| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Avatar | $226,639 | -28.4% | 56 | -2 | $4,047 | $9,592,074 | 10 | 20th Century Fox International | false | false |
| 2 | 2 | The Wolfman | $123,143 | -37.3% | 43 | -1 | $2,863 | $424,302 | 2 | United International Pictures | false | false |
| 3 | 3 | Percy Jackson & the Olympians: The Lightning Thief | $121,888 | -22.6% | 50 | +4 | $2,437 | $383,144 | 2 | 20th Century Fox International | false | false |
| 4 | 4 | Alvin and the Chipmunks: The Squeakquel | $98,423 | -18.1% | 48 | -6 | $2,050 | $1,124,427 | 4 | 20th Century Fox International | false | false |
| 5 | - | The Lovely Bones | $67,822 | - | 33 | - | $2,055 | $67,822 | 1 | United International Pictures | true | false |
| 6 | 5 | Valentine's Day | $49,894 | -55.7% | 30 | -2 | $1,663 | $215,837 | 2 | Warner Bros. | false | false |
| 7 | 6 | Sherlock Holmes | $42,600 | -43.9% | 29 | -17 | $1,468 | $1,183,144 | 5 | Warner Bros. | false | false |
| 8 | - | The Hurt Locker | $34,253 | - | 21 | - | $1,631 | $34,253 | 1 | N/A | true | false |
| 9 | - | Toy Story 2 2009 Re-release | $21,338 | - | 13 | - | $1,641 | $21,338 | 1 | Walt Disney Pictures | true | false |
| 10 | 7 | Invictus | $21,275 | -42.1% | 17 | -3 | $1,251 | $168,252 | 3 | Warner Bros. | false | false |
| 11 | - | Nine | $20,560 | - | 12 | - | $1,713 | $20,560 | 1 | Sony Pictures Releasing | true | false |
| 12 | - | Toy Story 2009 Re-release | $15,904 | - | 13 | - | $1,223 | $15,904 | 1 | Walt Disney Pictures | true | false |
| 13 | 9 | It's Complicated | $15,741 | -32.2% | 8 | -6 | $1,967 | $217,031 | 4 | United International Pictures | false | false |
| 14 | 8 | Up in the Air | $15,381 | -44.8% | 10 | -9 | $1,538 | $121,957 | 3 | United International Pictures | false | false |
| 15 | 10 | The Haunting in Connecticut | $6,854 | -36.3% | 8 | - | $856 | $127,772 | 6 | Transeuropa | false | false |
| 16 | 11 | Astro Boy | $5,051 | -44.4% | 8 | -6 | $631 | $178,801 | 5 | N/A | false | false |
| 17 | 16 | Two Lovers | $4,797 | +13.6% | 2 | - | $2,398 | $54,356 | 4 | N/A | false | false |
| 18 | 13 | The Imaginarium of Doctor Parnassus | $3,702 | -45.4% | 2 | -1 | $1,851 | $73,914 | 4 | Sony Pictures Releasing | false | false |
| 19 | 18 | Ninja Assassin | $2,228 | +13.9% | 5 | - | $445 | $90,734 | 4 | Warner Bros. | false | false |
| 20 | 12 | Igor | $1,608 | -81.5% | 11 | -3 | $146 | $17,414 | 2 | N/A | false | false |
| 21 | 14 | Tooth Fairy | $1,254 | -77.7% | 3 | -6 | $418 | $518,256 | 7 | 20th Century Fox International | false | false |
| 22 | 19 | Planet 51 | $1,053 | +7% | 13 | +2 | $81 | $268,262 | 13 | N/A | false | false |
| 23 | 15 | Saw VI | $762 | -84.5% | 2 | -7 | $381 | $166,660 | 5 | Walt Disney Pictures | false | false |
| 24 | 22 | Old Dogs | $506 | +48.8% | 1 | - | $506 | $357,459 | 9 | Walt Disney Pictures | false | false |
| 25 | 20 | The Princess and the Frog | $254 | -53.9% | 1 | - | $254 | $903,937 | 12 | Walt Disney Pictures | false | false |
