | - | 102 | - | $2,019 | $7,069,201 | 8 | Sony Pictures Classics | false | false |
| 30 | - | The White Ribbon | $195,930 | - | 45 | - | $4,354 | $1,040,703 | 7 | Sony Pictures Classics | false | false |
| 31 | - | Leap Year | $162,110 | - | 235 | - | $689 | $25,645,480 | 6 | Universal Pictures | false | false |
| 32 | 22 | Under the Sea 3D | $159,814 | -82.6% | 27 | -22 | $5,919 | $20,251,808 | 53 | Warner Bros. | false | false |
| 33 | - | 2012 | $149,288 | - | 173 | - | $862 | $166,002,736 | 14 | Sony Pictures Releasing | false | false |
| 34 | - | Invictus | $145,474 | - | 118 | - | $1,232 | $36,801,948 | 10 | Warner Bros. | false | false |
| 35 | - | Fantastic Mr. Fox | $115,775 | - | 104 | - | $1,113 | $20,679,267 | 14 | Twentieth Century Fox | false | false |
| 36 | - | Broken Embraces | $115,147 | - | 71 | - | $1,621 | $4,456,054 | 13 | Sony Pictures Classics | false | false |
| 37 | - | To Save a Life | $73,469 | - | 70 | - | $1,049 | $3,205,178 | 4 | The Samuel Goldwyn Company | false | false |
| 38 | - | Old Dogs | $57,823 | - | 85 | - | $680 | $48,436,868 | 12 | Walt Disney Studios Motion Pictures | false | false |
| 39 | - | Nine | $52,300 | - | 81 | - | $645 | $19,533,560 | 9 | The Weinstein Company | false | false |
| 40 | - | Ajami | $48,683 | - | 4 | - | $12,170 | $104,992 | 2 | Kino International | false | false |
| 41 | - | North Face | $45,686 | - | 12 | - | $3,807 | $123,037 | 3 | Music Box Films | false | false |
| 42 | - | The Messenger | $43,715 | - | 30 | - | $1,457 | $858,053 | 14 | Oscilloscope | false | false |
| 43 | - | Preacher's Kid | $36,072 | - | 27 | - | $1,336 | $362,156 | 3 | 8x Entertainment | false | false |
| 44 | - | Youth in Revolt | $32,785 | - | 35 | - | $936 | $15,150,933 | 6 | - | false | false |
| 45 | - | The Most Dangerous Man in America: Daniel Ellsberg and the Pentagon Papers | $31,420 | - | 6 | - | $5,236 | $72,590 | 3 | First Run | false | false |
| 46 | - | Saint John of Las Vegas | $28,338 | - | 14 | - | $2,024 | $72,245 | 3 | IndieVest Pictures | false | false |
| 47 | - | 3 Idiots | $28,189 | - | 12 | - | $2,349 | $6,505,658 | 8 | Reliance Big Pictures | false | false |
| 48 | - | Terribly Happy | $27,719 | - | 5 | - | $5,543 | $44,411 | 2 | Oscilloscope | false | false |
| 49 | - | Fish Tank | $25,721 | - | 11 | - | $2,338 | $227,332 | 5 | IFC Films | false | false |
| 50 | - | Creation | $25,300 | - | 9 | - | $2,811 | $174,100 | 4 | Newmarket Films | false | false |
| 51 | - | The Road | $22,769 | - | 40 | - | $569 | $7,961,078 | 12 | - | false | false |
| 52 | - | Frozen | $20,733 | - | 18 | - | $1,151 | $207,066 | 2 | Anchor Bay Films | false | false |
| 53 | - | Me and Orson Welles | $20,319 | - | 19 | - | $1,069 | $1,175,426 | 12 | Freestyle Releasing | false | false |
| 54 | - | Red Riding: The Year of Our Lord 1974 | $17,056 | - | 2 | - | $8,528 | $41,348 | 2 | IFC Films | false | false |
| 55 | - | That Evening Sun | $15,789 | - | 9 | - | $1,754 | $154,804 | 15 | Freestyle Releasing | false | false |
| 56 | - | Bad Lieutenant: Port of Call New Orleans | $14,697 | - | 16 | - | $918 | $1,676,848 | 13 | First Look International | false | false |
| 57 | - | Ran 2010 Re-release | $13,470 | - | 1 | - | $13,470 | $19,908 | 2 | Rialto Pictures | false | false |
