| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Wolfman | $3,506,874 | - | 698 | - | $5,024 | $3,540,336 | 1 | Universal Pictures International (UPI) | true | false |
| 2 | - | Percy Jackson & the Olympians: The Lightning Thief | $1,688,671 | - | 700 | - | $2,412 | $1,688,671 | 1 | 20th Century Fox International | true | false |
| 3 | - | Valentine's Day | $1,111,099 | - | 350 | - | $3,174 | $1,111,099 | 1 | Warner Bros. | true | false |
| 4 | 1 | Avatar | $867,383 | -23.9% | 378 | -28 | $2,294 | $41,557,047 | 9 | 20th Century Fox International | false | false |
| 5 | 2 | Tooth Fairy | $414,863 | -31.7% | 345 | -30 | $1,202 | $7,126,829 | 5 | 20th Century Fox International | false | false |
| 6 | 4 | It's Complicated | $328,299 | -40.6% | 264 | -82 | $1,243 | $2,623,252 | 3 | Universal Pictures International (UPI) | false | false |
| 7 | 3 | The Book of Eli | $290,547 | -51.2% | 277 | -22 | $1,048 | $2,685,922 | 3 | Sony Pictures Releasing | false | false |
| 8 | - | The Hurt Locker | $141,479 | - | 66 | - | $2,143 | $141,479 | 1 | Gussi Films | true | false |
| 9 | 6 | Invictus | $127,094 | -43.1% | 129 | -41 | $985 | $1,772,235 | 4 | Warner Bros. | false | false |
| 10 | 7 | The Fourth Kind | $118,752 | -44.5% | 156 | -52 | $761 | $1,903,037 | 4 | Gussi Films | false | false |
| 11 | 5 | Up in the Air | $109,480 | -51.4% | 152 | -76 | $720 | $2,004,270 | 4 | Paramount Pictures International | false | false |
| 12 | 10 | Did You Hear About the Morgans? | $92,138 | -46.5% | 137 | -9 | $672 | $1,530,631 | 5 | Sony Pictures Releasing | false | false |
| 13 | 9 | Law Abiding Citizen | $77,830 | -59.6% | 141 | -49 | $551 | $2,101,159 | 6 | N/A | false | false |
| 14 | 8 | When in Rome | $58,517 | -71.3% | 159 | -44 | $368 | $372,892 | 2 | Walt Disney Pictures | false | false |
| 15 | 15 | Regresa | $57,850 | -34% | 88 | -40 | $657 | $1,056,361 | 4 | N/A | false | false |
| 16 | 13 | Astro Boy | $54,144 | -56.2% | 103 | -46 | $525 | $594,897 | 3 | N/A | false | false |
| 17 | 14 | Zombieland | $49,612 | -55% | 107 | -33 | $463 | $1,214,575 | 6 | Sony Pictures Releasing | false | false |
| 18 | 12 | Bad Lieutenant: Port of Call New Orleans | $38,840 | -70.7% | 85 | -17 | $456 | $258,557 | 2 | Gussi Films | false | false |
| 19 | 18 | Paranormal Activity | $29,730 | -55.2% | 55 | -53 | $540 | $5,940,056 | 8 | Gussi Films | false | false |
| 20 | 11 | Sherlock Holmes | $27,973 | -80% | 66 | -172 | $423 | $11,386,928 | 7 | Warner Bros. | false | false |
| 21 | 19 | Alvin and the Chipmunks: The Squeakquel | $22,604 | -63.5% | 55 | -91 | $410 | $10,208,074 | 8 | 20th Century Fox International | false | false |
| 22 | 22 | Mongol: The Rise of Genghis Khan | $22,374 | -51.7% | 34 | -1 | $658 | $99,828 | 2 | N/A | false | false |
| 23 | 16 | Armored | $14,904 | -81.5% | 57 | -23 | $261 | $139,467 | 2 | Sony Pictures Releasing | false | false |
| 24 | 28 | Departures | $12,185 | -27.4% | 7 | -8 | $1,740 | $97,512 | 3 | N/A | false | false |
| 25 | 25 | Pandorum | $11,998 | -59.7% | 37 | -34 | $324 | $247,859 | 5 | Gussi Films | false | false |
| 26 | 17 | Franklyn | $10,475 | -85.5% | 55 | -45 | $190 | $121,713 | 2 | N/A | false | false |
| 27 | 20 | All About Steve | $8,450 | -84.1% | 24 | -64 | $352 | $972,725 | 7 | 20th Century Fox International | false | false |
| 28 | 21 | Ninja Assassin | $8,052 | -84.8% | 36 | -53 | $223 | $362,143 | 5 | Warner Bros. | false | false |
| 29 | 27 | Everybody's Fine | $7,259 | -69.1% | 20 | -38 | $362 | $1,424,925 | 8 | Walt Disney Pictures | false | false |
| 30 | 30 | A Serious Man | $6,959 | -51.5% | 4 | -8 | $1,739 | $83,021 | 3 | Universal Pictures International (UPI) | false | false |
| 31 | 24 | Labor Pains | $6,404 | -79.1% | 20 | -48 | $320 | $652,796 | 6 | N/A | false | false |
| 32 | 26 | Mutant Chronicles | $4,814 | -83.3% | 29 | -38 | $166 | $391,669 | 6 | Videocine | false | false |
| 33 | 23 | Paintball | $4,586 | -88.5% | 27 | -53 | $169 | $69,281 | 2 | N/A | false | false |
| 34 | 32 | Julie & Julia | $3,979 | -48.2% | 11 | -7 | $361 | $583,734 | 17 | Sony Pictures Releasing | false | false |
| 35 | 29 | AAA, la película: Sin límite en el tiempo | $3,634 | -77.5% | 33 | -68 | $110 | $420,293 | 4 | Videocine | false | false |
| 36 | 34 | Motherhood | $2,657 | -55.9% | 3 | -17 | $885 | $96,433 | 3 | Gussi Films | false | false |
| 37 | - | The Baader Meinhof Complex | $2,022 | - | 2 | - | $1,011 | $2,022 | 1 | N/A | true | false |
| 38 | 39 | The Milk of Sorrow | $1,956 | -22.3% | 4 | - | $489 | $43,538 | 5 | N/A | false | false |
| 39 | 38 | Opium: Diary of a Madwoman | $1,249 | -52.8% | 1 | - | $1,249 | $51,714 | 6 | N/A | false | false |
| 40 | 33 | Fame | $924 | -87.9% | 5 | -30 | $184 | $246,763 | 5 | N/A | false | false |
| 41 | 35 | The Stepfather | $72 | -98.7% | 5 | -21 | $14 | $586,293 | 10 | Sony Pictures Releasing | false | false |