| 58 | - | The Boondock Saints II: All Saints Day | $10,614 | - | 24 | - | $442 | $10,269,309 | 16 | Apparition | false | false |
| 59 | - | Videocracy | $10,491 | - | 1 | - | $10,491 | $10,491 | 1 | Kino International | true | false |
| 60 | - | The Private Lives of Pippa Lee | $8,346 | - | 7 | - | $1,192 | $326,144 | 12 | Screen Media Films | false | false |
| 61 | - | The Korean | $6,450 | - | 2 | - | $3,225 | $11,256 | 2 | Indican Pictures | false | false |
| 62 | - | A Town Called Panic | $6,208 | - | 2 | - | $3,104 | $94,153 | 9 | Zeitgeist Films | false | false |
| 63 | - | The Girl on the Train | $5,613 | - | 3 | - | $1,871 | $75,036 | 4 | Strand Releasing | false | false |
| 64 | - | Dolphins and Whales 3D: Tribes of the Ocean | $5,314 | - | 7 | - | $759 | $7,335,090 | - | 3D Entertainment | - | false |
| 65 | - | District 13: Ultimatum | $4,710 | - | 5 | - | $942 | $22,559 | 2 | Magnolia Pictures | false | false |
| 66 | - | Shanghai Red 2010 Re-release | $4,299 | - | 1 | - | $4,299 | $4,857 | 1 | Indican Pictures | true | false |
| 67 | - | 44 Inch Chest 2010 Re-release | $3,470 | - | 3 | - | $1,156 | $32,841 | 5 | Image Entertainment | false | false |
| 68 | - | House | $3,253 | - | 2 | - | $1,626 | $54,261 | 5 | Janus Films | false | false |
| 69 | - | 35 Shots of Rum | $3,037 | - | 2 | - | $1,518 | $159,720 | 22 | The Cinema Guild | false | false |
| 70 | - | Red Cliff | $2,154 | - | 5 | - | $430 | $603,524 | 13 | Magnolia Pictures | false | false |
| 71 | - | The Weathered Underground | $2,012 | - | 3 | - | $670 | $11,984 | 3 | Indican Pictures | false | false |
| 72 | - | Four Seasons Lodge | $1,977 | - | 1 | - | $1,977 | $51,696 | 14 | First Run | false | false |
| 73 | - | The Beaches of Agnès | $1,879 | - | 1 | - | $1,879 | $234,270 | 33 | The Cinema Guild | false | false |
| 74 | - | Seraphine | $1,850 | - | 3 | - | $616 | $875,657 | 37 | Music Box Films | false | false |
| 75 | - | Killing Kasztner | $1,603 | - | 1 | - | $1,603 | $80,684 | 17 | Sky Island Films | false | false |
| 76 | - | The Maid | $1,458 | - | 4 | - | $364 | $552,534 | 18 | Elephant Eye Films | false | false |
| 77 | - | Beeswax | $1,458 | - | 1 | - | $1,458 | $45,609 | 28 | The Cinema Guild | false | false |
| 78 | - | The Sun 2009 Re-release | $1,019 | - | 1 | - | $1,019 | $55,419 | 13 | Lorber Films | false | false |
| 79 | - | Mississippi Mermaid | $763 | - | 1 | - | $763 | $19,150 | - | The Film Desk | - | false |
| 80 | - | The Cove | $700 | - | 4 | - | $175 | $850,701 | 29 | Roadside Attractions | false | false |
| 81 | - | The Headless Woman | $640 | - | 1 | - | $640 | $97,673 | 26 | Strand Releasing | false | false |
| 82 | - | Good Hair | $580 | - | 1 | - | $580 | $4,154,052 | 19 | Roadside Attractions | false | false |
| 83 | - | The September Issue | $477 | - | 2 | - | $238 | $3,820,067 | 25 | Roadside Attractions | false | false |
| 84 | - | Yuri Gagarin Conspiracy: Fallen Idol | $456 | - | 1 | - | $456 | $13,002 | 20 | Indican Pictures | false | false |
| 85 | - | Waiting for Armageddon | $453 | - | 1 | - | $453 | $9,274 | 6 | First Run | false | false |
| 86 | - | Sweetgrass | $361 | - | 1 | - | $361 | $38,935 | 6 | The Cinema Guild | false | false |
| 87 | - | Shall We Kiss? | $273 | - | 1 | - | $273 | $535,428 | 47 | Music Box Films | false | false |
